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ipaH7.8 from Shigella boydii Sb227

Victor ID 1551
Gene Name ipaH7.8 from Shigella boydii Sb227
Sequence Strain (Species/Organism) Shigella boydii Sb227
NCBI Gene ID 3776815
NCBI Protein GI 82524730
Locus Tag SBO_P067
Protein Accession YP_406291.1
Other Database IDs UniProtKB-ID: Q31SL9_SHIBS
UniRef100: UniRef100_Q31SL9
UniRef90: UniRef90_P18014
UniRef50: UniRef50_Q31SH3
UniParc: UPI00005E43BB
EMBL: CP000037
EMBL-CDS: ABB68939.1
RefSeq_NT: NC_007608.1
EnsemblGenome: EBESCG00000079391.
EnsemblGenome_TRS: EBESCT00000080344
EnsemblGenome_PRO: EBESCP00000077325
GenomeReviews: CP000037_GR
KEGG: sbo:SBO_P067
HOGENOM: HBG673275
OMA: HISALIV
ProtClustDB: CLSK505000
BioCyc: SBOY300268:SBO_P067-MONOMER
Taxonomy ID 300268
Plasmid No pSB4_227
Gene Starting Position 51025
Gene Ending Position 52722
Gene Strand (Orientation) -
Protein Name probably secreted by the Mxi-Spa machinery
DNA Sequence 
>gi|82524664:51025-52722 Shigella boydii Sb227 plasmid pSB4_227, complete sequence
ATTATGAATGGTGCAGTCGTGAGCCGTTTTCAGACAATCGCAGGGCCAGTACCTCGTCAGTCAACTGACG
GTAAATCTGCTGTTCAGTCTCACGCATCACCTGTGCACCGGCTTCCCTCTCCGCATCCGTATCACCGCTC
AGACCTGATGCTTTCAGCCGGTCAGCCACCCTCTGAGAGTACTCATTCTCCAGCATCTCATACTTCTGCT
CTTCTGCCTGCGCCCAGCGGTCAGCTTCCGTACGCTTCAGTACAGCATGCCATGGTCCCCAGAGGGAGAA
CCAGTCCTTAAATTCATTCTCTTCACGGCTTCTGACCATGGCTTCGGCAGTGCGGAGGTCATTTGCTGTC
ACTCCCGACACGCCATAGAAACGCATTTCCTTCACGGCAGTGGAGAGCTGAAGTTTCTCTGCGAGCATGG
TCTGGAAGGCCAGGTAGACTTCTATCTCATCCACAAAATGGAGAGTTCTGACTTTATCCCGGGCAATGTC
CTCCAGAATTTCGAGGCGGAACATTTCCCTGCCCAGGGAGAGCAGAGCGCCGGTATCATTATCGAAAAGG
CCTTCTGATGCCTGATGGACCAGGAGGGTTTTCCGGAGATTGTTCCATGTGAGCGCGACACGGTCCTCAC
AGCTCTCAGTGGCATCAGCAGCAACAGCGAAAGACTGCTGTCGAAGCTCCGCAGAGGTACTGAGTTTTTC
CAGCCATGCAGCGACCTGTTCACGGAATCCGGAGGTATTGCGTGCAGAGACGGTATCGGAAAGGCGGTCA
AGGAACGCGGAAAAGGTGTTGGCATGCTCTTCATGTTCAAAAGCATGCCATATCTGTGATACATCAGATT
GTTTGTTTTCCGGGAACCATGCTGTCACGGCATCAGCCAGGGGGCGATGGAGTGTATTCTGTTGTCCGTC
ACTCATGGAGAAGTAAATCTGCGGGCCGTGGTAGTCCGGCGAAGAGGTTAATCTTTGCAGGGATTGCAGA
ACGCGAGTCGACAATGGATTCCCTGAAATATTAATCCTGTAACTTGAATCTAATTGTGAAAAACTCTCCG
GAAGAGTGGTTATCTGATTAAAATGAAAATAATATTCCTTTTGTCTGATATTGTTTCTATCAGAAAATTG
AGGAAAAGTAACCAGATTATTGCGCTGAGCACAGAGAATTTCCAGTTTATCCGGTAAGTCGGGTAATGTT
GTCAGCCTGTTATAATAAACATGTAAAAATTTCAATTTTTCGGGAAGAGCCGGTAAATTATATAGCCTGT
TATTTTCAACAAATAATGATGTTAAATGGTTTGGCAAAACAGGAAGGTTTTCCAGTTGATTAGAACGAAC
ACTTAAAGTTGTTAATGACTCAGGAAGTTCTGGTATCACAGAAAGCCTGTTATTATCAGCATTAAGTTCT
TTGAGAAATGCAGGCAGCTTTGGCAATGATGTTAATTTATTATTTTCTACAATCAAAGCAGAAATATGCT
TTGGTAATTCGGGAAGAGACGTCAAATTTAGGTCTGATAAATTTAATACTGCTTCTTGATTCTGAAAGCA
CTGGGAGAGTCTGTTAAAAGCAATGCCTCGCTCTTCCCCGGGAGAAGAGTTCTTTTCCCATTCAGTCAGG
ATTCTCAGATAATGTTCATTACTGGTTGAGTTTGAGTTAATAGAGGGGGAGCAAGAAACTGATGAGTGTG
TATTATTTACAGAGAACA
Protein Sequence 
>gi|82524730|ref|YP_406291.1| invasion plasmid antigen [Shigella boydii Sb227] MFSVNNTHSSVSCSPSINSNSTSNEHYLRILTEWEKNSSPGEERGIAFNRLSQCFQNQEAVLNLSDLNLTSLPELPKHISALIVENNKLTSLPKLPAFLKELNADNNRLSVIPELPESLTTLSVRSNQLENLPVLPNHLTSLFVENNRLYNLPALPEKLKFLHVYYNRLTTLPDLPDKLEILCAQRNNLVTFPQFSDRNNIRQKEYYFHFNQITTLPESFSQLDSSYRINISGNPLSTRVLQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSTSAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFKDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYSQRVADRLKASGLSGDTDAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSRLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH7.8 mutants had a lower rate of exit from the endocytic vacuoles into the cytoplasm in mouse macrophages than the wild-type strain (Fernandez-Prada et al., 2000).
COG COG4886S, under S: Function unknown
References
Fernandez-Prada et al., 2000: Fernandez-Prada CM, Hoover DL, Tall BD, Hartman AB, Kopelowitz J, Venkatesan MM. Shigella flexneri IpaH(7.8) facilitates escape of virulent bacteria from the endocytic vacuoles of mouse and human macrophages. Infection and immunity. 2000; 68(6); 3608-3619. [PubMed: 10816519].