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ospB from Shigella boydii Sb227

Victor ID 1547
Gene Name ospB from Shigella boydii Sb227
Sequence Strain (Species/Organism) Shigella boydii Sb227
NCBI Gene ID 3776752
NCBI Protein GI 82524669
Locus Tag SBO_P005
Protein Accession YP_406230.1
Other Database IDs UniProtKB-ID: Q31ST0_SHIBS
UniRef100: UniRef100_Q31ST0
UniRef90: UniRef90_Q7AY55
UniRef50: UniRef50_Q7AY55
UniParc: UPI00001D8F94
EMBL: CP000037
EMBL-CDS: ABB68878.1
RefSeq_NT: NC_007608.1
EnsemblGenome: EBESCG00000079315.
EnsemblGenome_TRS: EBESCT00000080268
EnsemblGenome_PRO: EBESCP00000077249
GenomeReviews: CP000037_GR
KEGG: sbo:SBO_P005
HOGENOM: HBG210283
OMA: SITATEM
ProtClustDB: CLSK504960
BioCyc: SBOY300268:SBO_P005-MONOMER
Taxonomy ID 300268
Plasmid No pSB4_227
Gene Starting Position 2510
Gene Ending Position 3376
Gene Strand (Orientation) +
Protein Name protein secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|82524664:2510-3376 Shigella boydii Sb227 plasmid pSB4_227, complete sequence
TATGAATTTAGATGGTGTTAGACCATACTGTAGAACAGTCAATAAAAAGAATGAAAGCATATCAGATATT
GCATTTGCACATATAATAAAAAGGGTAAAAAATTCATCATGTACTCACCCAAAAGCAGCATTGGTTTTTT
TAGGAGAGAAAGGTTTTTGTGATAGCAATGATGTTCTATCTATTATGGGACAACAAATACCAAGAGTATT
TAAGAACAAGATGTTATATGATTATGTTTTTAAAAATGAAAAAAGTAAAAATGATTTTCTAAAAATGGCT
GAATCATGGCTACCACAGAGTGAACCAATAGTAATAAATAATGATGATGACGCATTGAATGCTGCTGCTT
ATTTTTCTGTAAAAAAAGCGAAAATAAAAACAGTAAACGATACTGATTTTAAAGAGTATAATAAGGTTTA
TATTCTTGGGCACGGTAGTCCTGGTTCTCATCAATTAGGCCTTGGTTCGGAACTTATTGATGTACAAACA
ATCATTTCAAGAATGAAAGACTGTGGTATTCTAAATGTGAAAGATATCCGTTTTACTTCATGCGGCTCCG
CTGATAAAGTGGCTCCTAAAAATTTTAACAATGCCCCTGCTGAAAGTCTTTCTTGTATCCTTAACTCTCT
GCCTTTTTTTAAGGAAAAAGAATCTTTGCTAGAGCAGATAAAAAAACACCTTGAAAACGATGAGTCATTG
AGTGATGGTCTAAAAATATCCGGCTATCATGGATATGGAGTTCACTATGGTCAAGAGCTTTTTCCCTACT
CACATTATCGTTCAACTTCAATTCCTGCTGATCCGGAGCATACAGTAAAAAGAAGCTCTCAGAAAAAGAC
TTTTATTATTAATAAAGAACTGGATTA
Protein Sequence 
>gi|82524669|ref|YP_406230.1| OspB [Shigella boydii Sb227] MNLDGVRPYCRTVNKKNESISDIAFAHIIKRVKNSSCTHPKAALVFLGEKGFCDSNDVLSIMGQQIPRVFKNKMLYDYVFKNEKSKNDFLKMAESWLPQSEPIVINNDDDALNAAAYFSVKKAKIKTVNDTDFKEYNKVYILGHGSPGSHQLGLGSELIDVQTIISRMKDCGILNVKDIRFTSCGSADKVAPKNFNNAPAESLSCILNSLPFFKEKESLLEQIKKHLENDESLSDGLKISGYHGYGVHYGQELFPYSHYRSTSIPADPEHTVKRSSQKKTFIINKELD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ospB mutants had reduced PMN transepithelial migration when compared to wild-type infection, PMN transepithelial migration is necessary for virulence of Shigella (Zurawski et al., 2009).
References
Zurawski et al., 2009: Zurawski DV, Mumy KL, Faherty CS, McCormick BA, Maurelli AT. Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein. Molecular microbiology. 2009; 71(2); 350-368. [PubMed: 19017275].