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virK from Shigella boydii Sb227

Victor ID 1546
Gene Name virK from Shigella boydii Sb227
Sequence Strain (Species/Organism) Shigella boydii Sb227
NCBI Gene ID 3776716
NCBI Protein GI 82524781
Locus Tag SBO_P118
Protein Accession YP_406342.1
Other Database IDs UniProtKB-ID: Q31SG8_SHIBS
UniRef100: UniRef100_Q31SG8
UniRef90: UniRef90_Q08JR6
UniRef50: UniRef50_Q9X694
UniParc: UPI00001D8FBC
EMBL: CP000037
EMBL-CDS: ABB68990.1
RefSeq_NT: NC_007608.1
EnsemblGenome: EBESCG00000079318.
EnsemblGenome_TRS: EBESCT00000080271
EnsemblGenome_PRO: EBESCP00000077252
GenomeReviews: CP000037_GR
KEGG: sbo:SBO_P118
HOGENOM: HBG468105
OMA: FHASYDE
ProtClustDB: CLSK862866
BioCyc: SBOY300268:SBO_P118-MONOMER
Taxonomy ID 300268
Plasmid No pSB4_227
Gene Starting Position 98184
Gene Ending Position 99134
Gene Strand (Orientation) +
Protein Name required for proper localization of IcsA (VirG) at the surface of bacteria
DNA Sequence 
>gi|82524664:98184-99134 Shigella boydii Sb227 plasmid pSB4_227, complete sequence
TATGTTTTCTGTAAGTAACTTATCATTTATCGGTTTCCTTAAAAGGATTGTTTTTTCCTCAGATTCACTC
CCGGGGAAGTGGGAACACAGAAAATTCCGGTTCATGTACATTTTGCGATGTGCTATAAATCCGGTTGCCA
GTATTCGATATTATTACGAACTGCGTTCCTTGCCGTGCATTGAGGATATTCTGGCAATACACCCCACGTT
GCCAGCAAGAATTCATCGCCCTTATTTGCATAAAGGGGGGCGCGCCTGGACCCGTGGACAATATATTCTT
GAGCATTATCGCTTTGTGCAAAATTTGCCAGAAAAATATTCTAAATTTTTGTTTCCACAAAAATCGGTAT
CATTAGTCCAATTCATCGGGAAAGATGGAGAGAATTTTGATATCCAGTGTTCTTCCAGTGGTTTTGACCG
GGAAGGAGAGTTGATGTTGTCATTGTTTTACAATAAAACAGTTATTACCCGGTTAACATTTTCAGTCATT
CTGACTCAAAATGGACACATTGCTTTTATTGGCGGATTACAGGGAGCCCCTAAAAATACCGGACCTGATG
TTATTCGGTGCGCAACCCGGGCCTGTTATGGGATTTTCCCAAAACGGATTATTTTTGAAGCATTTTGTGC
GTTGATGAAAGCTTGCAATATCTCTGAGTGTCTGGCAGTCAGTGAGCACAGTCATGTTTTCCGGCAATTG
AGATACTGGTATCAGAAACGCAAAACCTTTGTTGCGGTCTATAGTGATTTCTGGGAGTCTGTAGCAGGAA
AAACCTGTGGTGACTGGTACAGATTACCAACCCAGGTGATTCGAAAGCCGCTAAGCGATATAGCCAGTAA
AAAACGCTCTGAGTACCGAAAACGATACGCTTTGCTGGATTATATCCATGAAACTACTATCCGCTCTTTG
GATGCATATCCTGTACACTCAGAACATCAGGATTTAAATTA
Protein Sequence 
>gi|82524781|ref|YP_406342.1| VirK protein [Shigella boydii Sb227] MFSVSNLSFIGFLKRIVFSSDSLPGKWEHRKFRFMYILRCAINPVASIRYYYELRSLPCIEDILAIHPTLPARIHRPYLHKGGRAWTRGQYILEHYRFVQNLPEKYSKFLFPQKSVSLVQFIGKDGENFDIQCSSSGFDREGELMLSLFYNKTVITRLTFSVILTQNGHIAFIGGLQGAPKNTGPDVIRCATRACYGIFPKRIIFEAFCALMKACNISECLAVSEHSHVFRQLRYWYQKRKTFVAVYSDFWESVAGKTCGDWYRLPTQVIRKPLSDIASKKRSEYRKRYALLDYIHETTIRSLDAYPVHSEHQDLN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virK mutants have attenuated ability for intracellular spreading in host cells (Wing et al., 2005).
COG COG2990S, under S: Function unknown
References
Wing et al., 2005: Wing HJ, Goldman SR, Ally S, Goldberg MB. Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus. Infection and immunity. 2005; 73(2); 1217-1220. [PubMed: 15664968].