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ipaH9.8 from Shigella boydii Sb227

Victor ID 1545
Gene Name ipaH9.8 from Shigella boydii Sb227
Sequence Strain (Species/Organism) Shigella boydii Sb227
NCBI Gene ID 3776711
NCBI Protein GI 82524776
Locus Tag SBO_P113
Protein Accession YP_406337.1
Other Database IDs UniProtKB-ID: IPA9_SHIBS
UniRef100: UniRef100_Q31SH3
UniRef90: UniRef90_B2TT54
UniRef50: UniRef50_Q31SH3
UniParc: UPI00005E43D4
EMBL: CP000037
EMBL-CDS: ABB68985.1
RefSeq_NT: NC_007608.1
EnsemblGenome: EBESCG00000079288
EnsemblGenome_TRS: EBESCT00000080241
EnsemblGenome_PRO: EBESCP00000077222
GenomeReviews: CP000037_GR
KEGG: sbo:SBO_P113
HOGENOM: HBG673275
OMA: INNSDEL
ProtClustDB: CLSK505000
BioCyc: SBOY300268:SBO_P113-MONOMER
Taxonomy ID 300268
Plasmid No pSB4_227
Gene Starting Position 92515
Gene Ending Position 94152
Gene Strand (Orientation) +
Protein Name secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|82524664:92515-94152 Shigella boydii Sb227 plasmid pSB4_227, complete sequence
CATGTTACCGATAAATAATAACTTTTCATTGCCCCAAAATTCTTTTTATAACACTATTTCCGGTACATAT
GCTGATTACTTTTCAGCATGGGATAAATGGGAAAAACAAGCGCTCCCCGGTGAAGAGCGTGATGAGGCTG
TCTCCCGACTTAAAGAATGTCTTATCAATAATTCCGATGAACTTCGACTGGACCGTTTAAATCTGTCCTC
GCTACCTGACAACTTACCAGCTCAGATAACGCTGCTCAATGTATCATATAATCAATTAACTAACCTACCT
GAACTGCCTGTTACGCTAAAAAAATTATATTCCGCCAGCAATAAATTATCAGAATTGCCCGTGCTACCTC
CTGCGCTGGAGTCACTTCAGGTACAACACAATGAGCTGGAAAACCTGCCAGCTTTACCCGATTCGTTATT
GACTATGAATATCAGCTATAACGAAATAGTCTCCTTACCATCGCTCCCACTGGCTCTTAAAAATCTCAGA
GCGACCCGTAATTTCCTCACTGAGCTACCAGCATTTTCTGAGGGAAATAATCCCGTTGTCAGAGAGTATT
TTTTTGATAGAAATCAGATAAGTCATATCCCGGAAAGCATTCTTAATCTGAGGAATGAATGTTCAATACA
TATTAGTGATAACCCATTATCATCCCATGCTCTGCAAGCCCTGCAAAGATTAACCTCTTCGCCGGACTAC
CACGGCCCACGGATTTACTTCTCCATGAGTGACGGACAACAGAATACACTCCATCGCCCCCTGGCTGATG
CCGTGACAGCATGGTTCCCGGAAAACAAACAATCTGATGTATCACAGATATGGCATGCTTTTGAACATGA
AGAGCATGCCAACACCTTTTCCGCGTTCCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCC
GGATTCCGTGAACAGGTCGCTGCATGGCTGGAAAAACTCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTT
TCGCTGTTGCTGCTGATGCCACTGAGAGCTGTGAGGACCGTGTCGCGCTCACATGGAACAATCTCCGGAA
AACCCTCCTGGTCCATCAGGCATCAGAAGGCCTTTTCGATAATGATACCGGCGCTCTGCTCTCCCTGGGC
AGGGAAATGTTCCGCCTCGAAATTCTGGAGGACATTGCCCGGGATAAAGTCAGAACTCTCCATTTTGTGG
ACGAGATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCTCCACTGCCGTGAA
GGAAATGCGTTTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCCATGGTCAGA
AGCCGTGAAGAGAATGAATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTA
CGGAAGCTGACCGCTGGGCGCTGGCAGAAGAGCAGAAATATGAGATGCTGGAGAATGAGTACCCTCAGAG
GGTGGCTGACCGGCTGAAAGCATCAGGTCTGAGCGGTGATGCGGATGCGGAGAGGGAAGCCGGTGCACAG
GTGATGCGTGAGACTGAACAGCAGATTTACCGTCAGCTGACTGACGAGGTACTGGCCCTGCGATTGTCTG
AAAACGGCTCACAACTGCACCATTCATA
Protein Sequence 
>gi|82524776|ref|YP_406337.1| invasion plasmid antigen [Shigella boydii Sb227] MLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPLALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH9.8 deletion mutant caused more severe inflammatory responses with increased pro-inflammatory cytokine production levels than did wild-type Shigella, which resulted in a 30-fold decrease in bacterial colonization in murine lungs (Okuda et al., 2005).
COG COG4886S, under S: Function unknown
References
Okuda et al., 2005: Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, Seyedarabi A, Pickersgill R, Sasakawa C. Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses. Biochemical and biophysical research communications. 2005; 333(2); 531-539. [PubMed: 15950937].