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phoP from Shigella dysenteriae Sd197

Victor ID 1544
Gene Name phoP from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3799918
NCBI Protein GI 82777259
Locus Tag SDY_2022
Protein Accession YP_403608.1
Other Database IDs UniProtKB-ID: Q32EY8_SHIDS
UniRef100: UniRef100_Q8CXZ9
UniRef90: UniRef90_Q57QC3
UniRef50: UniRef50_Q5PMJ1
UniParc: UPI000000E0F8
EMBL: CP000034
EMBL-CDS: ABB62117.1
RefSeq_NT: NC_007606.1
EnsemblGenome: EBESCG00000080443.
EnsemblGenome_TRS: EBESCT00000081397
EnsemblGenome_PRO: EBESCP00000078377
GenomeReviews: CP000034_GR
KEGG: sdy:SDY_2022
eggNOG: COG0745
HOGENOM: HBG753323
OMA: HIEEVVA
ProtClustDB: PRK10816
BioCyc: SDYS300267:SDY_2022-MONOMER
Taxonomy ID 300267
Gene Starting Position 1830818
Gene Ending Position 1831489
Gene Strand (Orientation) +
Protein Name DNA-binding response regulator in two-component regulatory system with PhoQ
DNA Sequence 
>gi|82775382:1830818-1831489 Shigella dysenteriae Sd197, complete genome
AATGCGCGTACTGGTTGTTGAAGACAATGCGTTGTTACGTCACCACCTTAAAGTTCAGATTCAGGATGCT
GGTCATCAGGTCGATGATGCAGAAGATGCCAAAGAAGCCGATTATTATCTCAATGAACATTTACCGGATA
TTGCGATTGTCGATCTCGGATTACCAGACGAGGACGGTCTGTCACTGATTCGCCGCTGGCGTAGCAATGA
TGTTTCACTGCCGATTCTGGTATTAACCGCCCGTGAAAGCTGGCAGGACAAAGTCGAAGTATTAAGTGCC
GGTGCTGATGATTACGTGACTAAACCGTTTCATATTGAAGAGGTGATGGCGCGAATGCAGGCATTAATGC
GGCGTAATAGCGGTCTGGCTTCACAGGTCATTTCGCTACCACCGTTTCAGGTTGATCTCTCTCGCCGTGA
ATTATCTATTAATGACGAAGTGATCAAACTGACCGCGTTCGAATACACCATTATGGAAACGTTGATACGC
AATAATGGCAAAGTGGTGAGCAAAGATTCGTTAATGCTCCAACTCTATCCGGATGCGGAGCTGCGGGAAA
GCCATACCATTGATGTACTAATGGGACGTCTGCGCAAAAAAATTCAGGCACAATATCCCCAAGAAGTGAT
TACCACCGTTCGCGGCCAGGGCTATCTGTTCGAATTGCGCTG
Protein Sequence 
>gi|82777259|ref|YP_403608.1| DNA-binding transcriptional regulator PhoP [Shigella dysenteriae Sd197] MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: phoP mutants were resolved more quickly than wild type in animal models, and are more susceptible to killing by PMNs (Moss et al., 2000).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Moss et al., 2000: Moss JE, Fisher PE, Vick B, Groisman EA, Zychlinsky A. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular microbiology. 2000; 2(6); 443-452. [PubMed: 11207599].