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guaA from Shigella dysenteriae Sd197

Victor ID 1539
Gene Name guaA from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3798805
Uniprot ID Q32D55
NCBI Protein GI 82777892
Locus Tag SDY_2703
Protein Accession YP_404241.1
Other Database IDs UniProtKB-ID: GUAA_SHIDS
UniRef100: UniRef100_Q32D55
UniRef90: UniRef90_A7ZPV1
UniRef50: UniRef50_Q3JR65
UniParc: UPI00005E3547
EMBL: CP000034
EMBL-CDS: ABB62750.1
RefSeq_NT: NC_007606.1
EnsemblGenome: EBESCG00000080528
EnsemblGenome_TRS: EBESCT00000081482
EnsemblGenome_PRO: EBESCP00000078462
GenomeReviews: CP000034_GR
KEGG: sdy:SDY_2703
NMPDR: fig|216598.1.peg.1265
eggNOG: COG0519
HOGENOM: HBG391775
OMA: MKLVEPL
ProtClustDB: PRK00074
BioCyc: SDYS300267:SDY_2703-MONOMER
Taxonomy ID 300267
Gene Starting Position 2494236
Gene Ending Position 2495813
Gene Strand (Orientation) -
Protein Name bifunctional GMP synthase/glutamine amidotransferase protein
DNA Sequence 
>gi|82775382:2494236-2495813 Shigella dysenteriae Sd197, complete genome
ATCATTCCCACTCAATGGTAGCTGGCGGCTTGCCGCTGATGTCATACACCACGCGGGAAATACCGTTCAC
TTCATTGATAATGCGGTTGGAAACGCGACCGAGGAAATCGTACGGCAGATGCGCCCAGTGTGCGGTCATA
AAGTCGATGGTTTCGACAGCACGCAGAGAGACAACCCAGTCATACTTACGACCATCGCCCATTACGCCAA
CGGAACGTACTGGCAGGAAGACGGTGAACGCCTGGCTGACTTTGTCGTACAGGTCCGCTTTACGCAGTTC
TTCAATGAAGATGGCGTCAACACGGCGCAGCAGGTCACAGTACTCTTTCTTCACTTCACCCAGAACACGA
ACGCCAAGGCCTGGTCCCGGGAACGGGTGACGGTACAGCATGTCGTACGGTAGACCCAGCTCCAGACCAA
TCTTACGCACTTCGTCTTTGAACAGCTCTTTCAGCGGTTCAACCAAGCCCATCTTCATCTCTTTCGGCAG
GCCGCCCACGTTGTGGTGAGATTTGATGACGTGTGCTTTACCGGTTGCAGACGCCGCAGATTCGATAACG
TCAGGGTAGATGGTGCCCTGTGCCAGCCACTTCACGTCTTCCAGTTTCAGCGCTTCTTCATCGAATACTT
CAACGAAAACGCGACCGATGATTTTACGTTTTGCTTCCGGATCGTTTTCGCCAGCCAGCGCTGACAGGAA
GCGATCTTCTGCCGGAACGTGAACAATGTTCAGACCAAAGTGATCGCCAAACATATCCAGAACCTGCTCT
GCTTCGTTGAGACGCAGCAGGCCGTTGTCGACGAATACGCAAGTTAGGTTTTTACCGATAGCGCGGTGCA
GCAGCATTGCGGTTACGGAGGAGTCCACACCACCAGAGAGGCCGAGGATGACTTTATCGTCGCCTACCTG
CTCGCGGATGCGAGCTACAGCATCGTCGATAATTTTCGCTGGCGTCCACAGGGCTTCACACTGGCAGATA
TCACGCACAAAACGCTCCAGCATGCGCATACCCTGGCGGGTGTGAGTCACTTCCGGGTGGAACTGTACGC
CATAGAAGCGTTTTTCTTCGTTAGCCATAATGGCAAACGGGCAGCTTTCGGTGCTGGCTACGGTGATGAA
GTCGGACGGGATAGCGGTAACTTTATCGCCGTGGCTCATCCAGACATCGAGCAGCGGTTTACCGTCTGCG
GTCAGCGCATCTTCGATACCGCGAACCAGTGCGCTATCGTTTACGACTTCAACCTGCGCGTAGCCAAATT
CACGTTCGTTAGAGGCTTCAACGTGACCGCCCAACTGCATTGCCATGGTCTGCATGCCATAGCAAACGCC
GAATACCGGTACACCTGCTTCAAAGACATACTGCGGCGCACGCGGACTGTTTTCTTCTGTAGTACTTTCC
GGGCCGCCGGAAAGAATAATGCCGCTTGGATTGAAGTCACGAATTTGTGCTTCTGTCACATCCCACGCCC
ACAGTTCGCAGTAAACACCCAGCTCACGCACGCGGCGCGCAACCAGTTGAGTGTACTGAGAACCGAAGTC
CAGAATGAGGATGCGATGCTTATGAATGTTTTCCGTCA
Protein Sequence 
>gi|82777892|ref|YP_404241.1| GMP synthase [Shigella dysenteriae Sd197] MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFITVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRVDAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: guaAguaB mutants are attenuated in HeLa cells (Noriega et al., 1996).
Predicted Interacting Host Protein A1L3W5; B3KUU4; B4DR64; E9PNF5; F8VPD4; F8W720; H0Y5S6; P17812; P27708; P31327; P49915; Q6EEV6; Q6IA69; Q9NRF8
COG COG0519F, under F: Nucleotide transport and metabolism
References
Noriega et al., 1996: Noriega FR, Losonsky G, Lauderbaugh C, Liao FM, Wang JY, Levine MM. Engineered deltaguaB-A deltavirG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccine. Infection and immunity. 1996; 64(8); 3055-3061. [PubMed: 8757833].