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envZ from Shigella dysenteriae Sd197

Victor ID 1529
Gene Name envZ from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3796727
NCBI Protein GI 82778779
Locus Tag SDY_3672
Protein Accession YP_405128.1
Other Database IDs UniProtKB-ID: Q32AL8_SHIDS
UniRef100: UniRef100_P0AEJ4
UniRef90: UniRef90_P0AEJ4
UniRef50: UniRef50_P0AEJ4
UniParc: UPI0000000AFB
EMBL: CP000034
EMBL-CDS: ABB63637.1
RefSeq_NT: NC_007606.1
EnsemblGenome: EBESCG00000079573.
EnsemblGenome_TRS: EBESCT00000080526
EnsemblGenome_PRO: EBESCP00000077506
GenomeReviews: CP000034_GR
KEGG: sdy:SDY_3672
eggNOG: COG0642
HOGENOM: HBG334875
OMA: KPSYQQI
ProtClustDB: PRK09467
BioCyc: SDYS300267:SDY_3672-MONOMER
Taxonomy ID 300267
Gene Starting Position 3403518
Gene Ending Position 3404870
Gene Strand (Orientation) +
Protein Name modulates expression of ompF and ompC
DNA Sequence 
>gi|82775382:3403518-3404870 Shigella dysenteriae Sd197, complete genome
CATGAGGCGATTGCGCTTCTCGCCACGAAGTTCATTTGCCCGTACGTTATTGCTCATCGTCACCTTGCTG
TTCGCCAGCCTGGTGACAACTTATCTGGTGGTGCTGAACTTCGCGATTTTGCCGAGCCTCCAGCAGTTTA
ATAAAGTCCTCGCGTACGAAGTGCGTATGTTGATGACCGACAAACTGCAACTGGAGGACGGCACGCAGTT
GGTTGTGCCTCCCGCTTTCCGTCGGGAGATCTACCGTGAGCTGGGGATCTCTCTCTACTCCAACGAGGCT
GCCGAAGAGGCAGGTCTGCGTTGGGCGCAACACTATGAATTCTTAAGCCATCAGATGGCGCAGCAACTGG
GCGGCCCGACGGAAGTGCGCGTTGAGGTCAACAAAAGTTCGCCTGTCGTCTGGCTGAAAACCTGGCTGTC
GCCCAATATCTGGGTACGCGTGCCGCTGACCGAAATTCATCAGGGCGACTTTTCTCCGTTATTCCGCTAT
ACGCTGGCGATAATGCTGTTGGCGATAGGCGGGGCGTGGCTGTTTATTCGTATTCAGAACCGCCCGCTGG
TCGATCTCGAACATGCTGCTTTGCAGGTCGGTAAAGGGATTATTCCACCGCCGCTGCGCGAATATGGCGC
TTCGGAGGTGCGTTCAGTTACCCGCGCCTTTAACCATATGGCGGCTGGCGTCAAGCAACTGGCGGATGAC
CGTACGTTGCTCATGGCGGGGGTAAGTCATGACCTGCGCACGCCGCTGACGCGTATTCGCCTGGCGACCG
AGATGATGAGCGAGCAGGATGGCTACCTGGCAGAATCGATCAATAAAGATATCGAGGAGTGCAATGCCAT
CATTGAGCAGTTTATCGACTACCTGCGCACCGGACAGGAGATGCCGATGGAAATGGCGGATCTCAACGCA
GTACTCGGCGAGGTTATTGCTGCCGAAAGTGGCTATGAGCGGGAAATTGAAACCGCGCTTTACCCCGGCA
GCATTGAAGTGAAAATGCACCCGCTGTCGATCAAACGCGCGGTGGCGAATATGGTGGTCAACGCCGCCCG
TTACGGCAATGGCTGGATCAAAGTCAGCAGCGGGACGGAGCCGAATCGCGCCTGGTTCCAGGTGGAAGAT
GACGGTCCGGGAATTGCGCCGGAACAACGTAAGCACCTTTTCCAGCCGTTTGTTCGCGGCGACAGTGCAC
GCACCATTAGCGGCACGGGATTAGGGCTGGCGATTGTGCAGCGTATCGTGGATAACCATAACGGGATGCT
GGAGCTTGGCACCAGCGAGCGGGGCGGGCTTTCAATTCGCGCCTGGCTGCCTGTGCCGGTAACACGGGCG
CAGGGCACGACAAAAGAAGGGTA
Protein Sequence 
>gi|82778779|ref|YP_405128.1| osmolarity sensor protein [Shigella dysenteriae Sd197] MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTTKEG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: envZ insertion mutant is able to invade cells but has decreased virulence due to the inability to survive intracellularly (Bernardini et al., 1990).
COG COG0642T, under T: Signal transduction mechanisms
References
Bernardini et al., 1990: Bernardini ML, Fontaine A, Sansonetti PJ. The two-component regulatory system ompR-envZ controls the virulence of Shigella flexneri. Journal of bacteriology. 1990; 172(11); 6274-6281. [PubMed: 2121709].