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stxA

Victor ID 1526
Gene Name stxA
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3796555
NCBI Protein GI 82776676
Locus Tag SDY_1389
Protein Accession YP_403025.1
Other Database IDs UniProtKB-ID: STXA_SHIDS
UniRef100: UniRef100_Q32GM1
UniRef90: UniRef90_Q32GM1
UniRef50: UniRef50_Q32GM1
UniParc: UPI0000000DA9
EMBL: CP000034
EMBL-CDS: ABB61534.1
RefSeq_NT: NC_007606.1
EnsemblGenome: EBESCG00000081048
EnsemblGenome_TRS: EBESCT00000082002
EnsemblGenome_PRO: EBESCP00000078982
GenomeReviews: CP000034_GR
KEGG: sdy:SDY_1389
HOGENOM: HBG468772
ProtClustDB: CLSK324869
BioCyc: SDYS300267:SDY_1389-MONOMER
Taxonomy ID 300267
Gene Starting Position 1283864
Gene Ending Position 1284811
Gene Strand (Orientation) +
Protein Name Shiga toxin subunit A precursor
DNA Sequence 
>gi|82775382:1283864-1284811 Shigella dysenteriae Sd197, complete genome
TATGAAAATAATTATTTTTAGAGTGCTAACTTTTTTCTTTGTTATCTTTTCAGTTAATGTGGTTGCGAAG
GAATTTACCTTAGACTTCTCGACTGCAAAGACGTATGTAGATTCGCTGAATGTCATTCGCTCTGCAATAG
GTACTCCATTACAGACTATTTCATCAGGAGGTACGTCTTTACTGATGATTGATAGTGGCACAGGGGATAA
TTTGTTTGCAGTTGATGTCAGAGGGATAGATCCAGAGGAAGGGCGGTTTAATAATCTACGGCTTATTGTT
GAACGAAATAATTTATATGTGACAGGATTTGTTAACAGGACAAATAATGTTTTTTATCGCTTTGCTGATT
TTTCACATGTTACCTTTCCAGGTACAACAGCGGTTACATTGTCTGGTGACAGTAGCTATACCACGTTACA
GCGTGTTGCAGGGATCAGTCGTACGGGGATGCAGATAAATCGCCATTCGTTGACTACTTCTTATCTGGAT
TTAATGTCGCATAGTGGAACCTCACTGACGCAGTCTGTGGCAAGAGCGATGTTACGGTTTGTTACTGTGA
CAGCTGAAGCTTTACGTTTTCGGCAAATACAGAGGGGATTTCGTACAACACTGGATGATCTCAGTGGGCG
TTCTTATGTAATGACTGCTGAAGATGTTGATCTTACATTGAACTGGGGAAGGTTGAGTAGTGTCCTGCCT
GACTATCATGGACAAGACTCTGTTCGTGTAGGAAGAATTTCTTTTGGAAGCATTAATGCAATTCTGGGAA
GCGTGGCATTAATACTGAATTGTCATCATCATGCATCGCGAGTTGCCAGAATGGCATCTGATGAGTTTCC
TTCTATGTGTCCGGCAGATGGAAGAGTCCGTGGGATTACGCACAATAAAATATTGTGGGATTCATCCACT
CTGGGGGCAATTCTGATGCGCAGAACTATTAGCAGTTG
Protein Sequence 
>gi|82776676|ref|YP_403025.1| Shiga toxin subunit A [Shigella dysenteriae Sd197] MKIIIFRVLTFFFVIFSVNVVAKEFTLDFSTAKTYVDSLNVIRSAIGTPLQTISSGGTSLLMIDSGTGDNLFAVDVRGIDPEEGRFNNLRLIVERNNLYVTGFVNRTNNVFYRFADFSHVTFPGTTAVTLSGDSSYTTLQRVAGISRTGMQINRHSLTTSYLDLMSHSGTSLTQSVARAMLRFVTVTAEALRFRQIQRGFRTTLDDLSGRSYVMTAEDVDLTLNWGRLSSVLPDYHGQDSVRVGRISFGSINAILGSVALILNCHHHASRVARMASDEFPSMCPADGRVRGITHNKILWDSSTLGAILMRRTISS
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: STX toxin is cytotoxic for tissue culture (HeLa) cells, enterotoxic in rabbit ileal loops and lethal when injected into rabbits or mice (O'Loughlin and Robins-Browne, 2001).
References
O'Loughlin and Robins-Browne, 2001: O'Loughlin EV, Robins-Browne RM. Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells. Microbes and infection / Institut Pasteur. 2001; 3(6); 493-507. [PubMed: 11377211].