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ospD3 from Shigella dysenteriae Sd197

Victor ID 1522
Gene Name ospD3 from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776651
NCBI Protein GI 82524462
Locus Tag SDY_P056
Protein Accession YP_406057.1
Other Database IDs UniProtKB-ID: Q327D9_SHIDS
UniRef100: UniRef100_Q327D9
UniRef90: UniRef90_Q47634
UniRef50: UniRef50_Q47634
UniParc: UPI00005E39BB
EMBL: CP000035
EMBL-CDS: ABB64569.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084001.
EnsemblGenome_TRS: EBESCT00000084955
EnsemblGenome_PRO: EBESCP00000081779
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P056
NMPDR: fig|216598.1.peg.3545
eggNOG: COG0666
HOGENOM: HBG683620
OMA: CERNNAN
ProtClustDB: CLSK504968
BioCyc: SDYS300267:SDY_P056-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 49565
Gene Ending Position 51214
Gene Strand (Orientation) +
Protein Name SenA; probably secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|82524407:49565-51214 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
TATGATAAATAAAGACAACGTCTCTGTTGAGACAATCCAGTCTCTATTGCATTCAAAACAATTACCATAT
TTTTCTGACAAGAGGAGTTTTTTATTAAATCTAAATTGCCAAGTTACAGATCTCTCTGGAAGACTTATTG
TCTGTCGACATTTAGCTTCCTACTGGATAGCACAGTTTAACAAAAGTAGTGGTCACGTGGATTATCATCA
CTTTGCTTTTCCGGATGAAATTAAAAATTATGTTTCAGTGAGTGAAGAAGAAAAGGCTATTAATGTGCCT
GGCATTATTTATTTTGTTGAAAACGGTTCGTGGGGAGATATTATTTATCATATATTCAATGAAATGATTT
TTCATGCCGAAAAAAACAGAGCACTAGAAATAAGCACATCAAATCACAATATGGCATTAGGCTTGAAGAT
TAAAGAAACTAAAAATGGGGGGAGGTTTGTCATTCAGCTTTATGATCCCAACCATACAGCAACTCATTTA
CGAGCAGAGTTTAACAATTTTAACTTAGATAAAATAAAAAAACTGACTGTAGATAATTTTCTTGATGAAA
AACATCAGGAATGTTATGGTCTTATATCCGACGGAATGTCTATATTTGTGGACAGACATACTCCAACAAG
CATGTCCTCCATAATCAGATGGCCTAATAATTTACTTCACCCCAAAGTTATTTATCACGCGATGCGCATG
GGATTGACTGAGCTAATCCAAAAAGTAACAAGAGTCGTACAACTATCTGACCTTTCAGACAATACGTTAG
AATTACTTTTGGCAGCCAAAAATGACGATGGTTTGTCAGGATTGCTTTTAGCTTTACAAAATGGGCATTC
AGATACAATCTTGGCATACGGAGAACTCCTAGAAACTTCTGGACTTAACCTTGATAAAACGGTAGAACTA
CTAACTGCGGAAGGAATGGGAGGACGAATATCGGGTTTATCCCAAGCACTTCAAAATGGGCATGCAGAAA
CTATCAAAACATACGGAGGGCTTCTCAAGAAGAGAGCAATAAATATCGAATACAATAAGCTGAAAAATTT
GCTGACCGCTTATTATTACGATGAAGTACACAGACAGACACCCGGACTAATGTTTGCTCTTCAAAATGGA
CATGCAGATGCTATACGCGCATACGGTGAGCTCATTCTTAGCCTCCCTTTCCTCAACTCAGAGGATATTG
TAAATTTGCTGGCCTCAAGGAGATATGACAATGTTCCCGGACTTCTGTTAGCATTGAATAATGGACAGGC
TGATGCAATCTTAGCTTATGGTGATATCTTGAATGAGGCAAAACTTAACTTGGATAAAAAAGCAGAGCTG
TTAGCAGCGAAAGATTCTAATGGTTTATCTGGATTGTTTGTAGCCTTGCATAATGGACGTGTAGAAACAA
TTATTGCTTATGGGAAAATACTTCACACTGCAGACCTTACTCCACATCAGGCATCAAAATTACTGGCAGC
AGAAGGTCCAAATGGGGTGTCTGGATTAATTATAGCTTTTCAAAATAGGAATTTTGAGGCAATAAAAACT
TATATGGAAATAATAAAAGATGAAAATATTACACCTGAGGAAATAGCAGAGCACTTGGACAAAAAAAATG
GAAGTGATTTTCTAGAAATTATGAGTAATATAAAAAGCTG
Protein Sequence 
>gi|82524462|ref|YP_406057.1| OspD3 [Shigella dysenteriae Sd197] MINKDNVSVETIQSLLHSKQLPYFSDKRSFLLNLNCQVTDLSGRLIVCRHLASYWIAQFNKSSGHVDYHHFAFPDEIKNYVSVSEEEKAINVPGIIYFVENGSWGDIIYHIFNEMIFHAEKNRALEISTSNHNMALGLKIKETKNGGRFVIQLYDPNHTATHLRAEFNNFNLDKIKKLTVDNFLDEKHQECYGLISDGMSIFVDRHTPTSMSSIIRWPNNLLHPKVIYHAMRMGLTELIQKVTRVVQLSDLSDNTLELLLAAKNDDGLSGLLLALQNGHSDTILAYGELLETSGLNLDKTVELLTAEGMGGRISGLSQALQNGHAETIKTYGGLLKKRAINIEYNKLKNLLTAYYYDEVHRQTPGLMFALQNGHADAIRAYGELILSLPFLNSEDIVNLLASRRYDNVPGLLLALNNGQADAILAYGDILNEAKLNLDKKAELLAAKDSNGLSGLFVALHNGRVETIIAYGKILHTADLTPHQASKLLAAEGPNGVSGLIIAFQNRNFEAIKTYMEIIKDENITPEEIAEHLDKKNGSDFLEIMSNIKS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sen deletion mutant elicited lower rises in mucosal short-circuit current than the wild type, suggesting that the senA/ospD3 gene encodes an enterotoxin of Shigella (Nataro et al., 1995).
References
Nataro et al., 1995: Nataro JP, Seriwatana J, Fasano A, Maneval DR, Guers LD, Noriega F, Dubovsky F, Levine MM, Morris JG Jr. Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains. Infection and immunity. 1995; 63(12); 4721-4728. [PubMed: 7591128].