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ospC1 from Shigella dysenteriae Sd197

Victor ID 1521
Gene Name ospC1 from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776650
NCBI Protein GI 82524461
Locus Tag SDY_P055
Protein Accession YP_406056.1
Other Database IDs UniProtKB-ID: Q327E0_SHIDS
UniRef100: UniRef100_Q327E0
UniRef90: UniRef90_B2TST5
UniRef50: UniRef50_Q3YTS0
UniParc: UPI00005E39BA
EMBL: CP000035
EMBL-CDS: ABB64568.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084063.
EnsemblGenome_TRS: EBESCT00000085017
EnsemblGenome_PRO: EBESCP00000081841
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P055
NMPDR: fig|216598.1.peg.3547
eggNOG: NOG150778
HOGENOM: HBG683600
OMA: SIANQKE
ProtClustDB: CLSK504963
BioCyc: SDYS300267:SDY_P055-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 47796
Gene Ending Position 49208
Gene Strand (Orientation) +
Protein Name secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|82524407:47796-49208 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
TATGAATATATCAGAAATACTGAACTCATCAAATACCCAATGCAATATAGATTCTATGGATAACAGATTA
CATACATTGTTTCCAAAAGTGACATCAGTGCGAAACGCTGCACAACAAACTATGCCAGATGAAAAATGTT
TAAAAGATAGTGCAAATATTATTAAAGATTTCTTCAGGAAAACTATAGCAGCACAGAGTTATAGTAGAAT
GTTCTCTCAAGGCTCTAACTTTAAATCTTTAAATATAGCAATTGATGCACCATCAGACGCTAAAGCCTCA
TTTAAGGCTATTGAGCACCTTGACAGATTATCAAAGCATTATATATCTGAAATAAGGAAAAAACTTCATC
CTCTTTCTGCAAAGGAACTCAATTTGCTTTCGCTAATTATTAATTCTGATTTAATCTTCAGACATCAAAG
CAATTCTGATTTGTCTGATAAAATTTTAAACATTAAGTCATTCAATAAAATTCAGTCTGAAGGAATATGC
ACAAACCGAAACACATACGCTGATGATATAAAAAAAATAGCTAATCATGATTTTGTGTTTTTTGGCGTTG
AAATCTCTAGCCATCAGAAAAAACACCCCCTGAATACAAAACATCACACTGTTGATTTTGGTGCAAATGC
ATATATGATTGAGCATAGCTCCCCTTATGGTTATATGACATTAACTGATCATTTTGATAATGTCATCCCG
TTTGCACAATATCATGAGCATCAATCATTTTTAGATAAATTTTCAGAGGTTAATGAAGAAGTTAGTCGAT
ACGTACATGGAAGTAAAGGAATTATTGATGTACCAATATTCAATACTAAAGATATGAAGTTAGGGCTCGG
ATTATACCTGATTGACTTTATTAGAAAAAGTGAAGACCAAAGCTTCAAAGAGTTTTGCTATGAAAAAAAT
CTTTCCCCTGTGGATCTGGATAGAATCATAAACTTTGTTTTTCAGCCAGAGTACCATATACCTAGGATGG
TAAGTACAGAAAACTTCAAAAAAGTTAAGATTAGAGAAATATCCTTAGAGGAGGCTGTTACAGCATCTAA
TTACGAAGAAATTAACAAGCAGGTCACTAACAAAAAAATTGCTCTCCAGGCTCTTTTTTTTTCGATTACT
AATAAAAAAGAGGATGTCGCCTTATATATATTATCTAATTTCGAGATAACTAAACAAGATGTTATTTCCA
TAAAGCATGAGTTGTATGATATTGAGTATCTGCTTAGCGCTCATAATTCAAGCTGTAAAGTACTTGAGTA
TTTTATCAATAAGGGATTGGTTGATGTAAACACAAAGTTCAAAAAAACTAATAGTGGGGATTGTATGTTG
GATAACGCAATAAAATATGAGAATGCAGAAATGATAAAACTATTATTGAAATATGGTGCAACATCTGACA
ATAAATATATTTA
Protein Sequence 
>gi|82524461|ref|YP_406056.1| OspC1 [Shigella dysenteriae Sd197] MNISEILNSSNTQCNIDSMDNRLHTLFPKVTSVRNAAQQTMPDEKCLKDSANIIKDFFRKTIAAQSYSRMFSQGSNFKSLNIAIDAPSDAKASFKAIEHLDRLSKHYISEIRKKLHPLSAKELNLLSLIINSDLIFRHQSNSDLSDKILNIKSFNKIQSEGICTNRNTYADDIKKIANHDFVFFGVEISSHQKKHPLNTKHHTVDFGANAYMIEHSSPYGYMTLTDHFDNVIPFAQYHEHQSFLDKFSEVNEEVSRYVHGSKGIIDVPIFNTKDMKLGLGLYLIDFIRKSEDQSFKEFCYEKNLSPVDLDRIINFVFQPEYHIPRMVSTENFKKVKIREISLEEAVTASNYEEINKQVTNKKIALQALFFSITNKKEDVALYILSNFEITKQDVISIKHELYDIEYLLSAHNSSCKVLEYFINKGLVDVNTKFKKTNSGDCMLDNAIKYENAEMIKLLLKYGATSDNKYI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ospC1 mutants had reduced PMN transepithelial migration when compared to wild-type infection, PMN transepithelial migration is necessary for virulence of Shigella (Zurawski et al., 2006).
References
Zurawski et al., 2006: Zurawski DV, Mitsuhata C, Mumy KL, McCormick BA, Maurelli AT. OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulence. Infection and immunity. 2006; 74(10); 5964-5976. [PubMed: 16988276].