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ipaH7.8 from Shigella dysenteriae Sd197

Victor ID 1519
Gene Name ipaH7.8 from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776637
NCBI Protein GI 82524444
Locus Tag SDY_P038
Protein Accession YP_406039.1
Other Database IDs UniProtKB-ID: Q327F7_SHIDS
UniRef100: UniRef100_Q327F7
UniRef90: UniRef90_P18014
UniRef50: UniRef50_Q31SH3
UniParc: UPI00005E39AE
EMBL: CP000035
EMBL-CDS: ABB64551.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084011.
EnsemblGenome_TRS: EBESCT00000084965
EnsemblGenome_PRO: EBESCP00000081789
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P038
eggNOG: COG4886
HOGENOM: HBG673275
OMA: HISALIV
ProtClustDB: CLSK505000
BioCyc: SDYS300267:SDY_P038-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 34808
Gene Ending Position 36505
Gene Strand (Orientation) -
Protein Name probably secreted by the Mxi-Spa machinery
DNA Sequence 
>gi|82524407:34808-36505 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
ATTATGAATGGTGCAGTCGTGAGCCGTTTTCAGACAATCGCAGGGCCAGTACCTCGTCAGTCAACTGACG
GTAAATCTGCTGTTCAGTCTCACGCATCACCTGTGCACCGGCTTCCCTCTCCGCATCCGCATCACCGCTC
AGACCTGATGCTTTCAGCCGGTCAGCCACCCTCTGAGAGTACTCATTCTCCAGCATCTCATACTTCTGCT
CTTCTGCCTGCGCCCAGCGGTCAGCTTCCGTACGCTTCAGTACAGCATGCCATGGTCCCCAGAGGGAGAA
CCAGTCCGCAAATTCATTCTCTTCACGGCTTCTGACCGTGGCTTCGGCAGTGCGGAGGTCATTTGCTGTC
ACTCCCGACACGCCATAGAAACGCATTTCCTTCACGGCAGTGGAGAGCTGAAGTTTCTCTGCGAGCATGG
TCTGGAAGGCCAGGTAGACTTCTATCTCATCCACAAAATGGAGAGTTCTGACTTTATCCCGGGCAATGTC
CTCCAGAATTTCGAGGCGGAACATTTCCCTGCCCAGGGAGAGCAGAGCGCCGGTATCATTATCGAAAAGG
CCTTCTGATGCCTGATGGACCAGGAGGGTTTTCCGGAGATTGTTCCATGTGAGCGCGACACGGTCCTCAC
AGCTCTCAGTGGCATCAGCAGCAACAGCGAAAGACTGCTGTCGAAGCTCCGCAGAGGCACTGAGTTTTTC
CAGCCATGCAGCGACCTGTTCACGGAATCCGGAGGTATTGCGTGCAGAGACGGTATCGGAAAGGCGGTCA
AGGAACGCGGAAAAGGTGTTGGCATGCTCTTCATGTTCAAAAGCATGCCATATCTGTGATATATCAGATT
GTTTGTTTTCCGGGAACCATGCTGTCACGGCATCAGCCAGGGGGCGATGGAGTGTATTCTGTTGTCCGTC
ACTCATGGAGAAGTAAATCTGCGGGCCGTGGTAGTCCGGCGAAGAGGTTAATCTTTGCAGGGATTGCAGA
ACGCGAGTCGACAATGGATTCCCTGAAATATTAATCCTGTAACTTGAATCTAATTGTGAAAAACTCTCCG
GAAGAGTGGTTATCTGATTAAAATGAAAATAATATTCCTTCTGTCTGATATTGTTTCTATCAGAAAATTG
AGGAAAAGTAACCAGATTATTGCGCTGAGCACAGAGAATTTCCAGTTTATCCGGTAAGTCGGGTAATGTT
GTCAGCCTGTTATAATAAACATGTAAAAATTTCAATTTTTCGGGAAGAGCCGGTAAGTTATATAGCCTGT
TATTTTCAACAAATAATGATGTTAAATGGTTTGGCAAAACAGGAAGGTTTTCCAGTTGATTAGAACGAAC
ACTTAAAGTTGTTAATGACTCAGGAAGTTCTGGTATCACAGAAAGCCTGTTATTATCAGCATTAAGTTCT
TTGAGAAATGCAGGCAGCTTTGGCAATGATGTTAATTTATTATTTTCTACAATCAAAGCAGAAATATGCT
TTGGTAATTCGGGAAGAGACGTCAAATTTAGGTCTGATAAATTTAATACTGCTTCTTGATTCTGAAAGCA
CTGGGAGAGTCTGTTAAAAGCAATGCCTCGCTCTTCCCCGGGAGAAGAGTTCTTTTCCCATTCAGTCAGG
ATTCTCAGATAATGTTCATTACTGGTTAAGTTTGAGTTAATAGAGGGGGAGCAAGAAACTGATGAGTGTG
TATTATTTACAGAGAACA
Protein Sequence 
>gi|82524444|ref|YP_406039.1| invasion plasmid antigen [Shigella dysenteriae Sd197] MFSVNNTHSSVSCSPSINSNLTSNEHYLRILTEWEKNSSPGEERGIAFNRLSQCFQNQEAVLNLSDLNLTSLPELPKHISALIVENNKLTSLPKLPAFLKELNADNNRLSVIPELPESLTTLSVRSNQLENLPVLPNHLTSLFVENNRLYNLPALPEKLKFLHVYYNRLTTLPDLPDKLEILCAQRNNLVTFPQFSDRNNIRQKEYYFHFNQITTLPESFSQLDSSYRINISGNPLSTRVLQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDISQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEATVRSREENEFADWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYSQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSRLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH7.8 mutants had a lower rate of exit from the endocytic vacuoles into the cytoplasm in mouse macrophages than the wild-type strain (Fernandez-Prada et al., 2000).
COG COG4886S, under S: Function unknown
References
Fernandez-Prada et al., 2000: Fernandez-Prada CM, Hoover DL, Tall BD, Hartman AB, Kopelowitz J, Venkatesan MM. Shigella flexneri IpaH(7.8) facilitates escape of virulent bacteria from the endocytic vacuoles of mouse and human macrophages. Infection and immunity. 2000; 68(6); 3608-3619. [PubMed: 10816519].