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ospG from Shigella dysenteriae Sd197

Victor ID 1516
Gene Name ospG from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776603
NCBI Protein GI 82524507
Locus Tag SDY_P101
Protein Accession YP_406102.1
Other Database IDs UniProtKB-ID: OSPG_SHIDS
UniRef100: UniRef100_Q326Z4
UniRef90: UniRef90_Q326Z4
UniRef50: UniRef50_Q326Z4
UniParc: UPI00000BEF80
EMBL: CP000035
EMBL-CDS: ABB64614.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000083974
EnsemblGenome_TRS: EBESCT00000084928
EnsemblGenome_PRO: EBESCP00000081752
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P101
eggNOG: NOG151087
HOGENOM: HBG468694
OMA: YSATKND
ProtClustDB: CLSK688138
BioCyc: SDYS300267:SDY_P101-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 79517
Gene Ending Position 80107
Gene Strand (Orientation) +
Protein Name secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|82524407:79517-80107 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
CATGAAAATAACATCTACCATTATTCAAACACCTTTTCCATTTGAGAATAATAATTCTCATGCTGGCATA
GTAACGGAGCCCATTCTCGGTAAGTTAATAGGTCAGGGGTCGACAGCAGAAATCTTTGAAGATGTGAATG
ATTCATCTGCTTTGTATAAAAAGTATGATCTTATTGGCAACCAGTACAATGAGATTCTGGAAATGGCTTG
GCAAGAATCTGAGCTTTTTAATGCTTTTTATGGCGATGAAGCATCCGTTGTTATACAGTATGGCGGAGAT
GTGTACCTCCGAATGCTGCGCGTGCCTGGGACTCCCCTTAGTGACATTGATACAGCTGATATCCCTGATA
ATATAGAGAGCCTTTATCTACAGTTGATATGTAAATTGAATGAGTTGAGTATAATCCATTACGATCTTAA
TACAGGTAATATGCTGTATGATAAAGAAAGTGAAAGTTTATTCCCAATAGATTTTCGCAATATTTATGCT
GAATATTACGCTGCAACCAAAAAAGATAAAGAGATTATCGACCGACGATTACAAATGCGTACAAATGATT
TTTATTCGTTATTAAACAGGAAATATTTATA
Protein Sequence 
>gi|82524507|ref|YP_406102.1| OspG [Shigella dysenteriae Sd197] MKITSTIIQTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESESLFPIDFRNIYAEYYAATKKDKEIIDRRLQMRTNDFYSLLNRKYL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Upon infection of ileal loops in rabbits, the ospG mutant induced a stronger inflammatory response than the wild-type strain, indicating that OspG negatively controls the host innate response induced by S. flexneri upon invasion of the epithelium (Kim et al., 2005).
COG COG0661R, under R: General function prediction only
References
Kim et al., 2005: Kim DW, Lenzen G, Page AL, Legrain P, Sansonetti PJ, Parsot C. The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(39); 14046-14051. [PubMed: 16162672].