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ipaH9.8 from Shigella dysenteriae Sd197

Victor ID 1515
Gene Name ipaH9.8 from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776601
NCBI Protein GI 82524505
Locus Tag SDY_P099
Protein Accession YP_406100.1
Other Database IDs UniProtKB-ID: IPA9_SHIDS
UniRef100: UniRef100_Q326Z6
UniRef90: UniRef90_B2TT54
UniRef50: UniRef50_Q31SH3
UniParc: UPI0001D8973E
EMBL: CP000035
EMBL-CDS: ABB64612.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000083920
EnsemblGenome_TRS: EBESCT00000084874
EnsemblGenome_PRO: EBESCP00000081698
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P099
eggNOG: COG4886
HOGENOM: HBG673275
OMA: INNSDEL
ProtClustDB: CLSK505000
BioCyc: SDYS300267:SDY_P099-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 77121
Gene Ending Position 78788
Gene Strand (Orientation) +
Protein Name secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|82524407:77121-78788 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
TTTGTCCACCGGCTTTAACTGGATGCCCATCATGTTACCGATAAATAATAACTTTTCATTGCCCCAAAAT
TCTTTTTATAACACTATTTCCGGTACATATGCTGATTACTTTTCAGCATGGGATAAATGGGAAAAACAAG
CGCTCCCCGGTGAAGAGCGTGATGAGGCTGTCTCCCGACTTAAAGAATGTCTTATCAATAATTCCGATGA
ACTTCGACTGGACCGTTTAAATCTGTCCTCGCTACCTGACAACTTACCAGCTCAGATAACGCTGCTCAAT
GTATCATATAATCAATTAACTAACCTACCTGAACTGCCTGTTACGCTAAAAAAATTATATTCCGCCAGCA
ATAAATTATCAGAATTGCCCGTGCTACCTCCTGCGCTGGAATCACTTCAGGTACAACACAATGAGCTGGA
AAACCTGCCAGCTTTACCCGATTCGTTATTGACTATGAATATCAGCTATAACGAAATAGTCTCCTTACCA
TCGCTCCCACAGGCTCTTAAAAATCTCAGAGCGACCCGTAATTTCCTCACTGAGCTACCAGCATTTTCTG
AGGGAAATAATCCCGTTGTCAGAGAGTATTTTTTTGATAGAAATCAGATAAGTCATATCCCGGAAAGTAT
TCTTAATCTGAGGAATGAATGTTCAATACATATTAGTGATAATCCATTATCATCCCATGCTCTGCAAGCC
CTGCAAAGATTAACCTCTTCGCCGGACTACCACGGCCCACGGATTTACTTCTCCATGAGTGACGGACAAC
AGAATACACTCCATCGCCCCCTGGCTGATGCCGTGACAGCATGGTTCCCGGAAAACAAACAATCTGATGT
ATCACAGACATGGCATGCTTTTGAACATGAAGAGCATGCCAACACCTTTTCCGCATTCCTTGACCGCCTT
TCCGATACCGTCTCTGCACGCAATACCTCCGGATTCCGTGAACAGGTCGCTGCATGGCTGGAAAAACTCA
GTGCCTCTGCGGAGCTTCGACAGCAGTCTTTCGCTGTTGCTGCTGATGCCACTGAGAGCTGTGAGGACCG
TGTCGCGCTCACATGGAACAATCTCCGGAAAACCCTCCTGGTCCATCAGGCATCAGAAGGCCTTTTCGAT
AATGATACCGGCGCTCTGCTCTCCCTGGGCAGGGAAATGTTCCGCCTCGAAATTCTGGAGGACATTGCCC
GGGATAAAGTCAGAACTCTCCATTTTGTGGATGAGATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGC
AGAGAAACTTCAGCTCTCCACTGCCGTGAAGGAAATGCGTTTCTATGGCGTGTCGGGAGTGACAGCAAAT
GACCTCCGCACTGCCGAAGCCATGGTCAGAAGCCGTGAAGAGAATGAATTTACGGACTGGTTCTCCCTCT
GGGGACCATGGCATGCTGTACTGAAGCGTACGGAAGCTGACCGCTGGGCGCTGGCAGAAGAGCAGAAATA
TGAGATGCTGGAGAATGAGTACCCTCAGAGGGTGGCTGACCGGCTGAAAGCATCAGGTCTGAGCGGTGAT
GCGGATGCGGAGAGGGAAGCCGGTGCACAGGTGATGCGTGAGACTGAACAGCAGATTTACCGTCAGCTGA
CTGACGAGGTACTGGCCCTGCGATTGTCTGAAAACGGCTCACAACTGCACCATTCATA
Protein Sequence 
>gi|82524505|ref|YP_406100.1| invasion plasmid antigen [Shigella dysenteriae Sd197] MSTGFNWMPIMLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPQALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQTWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH9.8 deletion mutant caused more severe inflammatory responses with increased pro-inflammatory cytokine production levels than did wild-type Shigella, which resulted in a 30-fold decrease in bacterial colonization in murine lungs (Okuda et al., 2005).
COG COG4886S, under S: Function unknown
References
Okuda et al., 2005: Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, Seyedarabi A, Pickersgill R, Sasakawa C. Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses. Biochemical and biophysical research communications. 2005; 333(2); 531-539. [PubMed: 15950937].