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ipgB1 from Shigella dysenteriae Sd197

Victor ID 1514
Gene Name ipgB1 from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776572
NCBI Protein GI 82524574
Locus Tag SDY_P168
Protein Accession YP_406169.1
Other Database IDs UniProtKB-ID: Q326S7_SHIDS
UniRef100: UniRef100_Q326S7
UniRef90: UniRef90_P33548
UniRef50: UniRef50_P33548
UniParc: UPI00005E3A0D
EMBL: CP000035
EMBL-CDS: ABB64681.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084032.
EnsemblGenome_TRS: EBESCT00000084986
EnsemblGenome_PRO: EBESCP00000081810
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P168
HOGENOM: HBG683610
OMA: IDEMAIH
ProtClustDB: CLSK505042
BioCyc: SDYS300267:SDY_P168-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 135612
Gene Ending Position 136238
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa machinery
DNA Sequence 
>gi|82524407:135612-136238 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
TTTAATTTGTATTGCTTTGACGGTATACAGCCTTTAGAACCTCTGCGCTTATTTCTATTTGTAAAACTTT
TGTTGATTCATTAAATATTTTATCGTAGACGGAACTGGATACTAGATTTGTAAGATCCTTCATTTGTGTG
TTAAACAAATCCATGTCACTGCTATAGCGTTTTAAAATCTTTGCTCTGAGGCCAGATGAGGCAATCTCGT
TTAGTGCTGTATGACTGATAGATGTTTGTGCTGATTTTTCATCAAGTTTTATATCCGGGAATTTTTTTTC
AATAGCTGCAAATATGTTTTTTTTGTTATCTGAGGTCAAAACAACTCCATTGTGTATGGCCATTTCATCT
ATACTTCTGTTTATCATTGAAGAGACATAAGAGGTCCGCTCTTGGCTCATCCAACAAAATAGTTGATCCC
CCGAATTACTATCTTTTATTTTGTCTATGACGCTGTCCCTGATTTTATTTATATTCACCGGGCATCCAAA
ATTCTTATGAGGAAAGCGTTGTTTTAAGTTAAAAACAGATAATATTTTCTTTACAAGCTTATTGTGACTT
AACGAATTAAATGATGGGCGAGGAATCGCGAATTCAACCTGTGGAAGTATTTTGTTTAGAATTTGCA
Protein Sequence 
>gi|82524574|ref|YP_406169.1| IpgB1 [Shigella dysenteriae Sd197] MQILNKILPQVEFAIPRPSFNSLSHNKLVKKILSVFNLKQRFPHKNFGCPVNINKIRDSVIDKIKDSNSGDQLFCWMSQERTSYVSSMINRSIDEMAIHNGVVLTSDNKKNIFAAIEKKFPDIKLDEKSAQTSISHTALNEIASSGLRAKILKRYSSDMDLFNTQMKDLTNLVSSSVYDKIFNESTKVLQIEISAEVLKAVYRQSNTN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The invasiveness of the ipgB1 mutant was decreased to less than 50% of the wild-type level (100%) in a gentamicin protection or plaque forming assay (Ohya et al., 2005).
References
Ohya et al., 2005: Ohya K, Handa Y, Ogawa M, Suzuki M, Sasakawa C. IpgB1 is a novel Shigella effector protein involved in bacterial invasion of host cells. Its activity to promote membrane ruffling via Rac1 and Cdc42 activation. The Journal of biological chemistry. 2005; 280(25); 24022-24034. [PubMed: 15849186].