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ipaB from Shigella dysenteriae Sd197

Victor ID 1512
Gene Name ipaB from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776570
NCBI Protein GI 82524572
Locus Tag SDY_P166
Protein Accession YP_406167.1
Other Database IDs UniProtKB-ID: Q326S9_SHIDS
UniRef100: UniRef100_Q326S9
UniRef90: UniRef90_Q03945
UniRef50: UniRef50_P18011
UniParc: UPI00005E3A0C
EMBL: CP000035
EMBL-CDS: ABB64679.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084086.
EnsemblGenome_TRS: EBESCT00000085040
EnsemblGenome_PRO: EBESCP00000081864
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P166
NMPDR: fig|216598.1.peg.2917
eggNOG: NOG04838
HOGENOM: HBG673809
OMA: NTIQAAN
ProtClustDB: CLSK862848
BioCyc: SDYS300267:SDY_P166-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 133339
Gene Ending Position 135081
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells
DNA Sequence 
>gi|82524407:133339-135081 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
ATCAAGCAGTAGTTTGTTGCAAAATTGCTTTTGCAACATCAGTTCTATTAGCCTGAGAGTTGGACATTGA
GGCTAATAGATCTGCAATTACTTCCTGCAATTGGCCGAATTTTTCTATTGCTTCACTGATATATTTTGAC
AGTTGTTCAACTTGATATTTCGATAATGTAAGGTCTGCTAGATTTGTCGACGCGTTGTTCTGGAAAACAG
CAGAAGCGACACTTCCTCCCGCTTGTGTGGCAGAGTTAACACTTTCTCCTAATAAAACTGCTTGGTTTAA
ATGGGTGGAAATAATTTGTTTGGATATTACTTCATCACCCGCTGCACCAAGAAATTTATTTAATCTGGCA
ACAGCATTAGTGATTAAATCGTCCAGTTGAGAAGAAAAATTCTTGAGAAACTTTGGTATAAGGTCTGTGA
GGGTTTTACCTATTATTTTGCCAATATTCTCTGCAAGTTTTGCTGCTGCCTGTTTACCAACAGTGGCTAC
GAGAACGACTGCTGCAACTAGGACAAGAGCGCCTGCGATTGCCCCCAGAATAGAGCCAATCATTTTGGCT
TTTTTCGAGTCGACGCCCAAGCCTTCGAGCATTTTTGTAAATGCATCTGAAAGGAGTTTGATTAAGGGTT
CAATGACTGCTTTCATGATCGGATTCAGGGCTTGTTCCATGAAGGAATTGCCGGTCGCTGCTTGTACTAT
AGCATCCGTAACCATAAGAGCTAAACCAACAGCTGCCAGTGCTAGAGATGATCCTCCAGAAAAAGCTGCT
GCAACAACACTAACGATAGTTAAAAGTGCCCCAAGTATTTTCCCAACACAACCCATTACTCTGTTGAGTT
CTTCTGCTTTACGTACTTCAGCAGCATACTCATCAGATTTTCTCTCCATTTCAGTTTTTCTTGATTCTTG
GAGAGACTGGAATAGAGCCAGATCATTTTTTAAAGATTCTTCATTATTTTTTCCAACTAGTTGAATAAAG
GTTGCCATCAATTGAGTAACACTGGCAAGTCCGGTTAATGATTTCTGCTGGGTTGATAGCTGTTCAGCAG
ATGCTGTGTTTGAAAATGCAGAAAAAGAGTCTATTTCTTTTTCGAGTTGCATTGATTTATCTGTAAGTTT
GCTATGAATTGACAGGGTTTTCTGCTCAATCAATGTCCTGTCTTTAACTGCTGCGTCTTTTTTGATAGTG
AGTTGTATTTCTTCCCGTCTTAATTTTTTCTTTTCTGGTGAATCTGGGGCGAGTTCGGATAATCTTGTTT
GAATTTGGTTAATTTTATTTTCTAGGTCTTTTATTTTAGAATCTGCGTTTTTTAGTTTATTAATTTGCTT
TTCATAGTCTCTGGTTAGTCCTTCAGTTTCAGATAGAAGAGTATTAATTTTATCGGAGAATTCTAGGTTT
TTTTGCTGTCTTGCCTGTTGCTGAGACTTCCAAGCAGTAATTTTATTTGTTAATGCAGTTAAAGATTTTT
CACCGAGTATTTGAATAAGGTTTCCAATTAAAAGCGTTAGTTGGGAACTTGCATTTAATGACTTTGGTGC
TTTAAGTTCAGGGATTAATATATTTGAAGTTGAGTGTGCATTAGTTGTATTAATATTATTGTTAGCAGTA
AGATCAGCAATTGTAAGAGAAAATAATTTGTTAGCTGCATCATTTGCAGCCTGGATAGTATTGTCTCCAA
GCTCAGTGGAAGCCAATATTTTGGCAAGAGGCAAACCAGTGTTTGTGGTGCTTACATTATGCA
Protein Sequence 
>gi|82524572|ref|YP_406167.1| IpaB [Shigella dysenteriae Sd197] MHNVSTTNTGLPLAKILASTELGDNTIQAANDAANKLFSLTIADLTANNNINTTNAHSTSNILIPELKAPKSLNASSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLENKINQIQTRLSELAPDSPEKKKLRREEIQLTIKKDAAVKDRTLIEQKTLSIHSKLTDKSMQLEKEIDSFSAFSNTASAEQLSTQQKSLTGLASVTQLMATFIQLVGKNNEESLKNDLALFQSLQESRKTEMERKSDEYAAEVRKAEELNRVMGCVGKILGALLTIVSVVAAAFSGGSSLALAAVGLALMVTDAIVQAATGNSFMEQALNPIMKAVIEPLIKLLSDAFTKMLEGLGVDSKKAKMIGSILGAIAGALVLVAAVVLVATVGKQAAAKLAENIGKIIGKTLTDLIPKFLKNFSSQLDDLITNAVARLNKFLGAAGDEVISKQIISTHLNQAVLLGESVNSATQAGGSVASAVFQNNASTNLADLTLSKYQVEQLSKYISEAIEKFGQLQEVIADLLASMSNSQANRTDVAKAILQQTTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaB mutant is unable to infect HeLa cells (Roehrich et al., 2010).
COG COG2433S, under S: Function unknown
References
Roehrich et al., 2010: Roehrich AD, Martinez-Argudo I, Johnson S, Blocker AJ, Veenendaal AK. The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding. Infection and immunity. 2010; 78(4); 1682-1691. [PubMed: 20086081].