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ipaC from Shigella dysenteriae Sd197

Victor ID 1511
Gene Name ipaC from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776569
NCBI Protein GI 82524571
Locus Tag SDY_P165
Protein Accession YP_406166.1
Other Database IDs UniProtKB-ID: Q326T0_SHIDS
UniRef100: UniRef100_Q326T0
UniRef90: UniRef90_Q03946
UniRef50: UniRef50_P18012
UniParc: UPI00005E3A0B
EMBL: CP000035
EMBL-CDS: ABB64678.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084075.
EnsemblGenome_TRS: EBESCT00000085029
EnsemblGenome_PRO: EBESCP00000081853
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P165
NMPDR: fig|216598.1.peg.2919
eggNOG: NOG25967
HOGENOM: HBG683609
OMA: ISQASSK
ProtClustDB: CLSK862847
BioCyc: SDYS300267:SDY_P165-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 132228
Gene Ending Position 133319
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells
DNA Sequence 
>gi|82524407:132228-133319 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
ATTAAGCTCGAATGTTACCAGCAATCTGACTGGCTGTAGAACTCCTTGATTGGTTGATGTTGTCAATTAT
ATTCAATAATTTTTGTATTAATTGATTTGTCGCTTGGGATGCTTCTTTAGATACTTGGGATGCTTCCTCT
GCTTGTTTACTGCTGGCCTGACTGATTAGTTGTTCTTCTTCTTCAAGAGCAGATGCATAACGCCCTCCTG
ATGTGGATATATTACCAGCAACGGCTGATGTTTCCATTGTTGCACGGCCAATGTTTTGTTTTTGCTGAGC
AGAAAGGGTATTGAGCTCGTAAGCTCTTCTCTGGGTGTCAATTTTATCCTGCAAAGAAATATCGGGAGAA
CTAAGAGAAGTTTTATGTTCAGTTGACAGGGATATATTATCTGGTGCCAGTTTATTTTTACCTAAAATTT
TTGTGCTAGAGTTAGTTTGTGGTGAGGTGATATTTGTATCTATTTGTTTATTTAACCCTAATTTAGAACC
TGCAAGCTCTTTTTCAAGAGATTGAGCAGTGGCAAGGTTCTTTCTTAAGGCTCCTTTTTGTTCGCTAATC
CCTGAATGCGTTTTTTTGGCACCGATACCCGTTATACCTACTTGTGTGACCGCTCCAGTAATGCTTGATG
ATAGGGCTGCTAGGCCTTGCCGAACAATGTTCTCTGCAGCTGATTTTGTAGCATCGAACGCAATCAATGA
CAATTGAGAGCCCAATTTAGTTTCTGCAGTGCGGAGAGCAGAAAGTAGAACGGCTACACTAATAATTAAA
GAAACAGCATTAGAAGAAAGACTAGAAATATCCAGAGTGTTCTCTGGAGTAATTGTGTGACTCATTTCTG
AAAGATCTTTCATCTTTTTGTCAGTAAGGCGAGCAATGATTTCTGAATCATGCTGAACCTGCTCTGATAA
CTTTACAAGTTGATCATCATTTAATGTGGTTGTTAATACGGGATTTTTACCGGCATTAAGTGGAATATGC
GCTGCAATCTGCTGATAATTTTGTGATTTTTGTGTTTCGGAAGAACTTTGAGTTTGTTTTGTGGATATAT
CTGTATATAAAATCTGGGTTGGTTTTGTGTTTTGAATTTCCA
Protein Sequence 
>gi|82524571|ref|YP_406166.1| IpaC [Shigella dysenteriae Sd197] MEIQNTKPTQILYTDISTKQTQSSSETQKSQNYQQIAAHIPLNAGKNPVLTTTLNDDQLVKLSEQVQHDSEIIARLTDKKMKDLSEMSHTITPENTLDISSLSSNAVSLIISVAVLLSALRTAETKLGSQLSLIAFDATKSAAENIVRQGLAALSSSITGAVTQVGITGIGAKKTHSGISEQKGALRKNLATAQSLEKELAGSKLGLNKQIDTNITSPQTNSSTKILGKNKLAPDNISLSTEHKTSLSSPDISLQDKIDTQRRAYELNTLSAQQKQNIGRATMETSAVAGNISTSGGRYASALEEEEQLISQASSKQAEEASQVSKEASQATNQLIQKLLNIIDNINQSRSSTASQIAGNIRA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaC mutants cannot invade cultured cells or lyse red blood cells (Terry et al., 2008).
References
Terry et al., 2008: Terry CM, Picking WL, Birket SE, Flentie K, Hoffman BM, Barker JR, Picking WD. The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells. Microbial pathogenesis. 2008; 45(4); 282-289. [PubMed: 18656530].