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ipaD from Shigella dysenteriae Sd197

Victor ID 1510
Gene Name ipaD from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776568
NCBI Protein GI 82524570
Locus Tag SDY_P164
Protein Accession YP_406165.1
Other Database IDs UniProtKB-ID: Q326T1_SHIDS
UniRef100: UniRef100_Q326T1
UniRef90: UniRef90_Q03947
UniRef50: UniRef50_Q03947
UniParc: UPI00005E3A0A
EMBL: CP000035
EMBL-CDS: ABB64677.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084066.
EnsemblGenome_TRS: EBESCT00000085020
EnsemblGenome_PRO: EBESCP00000081844
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P164
NMPDR: fig|216598.1.peg.2920
eggNOG: NOG27430
HOGENOM: HBG671452
OMA: ISHRELW
ProtClustDB: CLSK2299012
BioCyc: SDYS300267:SDY_P164-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 131179
Gene Ending Position 132177
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa machinery, required for entry of bacteria into epithelial cells
DNA Sequence 
>gi|82524407:131179-132177 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
CTCAGAAATGGAGAAAAAGTTTATCTGTATCTGTACATGAACTTATTGTACTACTCAAAACCTTTACTAA
ATTATCAAAAATACTATTGGCATTACTGTATTTTTGAACTAAGGTTTGAAGATTATTTTTCATTGTTTCA
TCTTCGGCAGAGAATCCGGCATTCCATGCCTGATATTTTGCATTATCTAGCACAACCTCACCATTTCCAC
CTAGATTATTTAAGCTTTTTAACATATTGTCTATTGGGCTCATGTTTATATTGACAACATATCCCCCGTT
TTTTCTAGATACAGTGCCGATTGTTCCACCTAATTCTGTAAGCCATTTATCTGCTTGTTCCTTACTAACA
GTATTATTTGCTGGATATAGCGGTTTATCTTCATATTTTTCCTTGAGCTTTGTCAATTCGGCTTTAAGAG
AGTTGACTTGTAATTTCACGGAGTTTCCGTCGTTACCTCCGGGAGAGATCCAGCCGGCAAGACTGGAAAG
AACAGCGCTAAAATCTTGATACATTTGAGTATATGAACTAACGGCATGTTCATATACTTTCAGATACTGT
TCATTAATATTATTGATTGACTTTGCAATTTTATCCCACAGTTCTCTGTGAGATATCATTTGATATCCAT
CAAGCTCGGCTTCTTCCGGGGCTGAATGTAATAATTCTCTTGCGTCTTTATTAATTGGATATTCTTTCTT
GGAAAGAATATCCAATAGTTGAGCGGATTTGTTTACATCCATGCTAATCTGAGATGAATGTAATGCTATT
TCTTCTAGCGATGTTTTAGTCAACGTTTTTTGTGAGAGATCTTTCTTTAATGCCTGATTTGTTGTTCTGA
TATTATGAAGGGTGTCGTTGAGCATAGTAAGGGAACTTACAGGATGAGAACTGGTCGTTGTTTTTATATC
AGAATTAACTGTTTCGGTTGATGAACCGTTGGTATTGTTTGGGCTGAATGATGAGGTGGAAATACTATTA
GTCAGAGTTGTTATATTCA
Protein Sequence 
>gi|82524570|ref|YP_406165.1| IpaD [Shigella dysenteriae Sd197] MNITTLTNSISTSSFSPNNTNGSSTETVNSDIKTTTSSHPVSSLTMLNDTLHNIRTTNQALKKDLSQKTLTKTSLEEIALHSSQISMDVNKSAQLLDILSKKEYPINKDARELLHSAPEEAELDGYQMISHRELWDKIAKSINNINEQYLKVYEHAVSSYTQMYQDFSAVLSSLAGWISPGGNDGNSVKLQVNSLKAELTKLKEKYEDKPLYPANNTVSKEQADKWLTELGGTIGTVSRKNGGYVVNINMSPIDNMLKSLNNLGGNGEVVLDNAKYQAWNAGFSAEDETMKNNLQTLVQKYSNANSIFDNLVKVLSSTISSCTDTDKLFLHF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaD mutants are completely unable to invade cultured cells or lyse RBCs (Picking et al., 2005).
References
Picking et al., 2005: Picking WL, Nishioka H, Hearn PD, Baxter MA, Harrington AT, Blocker A, Picking WD. IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes. Infection and immunity. 2005; 73(3); 1432-1440. [PubMed: 15731041].