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ipaA from Shigella dysenteriae Sd197

Victor ID 1509
Gene Name ipaA from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776567
NCBI Protein GI 82524569
Locus Tag SDY_P163
Protein Accession YP_406164.1
Other Database IDs UniProtKB-ID: Q326T2_SHIDS
UniRef100: UniRef100_Q326T2
UniRef90: UniRef90_P18010
UniRef50: UniRef50_P18010
UniParc: UPI00005E3A09
EMBL: CP000035
EMBL-CDS: ABB64676.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084014.
EnsemblGenome_TRS: EBESCT00000084968
EnsemblGenome_PRO: EBESCP00000081792
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P163
NMPDR: fig|216598.1.peg.2921
eggNOG: NOG25973
HOGENOM: HBG683608
OMA: HENPEND
ProtClustDB: CLSK505037
BioCyc: SDYS300267:SDY_P163-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 129269
Gene Ending Position 131170
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells
DNA Sequence 
>gi|82524407:129269-131170 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
TTTAATCCTTATTGATATTCTTTAATACTTTTGATAGGGAAGTGGTTACATCTTTTGCTGCTTTATATAT
ATTATTGTTTTCAGCTGTAATATCATTGTTATTTTTTAAATTAGATATATCTTCTGTAAGTAATTCTGCC
GAGGTATCGTCAATTTTTGACAATACCTTGCTGAGGGCGCTAGATACTTCTTTTGCCTTTTCATAGATCG
CATGATTTTTATCAATTGTATCTGCGTTGGTTTCTGTTACGTAGTTTAGTGTATTTGCATCTGTAATTTT
TAATTTGTTGTTTATTCTGTGTTCTGTTGTGGATTTTGTAATGTCCTTTGATTTTTCCTGTAACTCTCGT
TCTTGTGTTCCTGATTTAGTTCCAATGAGAGATATAAGATTACTTAGGGAGTTTGTTACTTTTTTTGAAG
CTTCAAATATCGTTTCCCGTGTTAAATATGGGTCTCCATTTCTTGATAAAAAATCAGTCTGAAGTACTTT
TGAGTCAGTGTTTGAGTTGAATTTACTGATTTGCGAAGTTACTCTATGAGAAAAAGAAGCGCTACTTTTA
GTTGTATCTGATGAGTTATCATTACTGTTTGTCACTCCTTCCGGGCGGAGAGGGGTGGTGGTTGAAGAGT
TCTGTATGTTCAGAGGCCTGTGTCCCCGAGAAAGAGAGTTATTTGCAGATCTTTCTTGACTACTCGTAGT
TAACAGGTCTGAATCTATTCCATCCGAATTATCTGGAGTATGGTTGAAAACCTTTTCTAAAGCTGAATTA
TTTGCAAATGTCTGGACAGTATCTGATATAGAGTGTGGTAGAACGGAAGTTACTTTTTGGACTAGTGCTC
TTTGTGGGTTGAGTAATGAGTTTGCGTTACGAGGTAATAGATCGTTTGTCTGAGAAGTAGGAGACTGTGC
ATCATTTTCTGGGTTCTCGTGATAGCTATTGTCATATACTCTGTTGTCAAAAACTCTATTATCGTAAGTT
CTATTATCATTATTTATATGATAGTGAATTACAGGTTGGGATGTTTTCTCATTGGCCCCGGGGGTTGGTC
CGCCATCTGGCATATCTTTGGGAGGGGTGGGGAGTCCATCTTGGATAGGATGCGAATCTTTTATATCTTC
TAAAATATTATTAAGGACTTTTCTCAACAGCTCAGGGAACACGGCTACCGTATTTAAGTCTCTTGACAGT
TTGCCTATACCAAATCCATTACTATCAATAGTATTTTTACGTTGATTGCGCAAACTATCAAAGGCAAGTT
TTGCCTGTGCGTCAACTAAATCATCTAGTTTGAGTGATGAAACAGTTTCATTACTTAGCTTTAATTCAGC
CAGAATATTATTCTTGATAAATGATGATACTTCAGTATTGAGGAGTTTTTGTCCCAATGATAAAGCTTCA
CCAGATGTGTGTTGTTGTGCTAATAGTGCAAGTCTGTGCTCAATGTTTTGTCGTAATTGATGGAGTTTCT
TATTCTTTGCCGACCATGGTCCAAAGGCAGAATCTTGGGATAATTTATCTTTTATAATTAGTTCCGAATA
CTGTGCGACAATTTTTTGAAGTCCCTTTTCGTTTTCAAAATTCAGACCATTTTGATGTACTAAGGAGTAC
AAAACATTTGAAAATTCGATAATCTCGCTTTTGGCATACGCATTCATTGAGTTGGAATAAATGCTTCTTA
ACACATCTTCTTTCCCTGAGGAAGAAAATAAAAAGTCAAGACATTTCTGATTAAAAGACGTTGCAAAGCT
TTCTTTTTCAGACACTGATGATGGTGTTTTTAGAGAAGTTTGCGAACTATGGATATCGGATATTTTGCTT
TTTAACTCGCTGTATTCTGTTGATGATGGTGAAGTTGCCTTATATAAGAACGTTGTCGCTTGAGTATTAT
TTACATTATGCA
Protein Sequence 
>gi|82524569|ref|YP_406164.1| IpaA [Shigella dysenteriae Sd197] MHNVNNTQATTFLYKATSPSSTEYSELKSKISDIHSSQTSLKTPSSVSEKESFATSFNQKCLDFLFSSSGKEDVLRSIYSNSMNAYAKSEIIEFSNVLYSLVHQNGLNFENEKGLQKIVAQYSELIIKDKLSQDSAFGPWSAKNKKLHQLRQNIEHRLALLAQQHTSGEALSLGQKLLNTEVSSFIKNNILAELKLSNETVSSLKLDDLVDAQAKLAFDSLRNQRKNTIDSNGFGIGKLSRDLNTVAVFPELLRKVLNNILEDIKDSHPIQDGLPTPPKDMPDGGPTPGANEKTSQPVIHYHINNDNRTYDNRVFDNRVYDNSYHENPENDAQSPTSQTNDLLPRNANSLLNPQRALVQKVTSVLPHSISDTVQTFANNSALEKVFNHTPDNSDGIDSDLLTTSSQERSANNSLSRGHRPLNIQNSSTTTPLRPEGVTNSNDNSSDTTKSSASFSHRVTSQISKFNSNTDSKVLQTDFLSRNGDPYLTRETIFEASKKVTNSLSNLISLIGTKSGTQERELQEKSKDITKSTTEHRINNKLKITDANTLNYVTETNADTIDKNHAIYEKAKEVSSALSKVLSKIDDTSAELLTEDISNLKNNNDITAENNNIYKAAKDVTTSLSKVLKNINKD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaA mutants are attenuated in invasion of HeLa cells (Tran et al., 1997).
References
Tran et al., 1997: Tran Van Nhieu G, Ben-Ze'ev A, Sansonetti PJ. Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin. The EMBO journal. 1997; 16(10); 2717-2729. [PubMed: 9184218].