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ospB from Shigella dysenteriae Sd197

Victor ID 1507
Gene Name ospB from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776546
NCBI Protein GI 82524410
Locus Tag SDY_P003
Protein Accession YP_406005.1
Other Database IDs UniProtKB-ID: Q327J1_SHIDS
UniRef100: UniRef100_Q327J1
UniRef90: UniRef90_Q7AY55
UniRef50: UniRef50_Q7AY55
UniParc: UPI00005E3995
EMBL: CP000035
EMBL-CDS: ABB64517.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084061.
EnsemblGenome_TRS: EBESCT00000085015
EnsemblGenome_PRO: EBESCP00000081839
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P003
NMPDR: fig|216598.1.peg.3932
eggNOG: NOG149380
HOGENOM: HBG210283
OMA: SITATEM
ProtClustDB: CLSK504960
BioCyc: SDYS300267:SDY_P003-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 1232
Gene Ending Position 1915
Gene Strand (Orientation) +
Protein Name protein secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|82524407:1232-1915 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
TATGGGACAACAAATACCAAGAGTATTTAAGAACAAGATGTTATATGATTATGTTTTTAAAAATGAAAAA
AGTAAAAATGATTTTCTAAAAATGGCTGAATCATGGCTACCACAGAGTGAACCAGTAGTAATAAATAATG
ATGATGACGCATTGAATGCTGCTGCTTATTTTTCTGTAAAAAAAGCGAAAATAAAAACAGTAAACGATAC
TGATTTTAAAGAGTATAATAAGGTTTATATTCTTGGGCACGGTAGTCCTGGTTCTCATCAATTAGGCCTT
GGTTCGGAGCTTATTGATGTACAAACAATCATTTCAAGAATGAAAGACTGTGGTATTCTAAATGTGAAAG
ATATCCGTTTTACTTCATGCGGCTCCGCTGATAAAGTGGCTCCTAAAGATTTTAACAATGCCCCTGCTGA
AAGTCTTTCTTGTATCCTTAACTCTCTGCCTTTTTTTAAGGAAAAAGAATCTTTGCTAGAGCAGATAAAA
AAACACCTTGAAAACGATGAGTCATTGAGTGATGGTCTAAAAATATCCGGCTATCATGGATATGGAGTCC
ACTATGGTCAAGAGCTTTTTCCCTACTCACATTATCGTTCAACTTCAATTCCTGCTGATCCGGAGCATAC
AGTAAAAAGAAGCTCTCAGAAAAAGACTTTTATTATTAATAAAGAACTGGATTA
Protein Sequence 
>gi|82524410|ref|YP_406005.1| OspB [Shigella dysenteriae Sd197] MGQQIPRVFKNKMLYDYVFKNEKSKNDFLKMAESWLPQSEPVVINNDDDALNAAAYFSVKKAKIKTVNDTDFKEYNKVYILGHGSPGSHQLGLGSELIDVQTIISRMKDCGILNVKDIRFTSCGSADKVAPKDFNNAPAESLSCILNSLPFFKEKESLLEQIKKHLENDESLSDGLKISGYHGYGVHYGQELFPYSHYRSTSIPADPEHTVKRSSQKKTFIINKELD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ospB mutants had reduced PMN transepithelial migration when compared to wild-type infection, PMN transepithelial migration is necessary for virulence of Shigella (Zurawski et al., 2009).
References
Zurawski et al., 2009: Zurawski DV, Mumy KL, Faherty CS, McCormick BA, Maurelli AT. Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein. Molecular microbiology. 2009; 71(2); 350-368. [PubMed: 19017275].