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mxiA from Shigella dysenteriae Sd197

Victor ID 1504
Gene Name mxiA from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776541
NCBI Protein GI 82524591
Locus Tag SDY_P185
Protein Accession YP_406186.1
Other Database IDs UniProtKB-ID: Q326R0_SHIDS
UniRef100: UniRef100_Q326R0
UniRef90: UniRef90_P0A1I5
UniRef50: UniRef50_P0A1I5
UniParc: UPI00005E3A1B
EMBL: CP000035
EMBL-CDS: ABB64698.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000083990.
EnsemblGenome_TRS: EBESCT00000084944
EnsemblGenome_PRO: EBESCP00000081768
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P185
NMPDR: fig|216598.1.peg.2908
eggNOG: COG4789
HOGENOM: HBG595253
OMA: GRNIMSQ
ProtClustDB: CLSK862855
BioCyc: SDYS300267:SDY_P185-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 148835
Gene Ending Position 150901
Gene Strand (Orientation) +
Protein Name innermembrane protein, component of the Mxi-Spa secretion machinery
DNA Sequence 
>gi|82524407:148835-150901 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
GATGAAAGTGATCCAGTCTTTTCTTAAGCAAGTAAGTACTAAGCCTGAATTAATTATATTAGTGCTTATG
GTTATGATCATTGCTATGTTGATCATACCATTACCCACATACCTTGTTGATTTTTTAATAGGGCTTAATA
TTGTACTTGCTATTCTCGTTTTTATGGGATCATTTTATATTGAAAGAATATTGAGTTTTTCTACATTCCC
TTCGGTTTTGTTGATAACGACATTATTTCGTCTCGCTTTATCAATAAGTACTAGTCGGCTAATTTTAGTT
GATGCGGATGCGGGTAAAATTATTACTACATTTGGCCAGTTTGTCATTGGTGATAGTCTGGCTGTAGGTT
TTGTTATTTTTTCAATAGTAACTGTTGTGCAGTTCATTGTTATAACAAAAGGATCTGAAAGGGTTGCGGA
GGTAGCTGCTCGCTTTTCTCTTGACGGTATGCCGGGGAAACAAATGAGCATTGATGCGGATTTAAAGGCT
GGAATTATTGATGCCGCAGGAGCTAAAGAAAGACGCAGTATTCTGGAACGTGAGAGTCAATTGTATGGTT
CATTTGATGGAGCAATGAAGTTCATTAAAGGTGATGCAATTGCTGGCATCATTATTATTTTTGTCAATTT
AATAGGAGGTATTTCTGTTGGTATGAGTCAACATGGAATGTCCCTATCTGGTGCATTATCTACTTATACT
ATACTAACTATTGGTGACGGATTGGTCTCTCAGATTCCTGCTCTGTTAATTTCTATAAGTGCAGGATTTA
TCGTTACAAGAGTTAATGGTGATAGCGATAATATGGGACGTAACATAATGTCCCAGATATTTGGGAATCC
TTTTGTTCTCATTGTTACATCAGCTCTTGCCTTGGCGATAGGGATGTTGCCAGGTTTTCCGTTTTTTGTT
TTTTTCCTGATAGCAGTTACTTTGACGGCTTTATTCTATTATAAAAAGGTCGTAGAAAGAGAAAAAAGTC
TGTCTGAGTCTGATCCTAGTGGCTATACTGGTACATTTGATATTGATAATAGCCATGACTCATCTTTGGC
AATGATAGAAAATCTGGATGCTATTAGTTCAGAAACCGTTCCTTTAATTTTATTATTTGCCGAAAATAAG
ATAAATGCAAATGATATGGAGGGGCTTATTGAAAGGATAAGAAGTCAGTTCTTTATTGATTATGGTGTCA
GGCTTCCAACTATTTTATATAGAACAAGCAATGAGCTTAAGGTTGACGATATTGTTTTGTTAATAAATGA
GGTGCGTGCCGATAGTTTTAATATATACTTTGACAAAGTATGTATTACAGATGAGAATGGAGATATAGAT
GCTCTAGGTATTCCTGTTGTTCCAACTTCATATAATGAACGTGTTATTTCTTGGGTAGACGTTTCATATA
CAGAAAATCTAACTAATATTGATGCTAAAATTAAAAGCGCTCAAGATGAATTTTATTACCAGTTGTCACA
AGCCTTATTAAACAACATAAATGAGATTTTTGGCATACAAGAAACAAAAAATATGTTAGATCAGTTTGAA
AATCGGTATCCTGATCTTTTAAAGGAAGTCTTCCGACATGTGACTATACAGAGAATATCTGAGGTATTAC
AAAGATTGCTTGGAGAAAATATTTCTGTTCGCAATTTAAAACTTATTATGGAGTCTTTGGCGCTTTGGGC
TCCCAGAGAAAAAGATGTCATAACATTAGTTGAACATGTCCGTGCATCACTTTCTAGGTATATTTGTAGT
AAAATAGCCGTTTCTGGTGAGATTAAAGTTGTGATGCTTTCCGGATATATTGAGGATGCAATAAGAAAAG
GGATAAGGCAAACCTCTGGTGGCTCTTTCTTGAATATGGACATAGAGGTTTCGGATGAGGTAATGGAAAC
TTTAGCACATGCTTTGAGAGAATTGAGAAATGCAAAAAAAGATTTCGTTCTTTTGGTATCAGTAGATATA
CGTAGGTTTGTTAAAAGACTTATAGATAACAGATTTAAGAGTATACTCGTTATATCGTATGCTGAGATTG
ATGAAGCATATACCATTAATGTATTGAAGACTATTTA
Protein Sequence 
>gi|82524591|ref|YP_406186.1| MxiA [Shigella dysenteriae Sd197] MKVIQSFLKQVSTKPELIILVLMVMIIAMLIIPLPTYLVDFLIGLNIVLAILVFMGSFYIERILSFSTFPSVLLITTLFRLALSISTSRLILVDADAGKIITTFGQFVIGDSLAVGFVIFSIVTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLKAGIIDAAGAKERRSILERESQLYGSFDGAMKFIKGDAIAGIIIIFVNLIGGISVGMSQHGMSLSGALSTYTILTIGDGLVSQIPALLISISAGFIVTRVNGDSDNMGRNIMSQIFGNPFVLIVTSALALAIGMLPGFPFFVFFLIAVTLTALFYYKKVVEREKSLSESDPSGYTGTFDIDNSHDSSLAMIENLDAISSETVPLILLFAENKINANDMEGLIERIRSQFFIDYGVRLPTILYRTSNELKVDDIVLLINEVRADSFNIYFDKVCITDENGDIDALGIPVVPTSYNERVISWVDVSYTENLTNIDAKIKSAQDEFYYQLSQALLNNINEIFGIQETKNMLDQFENRYPDLLKEVFRHVTIQRISEVLQRLLGENISVRNLKLIMESLALWAPREKDVITLVEHVRASLSRYICSKIAVSGEIKVVMLSGYIEDAIRKGIRQTSGGSFLNMDIEVSDEVMETLAHALRELRNAKKDFVLLVSVDIRRFVKRLIDNRFKSILVISYAEIDEAYTINVLKTI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mxiA mutants were attenuated in invasion of HeLa cells (Andrews et al., 1991).
COG COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Andrews et al., 1991: Andrews GP, Hromockyj AE, Coker C, Maurelli AT. Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens. Infection and immunity. 1991; 59(6); 1997-2005. [PubMed: 2037361].