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mxiC from Shigella dysenteriae Sd197

Victor ID 1503
Gene Name mxiC from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776540
NCBI Protein GI 82524590
Locus Tag SDY_P184
Protein Accession YP_406185.1
Other Database IDs UniProtKB-ID: Q326R1_SHIDS
UniRef100: UniRef100_Q326R1
UniRef90: UniRef90_Q04640
UniRef50: UniRef50_Q04640
UniParc: UPI00005E3A1A
EMBL: CP000035
EMBL-CDS: ABB64697.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000084006.
EnsemblGenome_TRS: EBESCT00000084960
EnsemblGenome_PRO: EBESCP00000081784
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P184
NMPDR: fig|216598.1.peg.2909
eggNOG: NOG04987
HOGENOM: HBG683617
OMA: SRASHED
ProtClustDB: CLSK505058
BioCyc: SDYS300267:SDY_P184-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 147821
Gene Ending Position 148828
Gene Strand (Orientation) +
Protein Name secreted by and putative component of the Mxi-Spa secretion machinery, similar to YopN (secreted by the type III secretion machinery of Yersinia enterocoltica)
DNA Sequence 
>gi|82524407:147821-148828 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
AATGACAAATTCAGATGATGGAGATGAGACTGCTGATGCAGAGCTTGATTCTGGCTTGGCTAATAGCAAG
TATATTGACTCATCTGATGAGATGGCTTCCGCTCTTTCGTCATTCATAAACAGAAGAGACCTTGAGAAAC
TGAAAGGAACAAATAGTGATAGTCAGGAGCGTATTTTAGATGGGGAAGAAGATGAAATTAATCACAAGAT
TTTTGATTTAAAGAGAACTTTAAAAGATAACCTTCCTCTAGATCGGGATTTTATAGACAGACTAAAGAGA
TATTTTAAAGATCCAAGCGATCAAGTCTTAGCATTAAGGGAACTTTTGAATGAAAAAGATCTTACTGCTG
AACAAGTCGAATTATTAACTAAAATTATTAATGAGATAATATCAGGTAGTGAAAAAAGTGTTAATGCTGG
AATAAATTCAGCTATACAGGCTAAATTATTTGGCAACAAAATGAAACTTGAACCACAGCTTTTGCGTGCA
TGTTATCGTGGTTTTATCATGGGGAACACATCAACAACAGATCAGTATATAGAATGGCTTGGTAATTTTG
GTTTTAATCACAGGCATACAATTGTGAATTTTGTAGAGCAGTCACTGATTGTAGACATGGATTCTGAGAA
ACCGAGCTGTAATACTTATGAGTTTGGTTTTGTGTTATCTAAATTAATTGCAATTAAGATGATTAGAACT
TCAGACGTAATTTTTATGAAGAAACTGGAATCCTCAAGCTTGCTAAAAGATGGCAGTTTAAGTGCAGAGC
AGCTATTGCTAACTTTATTATATATTTTTCAATATCCAAGTGAAAGTGAGCAAATTCTTACTTCTGTTAT
AGAAGTATCACGAGCCAGTCATGAGGATTCTGTAGTGTATCAAACATATCTATCTTCTGTTAATGAAAGT
CCTCATGATATATTTAAAAGTGAAAGTGAAAGAGAAATTGCGATCAATATTCTACGAGAGCTTGTCACAA
GTGCATACAAGAAAGAGCTTTCTAGATA
Protein Sequence 
>gi|82524590|ref|YP_406185.1| MxiC [Shigella dysenteriae Sd197] MTNSDDGDETADAELDSGLANSKYIDSSDEMASALSSFINRRDLEKLKGTNSDSQERILDGEEDEINHKIFDLKRTLKDNLPLDRDFIDRLKRYFKDPSDQVLALRELLNEKDLTAEQVELLTKIINEIISGSEKSVNAGINSAIQAKLFGNKMKLEPQLLRACYRGFIMGNTSTTDQYIEWLGNFGFNHRHTIVNFVEQSLIVDMDSEKPSCNTYEFGFVLSKLIAIKMIRTSDVIFMKKLESSSLLKDGSLSAEQLLLTLLYIFQYPSESEQILTSVIEVSRASHEDSVVYQTYLSSVNESPHDIFKSESEREIAINILRELVTSAYKKELSR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mxiC mutant has a 10-fold decrease in efficiency in invading epithelial cells (Botteaux et al., 2009).
References
Botteaux et al., 2009: Botteaux A, Sory MP, Biskri L, Parsot C, Allaoui A. MxiC is secreted by and controls the substrate specificity of the Shigella flexneri type III secretion apparatus. Molecular microbiology. 2009; 71(2); 449-460. [PubMed: 19017268].