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mxiG from Shigella dysenteriae Sd197

Victor ID 1494
Gene Name mxiG from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776530
NCBI Protein GI 82524580
Locus Tag SDY_P174
Protein Accession YP_406175.1
Other Database IDs UniProtKB-ID: Q326S1_SHIDS
UniRef100: UniRef100_Q326S1
UniRef90: UniRef90_P0A221
UniRef50: UniRef50_P0A221
UniParc: UPI00005E3A10
EMBL: CP000035
EMBL-CDS: ABB64687.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000083892.
EnsemblGenome_TRS: EBESCT00000084846
EnsemblGenome_PRO: EBESCP00000081670
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P174
NMPDR: fig|216598.1.peg.2912
eggNOG: NOG13450
HOGENOM: HBG683613
OMA: FPYINLY
ProtClustDB: CLSK688132
BioCyc: SDYS300267:SDY_P174-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 140909
Gene Ending Position 142024
Gene Strand (Orientation) +
Protein Name component of the Mxi-Spa secretion machinery, contains one transmembrane segment
DNA Sequence 
>gi|82524407:140909-142024 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
TATGTCTGAGGCAAAGAACTCAAATCTTGCACCATTCAGGTTATTAGTGAAACTCACAAACGGTGTCGGG
GATGAGTTTCCGTTGTATTATGGGAATAACTTAATTGTTCTCGGACGGACGATAGAAACACTTGAGTTTG
GAAACGACAATTTCCCAGAAAATATTATTCCTGTAACAGATAGTAAATCGGATGGTATAATTTATTTGAC
CATAAGCAAAGATAATATCTGTCAATTTAGTGATGAAAAAGGTGAGCAAATTGATATCAATTCACAATTT
AATTCATTTGAATATGACGGGATTTCTTTTCACCTTAAAAATATGAGGGAGGATAAATCGAGAGGTCATA
TACTAAACGGAATGTATAAGAACCCCTCGGTGTTTTTTTTCTTTGCTGTTATTGTTGTGTTAATTATAAT
TTTTTCCCTCTCTTTAAAGAAAGATGAAGTAAAAGAAATTGCTGAAATTATAGATGATAATAGATATGGA
ATAGTCAACACTGGACAGTGCAATTATATTCTTGCCGAAACACAAAATGATGCGGTATGGGCATCTGTAG
CCTTAAATAAAACCGGATTTACCAAATGCAGATATATTCTGGTGTCAAACAAAGAAATAAATAGAATTCA
ACAATATATCAATCAACGATTTCCATATATCAATTTGTATGTGTTGAATTTAGTGAGTGATAAAGCGGAA
TTACTGGTGTTTTTAAGTAAAGAAAGAAATAGTTCAAAGGATACCGAACTTGATAAATTGAAAAATGCTC
TGATTGTTGAATTTCCGTATATCAAAAATATTAAATTCAACTATCTTAGCGATCATAATGCAAGGGGGGA
TGCTAAAGGTATTTTCACAAAGGTAAATGTCCAGTATAAAGAGATTTGTGAAAATAATAAAGTTACATAT
TCTGTCAGAGAAGAACTGACAGATGAAAAGCTTGAGCTCATTAATAGACTGATTTCTGAACATAAAAATA
TATATGGAGATCAGTATATTGAGTTTTCTGTACTTTTGATAGATGATGATTTTAAAGGTAAATCATATCT
TAACAGCAAAGACAGTTATGTAATGTTGAATGATAAACATTGGTTTTTTTTAGATAAAAATAAGTG
Protein Sequence 
>gi|82524580|ref|YP_406175.1| MxiG [Shigella dysenteriae Sd197] MSEAKNSNLAPFRLLVKLTNGVGDEFPLYYGNNLIVLGRTIETLEFGNDNFPENIIPVTDSKSDGIIYLTISKDNICQFSDEKGEQIDINSQFNSFEYDGISFHLKNMREDKSRGHILNGMYKNPSVFFFFAVIVVLIIIFSLSLKKDEVKEIAEIIDDNRYGIVNTGQCNYILAETQNDAVWASVALNKTGFTKCRYILVSNKEINRIQQYINQRFPYINLYVLNLVSDKAELLVFLSKERNSSKDTELDKLKNALIVEFPYIKNIKFNYLSDHNARGDAKGIFTKVNVQYKEICENNKVTYSVREELTDEKLELINRLISEHKNIYGDQYIEFSVLLIDDDFKGKSYLNSKDSYVMLNDKHWFFLDKNK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mxiG mutant was unable to enter HeLa cells and to provoke keratoconjunctivitis in guinea-pigs (Allaoui et al., 1995).
References
Allaoui et al., 1995: Allaoui A, Sansonetti PJ, Ménard R, Barzu S, Mounier J, Phalipon A, Parsot C. MxiG, a membrane protein required for secretion of Shigella spp. Ipa invasins: involvement in entry into epithelial cells and in intercellular dissemination. Molecular microbiology. 1995; 17(3); 461-470. [PubMed: 8559065].