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ipgD from Shigella dysenteriae Sd197

Victor ID 1493
Gene Name ipgD from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776527
NCBI Protein GI 82524577
Locus Tag SDY_P171
Protein Accession YP_406172.1
Other Database IDs UniProtKB-ID: Q326S4_SHIDS
UniRef100: UniRef100_Q939N1
UniRef90: UniRef90_Q07566
UniRef50: UniRef50_Q07566
UniParc: UPI00000BE2AA
EMBL: CP000035
EMBL-CDS: ABB64684.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000083928.
EnsemblGenome_TRS: EBESCT00000084882
EnsemblGenome_PRO: EBESCP00000081706
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P171
NMPDR: fig|216598.1.peg.2913
eggNOG: NOG29401
HOGENOM: HBG671713
OMA: NSSERAV
ProtClustDB: CLSK862850
BioCyc: SDYS300267:SDY_P171-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 138454
Gene Ending Position 140070
Gene Strand (Orientation) +
Protein Name secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells
DNA Sequence 
>gi|82524407:138454-140070 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
AATGCACATAACTAATTTGGGATTGCATCAGGTTTCATTTCAAAGCGGAGATTCCTATAAAGGCGCAGAA
GAAACCGGAAACCAAAAAAGTGTAAGCGTGATTTCATATCAAAGAGTTAAAAATGGAGAGAGAAATAAGG
GGGTCGAAGCGCTTAATCGATTATATTTACAGAACCAAACAAGCTTAACAGGGAAAGGCCTTTTGTTTGC
GCGTGACAGAGCTGCAGTTTTTTACGAGGCAATAAAGTTGGCAGGTGGTGATACGTCAAAAATTAAAGCC
ATGATGGAACAATTAGATACCTATAAACTTGGTGAAGTTGATAAAAGAAATATTAATGAGCTTAATAAAG
TAATAAGTGAAGAGATAAGAGCACAGCTAGGCATTAAAAATAAAAAGGAATTGCAATCGGAAATAAAACA
AATATTTACTAATCATTTAAATAATAAGAATTGGGAACCGATCAACAAAAATATTAATTATCATGGGAAA
AATTATGGTTTTCAATTAACACCCGCCTCTCATATGAAGATAGGGAATAAAAATATATTTGTCAAAGAGT
ATAATGGAAAAGGAATTTGTTGTGCTTCTACTAGAGAGAGTCAGCATATTGCGAATATGTGGCTTTCAAA
AGTGGTGGATGACGAGGGGAAGGAAATTTTTTCGGGTATCAGACATGGAGTTATATCAGCCTATGGATTG
AAAAAAAACTCATCTGAAAGAGCTGTTGCTGCTCGTAATAAAGCTGAGGAGTTAGCAAGCGCAGCATTAT
ATAGCAGACGAGAATTATTATCACAGGCTTTGTCTGGTAAAACAGTAGATTTAAAGATTGTTTCGACTTC
TCTTCTGACGCCGACCAGTTTAACCGGGGGAGAGGAGAGTATGTTAAAAGATCAGGTAAAGGCATTAAAA
GGGTTAAACTCTAAAAGGGGGGAACCAACGAAATTATTAATTCGGAATAGTGATGGTCTTCTGCAAGAAG
TAAACGTTAATCTAAAAGTGGTGACATTTAACTTTGGTGTAAATGAATTAGCGCTAAAAATGGGCTTAGG
CTGGAGGAATGTTGACAAGCTTAATGGTGAATCAATATGTTCTTTGTTGGGGGATAATTTCCTCAAAAAT
GGTGTGATTGGAGGTTGGGCAGCAGAAGCTATAGAAAAAAATCCATCATGTAAGAATGATGTGATATATC
TGGCTAACCAGATAAAAGAGATTCTAAACAAGAAGTTACAAAAAAATGATAATGGAGAGCCGTATAAATT
GTCACAAAGAATGGCGCTATTGGCTTATACTATAGGTGCTGTACCTTGCTGGAATTGTAAGAGTGGGAAG
GACAGAACAGGTATGCAGGATGCTGAAATTAAAAGAGAAATAATAAGAAAACATGAAACAGGGCAGTTTT
CTCAATTAAATAGTAAATTATCCTCAGAAGAGAAAAGATTATTTTCTACTATTCTAATGAATAGTGGTAA
TATGGAAATCCAAGAGATGAATACTGGTGTGCCTGGAAATAAAGTTATGAAAAAATTACCGCTATCTTCG
TTAGAGCTGTCTTATGCTGAAAGAATAGGGGACCCCAAAATATGGAATATGGTGAAAGGGTATTCGTCAT
TTGTATA
Protein Sequence 
>gi|82524577|ref|YP_406172.1| IpgD [Shigella dysenteriae Sd197] MHITNLGLHQVSFQSGDSYKGAEETGNQKSVSVISYQRVKNGERNKGVEALNRLYLQNQTSLTGKGLLFARDRAAVFYEAIKLAGGDTSKIKAMMEQLDTYKLGEVDKRNINELNKVISEEIRAQLGIKNKKELQSEIKQIFTNHLNNKNWEPINKNINYHGKNYGFQLTPASHMKIGNKNIFVKEYNGKGICCASTRESQHIANMWLSKVVDDEGKEIFSGIRHGVISAYGLKKNSSERAVAARNKAEELASAALYSRRELLSQALSGKTVDLKIVSTSLLTPTSLTGGEESMLKDQVKALKGLNSKRGEPTKLLIRNSDGLLQEVNVNLKVVTFNFGVNELALKMGLGWRNVDKLNGESICSLLGDNFLKNGVIGGWAAEAIEKNPSCKNDVIYLANQIKEILNKKLQKNDNGEPYKLSQRMALLAYTIGAVPCWNCKSGKDRTGMQDAEIKREIIRKHETGQFSQLNSKLSSEEKRLFSTILMNSGNMEIQEMNTGVPGNKVMKKLPLSSLELSYAERIGDPKIWNMVKGYSSFV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipgD mutant is unable to dephosphorylate phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] and induces shorter filapodia in host cells (Niebuhr et al., 2002).
References
Niebuhr et al., 2002: Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B. Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. The EMBO journal. 2002; 21(19); 5069-5078. [PubMed: 12356723].