Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

icsP

Victor ID 1488
Gene Name icsP
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776504
NCBI Protein GI 161986648
Locus Tag SDY_P224
Protein Accession YP_406225.2
Other Database IDs UniProtKB-ID: Q326M1_SHIDS
UniRef100: UniRef100_Q326M1
UniRef90: UniRef90_O33641
UniRef50: UniRef50_O33641
UniParc: UPI00005E3A36
EMBL: CP000035
EMBL-CDS: ABB64737.1
RefSeq_NT: NC_007607.1
MEROPS: A26.005
EnsemblGenome: EBESCG00000084045.
EnsemblGenome_TRS: EBESCT00000084999
EnsemblGenome_PRO: EBESCP00000081823
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P224
NMPDR: fig|216598.1.peg.3934
eggNOG: COG4571
HOGENOM: HBG468061
OMA: NSASIEY
ProtClustDB: PRK10993
BioCyc: SDYS300267:SDY_P224-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 181407
Gene Ending Position 182354
Gene Strand (Orientation) +
Protein Name SopA; outermembrane protease of the OmpP family, involved in cleavage of surface exposed IcsA
DNA Sequence 
>gi|82524407:181407-182354 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
GATGAAATTAAAATTCCTTGTACTTGCACTTTGTGTACCTGCGATCTTTACTACACATGCTACCACTAAC
TATCCACTTTTCATACCGGACAACATCAGTACGGATATTAGTCTAGGATCTCTGAGTGGCAAAACAAAAG
AACGCGTTTATCATCCCAAGGAAGGGGGGAGAAAAATTAGTCAACTGGACTGGAAATACAGTAATGCGAC
TATTGTTAGAGGTGGCATCGATTGGAAGCTAATTCCAAAAGTGTCTTTCGGAGTTTCCGGTTGGACTACT
TTAGGTAACCAGAAAGCAAGCATGGTTGATAAAGACTGGAACAATTCCAATACCCCTCAGATATGGACCG
ACCAGAGCTGGCATCCCAATACGCATCTCCGTGATGCTAACGAATTCGAGCTGAATCTTAAAGGTTGGTT
ATTAAATAATTTGGATTATCGACTTGGACTAATAGCAGGTTACCAAGAGAGTCGTTACAGTTTTAATGCA
ATGGGAGGGAGTTATATTTATAGTGAAAACGGGGGGAACAGGAATAAAAAAGGGGCACATCCTAGTGGTG
AAAGAACAATAGGTTACAAACAGCTCTTCAAAATACCTTATATTGGATTAACTGCTAATTACCGCCATGA
GAATTTTGAGTTTGGAGCAGAACTGAAATATAGTGGTTGGGTTCGTTCATCTGATACAGATAAACACTAT
CAGACTGAGACAATTTTTAAAGATGAAATAAAAAACCAAAATTACCGCTCTGTTGCTGCAAATATTGGAT
ACTATGTCACCCCCAGTGCAAAATTTTATATAGAAGGATCCAGAAATTACATTTCTAATAAAAAAGGTGA
TACATCTCTTTATGAGCAAAGTACCAATATATCTGGCACCATTAAAAATAGTGCAAGTATTGAATATATT
GGTTTTCTCACTTCCGCAGGTATAAAGTATATTTTTTG
Protein Sequence 
>gi|161986648|ref|YP_406225.2| outer membrane protease [Shigella dysenteriae Sd197] MKLKFLVLALCVPAIFTTHATTNYPLFIPDNISTDISLGSLSGKTKERVYHPKEGGRKISQLDWKYSNATIVRGGIDWKLIPKVSFGVSGWTTLGNQKASMVDKDWNNSNTPQIWTDQSWHPNTHLRDANEFELNLKGWLLNNLDYRLGLIAGYQESRYSFNAMGGSYIYSENGGNRNKKGAHPSGERTIGYKQLFKIPYIGLTANYRHENFEFGAELKYSGWVRSSDTDKHYQTETIFKDEIKNQNYRSVAANIGYYVTPSAKFYIEGSRNYISNKKGDTSLYEQSTNISGTIKNSASIEYIGFLTSAGIKYIF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sopA mutant was able to infect HeLa cells, but was attenuated in its ability to spread to other cells compared to the wild type (Egile et al., 1997).
COG COG4571M, under M: Cell wall/membrane/envelope biogenesis
References
Egile et al., 1997: Egile C, d'Hauteville H, Parsot C, Sansonetti PJ. SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri. Molecular microbiology. 1997; 23(5); 1063-1073. [PubMed: 9076742].