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virA from Shigella dysenteriae Sd197

Victor ID 1486
Gene Name virA from Shigella dysenteriae Sd197
Sequence Strain (Species/Organism) Shigella dysenteriae Sd197
NCBI Gene ID 3776491
NCBI Protein GI 82524617
Locus Tag SDY_P211
Protein Accession YP_406212.1
Other Database IDs UniProtKB-ID: VIRA_SHIDS
UniRef100: UniRef100_Q326N4
UniRef90: UniRef90_Q326N4
UniRef50: UniRef50_Q3YTK0
UniParc: UPI00005E3A2D
EMBL: CP000035
EMBL-CDS: ABB64724.1
RefSeq_NT: NC_007607.1
EnsemblGenome: EBESCG00000083941
EnsemblGenome_TRS: EBESCT00000084895
EnsemblGenome_PRO: EBESCP00000081719
GenomeReviews: CP000035_GR
KEGG: sdy:SDY_P211
NMPDR: fig|216598.1.peg.5626
HOGENOM: HBG683626
OMA: AHANIDG
ProtClustDB: CLSK505080
BioCyc: SDYS300267:SDY_P211-MONOMER
Taxonomy ID 300267
Plasmid No pSD1_197
Gene Starting Position 167851
Gene Ending Position 169053
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|82524407:167851-169053 Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequence
CTTAAACATCAGGAGATATGATGGCAAATGATACTTGACGACTTTCTGGAGGGATAGCATTGCGAAGCCC
TTCACTGCTTGGAAGTGTTCCAGCATGAACGAGATAGCTTGTTTCTATTTTATTAATACCAACACCATTA
CATGTTATGTGCGATGGTAATATTGATGAGCTAACTTCGTAAGCCCTCCCCCCAGAGGCAGAGATTGCAG
TGTCGTTTTTAGGGACAACTGCGTTGATTTTTATAATATGTCCACAATTGTTAATAACTCGTTGTTCAGG
CATGAAATTAAGCCTGTTTTCTATGTTTTCGGACATAATTTGGGCATATATGTGTTCCACAGAGGAAGAC
GTGATGTGAAGAGATTGCCAGAATGCAGATGTTAGTGCAGATATAAATGCAGGGTCTTGAAAGAGTGAAG
TAAACAAAAGTTTTTCTGTTTGAAAACATAGGTCTTGTTGGGGGAAGTTTGAATTGATTATTTTATTTAC
TTGGTTGTAACTTAGCATTTGAAGCTCTTTTTTGCTATCAATGAATTCATTAATTCCTAACTCATTAATT
AGATCTGCAATTAATTTTAGTGGTATTTCAATATTGTTGAAATATATTTTTGTACTATTGCTGTCAGATG
CTCGAATATCTCTGTAAATATCATGCCAAACACTATTAAAATCAGTGTCTTTAACGGAGAAGTAATCATC
GTTTGGTATTATCGATGTGCAGCAATTAATGGCTGTTTCAATAACTTCTGGTGCAGGCTTGTGAGTTTTA
AAATTCCCTGATACCGGAGCTGTAATAGTATGTACTTTTCCTAAGTTGAATTGTTTGGGGGGGAGTGAAC
TTAACAAGTTATTATATTCTTTTGATGAAAGTTGAGTGGATTGTATTTTATCTCCATCAAGATAAAATAC
CGAACATATGCCTTTGTTAAGGCATAGCCGTATTGAAATGCCATCTATGTTTGCGTGGGCAAACTCTCCG
TCCATTTTATCTTGTGATAGTGATGGTGAGAAACTATCCATTAGTTTTTTTTCGCTATATTTTTCGGCTA
GAGTTTCGTGTGGAGAATATATGCCGAAAGTTATTATTTTCAGTAAAACGTCACAAAAACTCAATTTATT
CCAACTTACTTCTGTAGTTGATTTGACAGTTGACATCCATGATGAGTCATTTCTTTCATAGTTAGTTATG
TTTGATGTCTGCA
Protein Sequence 
>gi|82524617|ref|YP_406212.1| VirA [Shigella dysenteriae Sd197] MQTSNITNYERNDSSWMSTVKSTTEVSWNKLSFCDVLLKIITFGIYSPHETLAEKYSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKGICSVFYLDGDKIQSTQLSSKEYNNLLSSLPPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFSVKDTDFNSVWHDIYRDIRASDSNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQMLSYNQVNKIINSNFPQQDLCFQTEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPEQRVINNCGHIIKINAVVPKNDTAISASGGRAYEVSSSILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPESRQVSFAIISPDV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virA mutants did not move within the host cytoplasm and failed to move into adjacent cells (Yoshida et al., 2006).
References
Yoshida et al., 2006: Yoshida S, Handa Y, Suzuki T, Ogawa M, Suzuki M, Tamai A, Abe A, Katayama E, Sasakawa C. Microtubule-severing activity of Shigella is pivotal for intercellular spreading. Science (New York, N.Y.). 2006; 314(5801); 985-989. [PubMed: 17095701].