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gnd from Brucella melitensis bv. 1 str. 16M

Victor ID 1405
Gene Name gnd from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1198896
NCBI Protein GI 17989469
Locus Tag BMEII1124
Protein Accession NP_542102.1
Other Database IDs UniProtKB-ID: D0B5W0_BRUME
UniRef100: UniRef100_D0B5W0
UniRef90: UniRef90_A6X6S9
UniRef50: UniRef50_A6UA87
UniParc: UPI0000058751
EMBL: GG703779
EMBL-CDS: EEW87002.1
RefSeq_NT: NC_003318.1
OMA: LQGQRDF
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 1160219
Gene Ending Position 1161628
Gene Strand (Orientation) -
Protein Name 6-phosphogluconate dehydrogenase
DNA Sequence 
>gi|17988344:1160219-1161628 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
CTCAGCCCCAGGGGCCGTGGAAATCCCCCTCCTTGTCAATGCGCTTGAAGCCGTGCGAGCCGAAGAAATC
GCGCTGGCCCTGAATGAGATTGGCCGTACCAAGCGCCTGCGTATAGCTGTCGAAATAGCTGAGCGCAGAG
CCGAGCGCGGGCAGCGGCAGGCTGGCAAGGGCGGCCTGCGCGACAATCTGGCGAAGGCTTTTCACAGATG
TTTCCATGCGCGGCACGAAGGCCGGGGCCATGAGCAGGTTGCGGCTTTCATTGCCTTCAAAAGCCTGCGC
AATATCATCCAGAAGCTGCGAGCGGATGATGCAGCCCGCGCGCCAGATGCGCGCCGTGGTGGCAAGCGGA
ATGTTCCAGCCATGCTCCCTTGAGGCGGCTTCCATCACTGCAAAGCCTTGCGCATAAGCGGCGATCTTGC
CCGCCAGCAAGCCCTGTTCCAGATCGGAAAGGAAGCGGGTCTGGTTGGCAATATCAAGTGTGCGTGCACC
GGATTTATACGCCTTGTCGGCCTCTTCCCGCTCGCCCTTCATGGAGGACAGCGAACGGGCGGCAACCGCG
GCTTCGATGCCCGTGGCAGGAACGCCCAGTATCTGCGCCTCAATGGCAGCCCAGCGGCCTGTACCCTTCT
GGCCGGCTTCATCAAGGATCATATCGACCATCGCCTTGCCGGTTTCCGGGTCGGTGGACTTGAGAACCTT
GGCGGTGATTTCAATCAGATAGGAATTGAGCGGACCTTCGTTCCACTTCTCGAACACATCGCCGATGGCC
GGAGCTGAAAGGCCAAGGCCATCGCGCAGAATGCCGTAAATTTCGGCGATCATCTGCATATCGGCATATT
CAATACCGTTATGGATGGTTTTGACGAAATGACCCGCGCCATCCGGGCCGACCAGCGCACAGCAGGGCTC
GCCCTGATATTTGGCGGCGACAGCAAGCAGGATCGGCGCGATGCGCTCATAGGCCTGCTCCGTGCCGCCG
ACCATCATCGACGGACCATGGCGCGCGCCTTCCGCCCCACCCGAAACGCCCATGCCGACAAAGGTCGGAT
CATTGGGGCCAAGAGCCTTCAGGCGGCGCACCGTATCGCGATAATCGGAATTGCCTGCATCGATCATGAT
ATCGCCCTTCTCAAGGAATGCCTTAAGGCGGGTGGTCTCGGTATCGACTGGCGCACCGGCCTTGATGAGA
AAGATGATCGGACGGGGCTTGCGGATATTCGCGGCCAGTTCCTCAAAGGTCGGGCAGGGAATGATCTTGT
CGCGCAGCCGGCCAGCCTTTTCGATGAAAGCTTTCAGCACAGGCTCATCACGGTCATAGACGGCCACGGT
GTAGCCCTTCTCGGCTATGTTCAGCGCCAGGTTGGAGCCCATGACGCCAAGGCCGACCATTCCGATATCT
GCTTTTTCCA
Protein Sequence 
>gi|17989469|ref|NP_542102.1| 6-phosphogluconate dehydrogenase [Brucella melitensis bv. 1 str. 16M] MEKADIGMVGLGVMGSNLALNIAEKGYTVAVYDRDEPVLKAFIEKAGRLRDKIIPCPTFEELAANIRKPRPIIFLIKAGAPVDTETTRLKAFLEKGDIMIDAGNSDYRDTVRRLKALGPNDPTFVGMGVSGGAEGARHGPSMMVGGTEQAYERIAPILLAVAAKYQGEPCCALVGPDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGLSAPAIGDVFEKWNEGPLNSYLIEITAKVLKSTDPETGKAMVDMILDEAGQKGTGRWAAIEAQILGVPATGIEAAVAARSLSSMKGEREEADKAYKSGARTLDIANQTRFLSDLEQGLLAGKIAAYAQGFAVMEAASREHGWNIPLATTARIWRAGCIIRSQLLDDIAQAFEGNESRNLLMAPAFVPRMETSVKSLRQIVAQAALASLPLPALGSALSYFDSYTQALGTANLIQGQRDFFGSHGFKRIDKEGDFHGPWG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gnd is involved in pentose phosphate pathway. It is essential for intracellular growth inside HeLa cells as shown by its Brucella suis miniTn5Km2 transposon mutation analysis. The mutant is attenuated in the mouse model (Kim et al., 2003).
COG COG0362G, under G: Carbohydrate transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].