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gluP from Brucella melitensis bv. 1 str. 16M

Victor ID 1399
Gene Name gluP from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1198825
NCBI Protein GI 17989398
Locus Tag BMEII1053
Protein Accession NP_542031.1
Other Database IDs UniProtKB-ID: GLUP_BRUME
UniRef100: UniRef100_Q8YB48
UniRef90: UniRef90_Q2YIJ8
UniRef50: UniRef50_Q2YIJ8
UniParc: UPI000005870A
EMBL: AE008918
EMBL-CDS: AAL54295.1
RefSeq_NT: NC_003318.1
GenomeReviews: AE008918_GR
KEGG: bme:BMEII1053
NMPDR: fig|224914.1.peg.3113
HOGENOM: HBG735535
OMA: KYLAFNA
ProtClustDB: CLSK2303108
BioCyc: BMEL224914:BMEII1053-MONOMER
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 1094523
Gene Ending Position 1095761
Gene Strand (Orientation) +
Protein Name GLUCOSE/GALACTOSE TRANSPORTER
DNA Sequence 
>gi|17988344:1094523-1095761 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
TATGGCAACTTCCATCCCAACGAATAATCCGCTGCACACTGAAACCTCCTCCCAGAAAAATTACGGTTTC
GCGCTCACCAGCCTCACCTTGCTGTTTTTCATGTCGGGCTTCATCACCTGTCTCAACGACATCCTGATCC
CGCATCTAAAGAACGTTTTCCAGCTCAACTATACCCAGTCGATGCTGATCCAGTTCTGCTTCTTCGGGGC
CTATTTCATCGTTTCCCTGCCCGCAGGGCAGCTTGTAAAGCGCATTTCCTATAAGTGTGGCATCGTCGTC
GGCCTCATCGTGGCGGCAATCGGCTGCGCGCTTTTCATCCCGGCCGCGTCATACCGCGTCTATGCGCTGT
TCCTCGGCGCGCTCTTCGTGCTTGCGTCCGGCGTTACGATCCTTCAGGTTGCCGCCAATCCCTATGTGAC
GATCCTTGGCAAGCCTGAAACCGCCGCAAGCCGCCTGACACTGACACAGGCCTTCAACTCGCTCGGCACC
ACGGTTGCGCCGGTCTTTGGCGCAGTCCTGATCCTTTCAGCGGCAACGGACGCCACCGTCAATGCCGAAG
CCGACGCGGTTCGCTTCCCATATCTTCTTCTGGCGCTTGCCTTCACGGTTCTTGCCATCATCTTTGCAAT
CCTGAAACCGCCGGATGTGCAGGAAGACGAACCCGCCCTTTCCGACAAGAAAGAGGGCAGCGCCTGGCAA
TATCGCCACCTGGTTCTGGGAGCGATCGGCATTTTCGTGTACGTCGGCGCTGAGGTCAGCGTCGGCAGCT
TCCTCGTGAATTTCCTGAGCGATCCCACCGTTGCTGGCCTCTCCGAAACCGATGCCGCCCATCACGTGGC
CTATTTCTGGGGCGGGGCCATGGTGGGCCGCTTCATCGGCTCGGCAGCCATGCGTTATATCGATGACGGC
AAGGCCCTTGCCTTCAACGCATTTGTCGCCATCATCCTGCTGTTCATCACCGTTGCCACCACGGGCCATA
TCGCCATGTGGTCGGTGCTGGCCATCGGGCTGTTCAATTCGATCATGTTCCCCACGATCTTCAGCCTCGC
CTTGCATGGCCTTGGCAGCCACACCAGCCAGGGTTCCGGCATTTTGTGCCTGGCCATCGTCGGCGGCGCG
ATTGTTCCGCTGATCCAGGGCGCATTGGCTGATGCGATCGGCATTCATCTTGCCTTCCTGATGCCGATCA
TCTGCTATGCCTATATCGCCTTCTATGGCCTCATCGGCAGCAAAAGCTG
Protein Sequence 
>gi|17989398|ref|NP_542031.1| glucose/galactose transporter [Brucella melitensis bv. 1 str. 16M] MATSIPTNNPLHTETSSQKNYGFALTSLTLLFFMSGFITCLNDILIPHLKNVFQLNYTQSMLIQFCFFGAYFIVSLPAGQLVKRISYKCGIVVGLIVAAIGCALFIPAASYRVYALFLGALFVLASGVTILQVAANPYVTILGKPETAASRLTLTQAFNSLGTTVAPVFGAVLILSAATDATVNAEADAVRFPYLLLALAFTVLAIIFAILKPPDVQEDEPALSDKKEGSAWQYRHLVLGAIGIFVYVGAEVSVGSFLVNFLSDPTVAGLSETDAAHHVAYFWGGAMVGRFIGSAAMRYIDDGKALAFNAFVAIILLFITVATTGHIAMWSVLAIGLFNSIMFPTIFSLALHGLGSHTSQGSGILCLAIVGGAIVPLIQGALADAIGIHLAFLMPIICYAYIAFYGLIGSKS
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Intake of glucose and galactose (Potential)(UniProt: Q8YB48).

SUBCELLULAR LOCATION: Inner membrane; multi-pass membrane protein (Probable)(UniProt: Q8YB48).

SIMILARITY: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family(UniProt: Q8YB48).

MUTATION: B suis and maybe B canis seem to have two glucosegalactose transporters: gluP and gguAB. B abortus may express only gluP, which may explain why gluP mutants fail to survive long periods in the mouse (Essenberg et al., 2002).
COG COG0738G, under G: Carbohydrate transport and metabolism
References
Essenberg et al., 2002: Essenberg RC, Seshadri R, Nelson K, Paulsen I. Sugar metabolism by Brucellae. Veterinary microbiology. 2002; 90(1-4); 249-261. [PubMed: 12414147].