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narG from Brucella melitensis bv. 1 str. 16M

Victor ID 1395
Gene Name narG from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1198722
NCBI Protein GI 17989295
Locus Tag BMEII0950
Protein Accession NP_541928.1
Other Database IDs UniProtKB-ID: Q8YBF0_BRUME
UniRef100: UniRef100_Q8YBF0
UniRef90: UniRef90_Q8YBF0
UniRef50: UniRef50_P09152
UniParc: UPI00000586A3
EMBL: AE008918
EMBL-CDS: AAL54192.1
RefSeq_NT: NC_003318.1
HSSP: P09152
GenomeReviews: AE008918_GR
KEGG: bme:BMEII0950
NMPDR: fig|224914.1.peg.3010
HOGENOM: HBG496975
OMA: SGIESEH
ProtClustDB: CLSK868288
BioCyc: BMEL224914:BMEII0950-MONOMER
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 987987
Gene Ending Position 990764
Gene Strand (Orientation) +
Protein Name NITRATE REDUCTASE ALPHA CHAIN
DNA Sequence 
>gi|17988344:987987-990764 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
ATTGCCGCAAATATTCCGACTTCCCGATGCTGGTCATGCTCACGAAGAAGGACGGCCACTACGTGCCGGG
CCCGTTTCGTGCGTGCATCCGACTTCGCCGACAATCTGGGCGAAGGCAACAATCCGGACTGGAAAACGGT
CGGCTTCGACACCAAGTCCGGCGCCTATGTCGCTCCGACAGGGTTCCATCGGCTTCCGCTGGGGCGATGA
TGGCAAGTGGAACCTGGAAGAAAAGGACGGCAAGGGCAAGGATGTGGAACTTGCCAAGAGCTTCATCGAC
AAGGACGCACATGATGCCGTTGCCGATGTGGCCTTCCCTTATTTCGGCAATCTCGACCATGAACATTTCG
AGGGCACCGATCATGACAGCATCCTCGTGCGCAAGGTTCCCGCCCGCACGCTGAAGCTGAAGGAAGGCGA
CGTGATGGTCGCCACTGTCTTCGATCTCTTTGCGGCCAATTACGGTCTCGACCGCGGCCTTGGCGATGAA
AACTGCGCCAAGAGCTATGATGACGGCCTGCCCTACACCCCGGCATGGGCCGAAAAGATCACCGGCGTTC
CGCGCGCCCAGATCATTGCGGTTGCCCGTGAATTTGCGACCAATGCCGAAAAGACCAATGGCCGTTCCAT
GGTCATCGTTGGCGCCGGTCTCAATCACTGGTACCACATGGATATGAACTATCGCGGCATCATCAACATG
CTGGTGATGTGCGGTTGCGTGGGGCAGTCCGGCGGCGGCTGGAGCCATTATGTCGGGCAGGAAAAGCTGC
GCCCGCAGACCGGCTGGACGGCGCTTGCCTTCGCGCTCGACTGGACCCGCCCGCCGCGCCATATGAACTC
GACATCGTTCTTCTATGCGCACACCGACCAGTGGCGCTACGAGACCGTCAAGGTGCAGGATATCCTGTCG
CCGACTGCGCCGGAAGGCAACTGGGACGGCACGATGATGGATTACAATATCCGCGCCGAGCGCATGGGCT
GGCTCCCGTCCGCGCCGCAGCTTCAGGTAAACCCGCTGGAGGTCGCAAAACAGGCGGCTGAATCCGGCAA
GGACGCGAAGGATTTCGTTGCCGGCGCCCTGAAGAACGGCTCGATCACCATGTCCTGCGAGGATCCGGAC
CATGAGGCCAACTGGCCGCGCAACATGTTCGTCTGGCGTTCCAACCTGCTCGGTTCTTCCGGCAAGGGCC
ATGAATATTTCCTGAAACATCTGCTTGGCACGTCGAACGGCCTGCTTGGCAAGGATCTCGGTCAGGAAGG
CGCACAGGAAAGCCGCGAGGCCGTGTGGCACGAACATGCGCCGGAAGGAAAGCTGGACCTTCTGGTCACG
CTCGACTTCCGCATGTCCACCACCTGCGTCTATTCCGATATCGTTCTGCCGACTGCAACCTGGTACGAAA
AGAACGATCTCAACACTTCCGACATGCATCCCTTCATCCATCCGCTGTCGAGTGCAGCCGATCCGGCCTG
GGAAGCGCGCAGCGACTGGGAAATCTTCAAGGGGATTGCCAAGAAGTTCTCCGATGTTGCACCGGAAGTG
CTGGGCGTAGAAAAGGACGTCGTTCTCGTGCCGACCCTGCACGATACGGCAGGCGAGCTGGCACAGCCCA
AGGACGTTCTGGACTGGAAGCGCGGCGAAGTCGAACCGATCCCCGGCAAGACCATGCCATCGGTCGTCGT
CGTCGAACGCGACTATCCGAACCTCTACAAGCGCTACACCTCCGTTGGCCCGCTTCTCGACAAGCTTGGC
AATGGCGGCAAGGGCATTTCGTGGAACACCCAGCATGAGGTCGATCTGCTGGCCAAGCTCAACGGCAAGG
TTGGCGAGCCGGGTACGAGCGAAGGCCGTCCGCGCATCGACACCGATATCGACGCCACGGAAGTCATCCT
GTCGCTGGCACCGGAAACCAACGGTGAAGTGGCCGTGAAGGCATGGGCTGCGCTGTCCAAGTTCACGGGC
CGCGACCACACCCATCTCGCCATTCCGAAGGAAGACGAGAAGATCCGTTACCGCGATATCGTCGCACAGC
CGCGCAAGATCATCTCCTCGCCCACCTGGTCGGGCCTGGAATCGGAAAGCGTGTGCTACAATGCGGGCTA
CACCAACGTTCACGAACTGATCCCGTGGCGCACGCTGACCGGCCGTCAACAGCTCTATCAGGATCACCTG
TGGATGCGCGCATTCGGCGAAGGCTTCTGCGTCTACCGCCCTCCGATCGATACGCGGACCGTCAGCTCGG
CCATTCGCGCCAAGACGGATGGACAGCCGCATCTGGTGCTGAACTTCATCACCCCGCACCAGAAATGGGG
CATCCACTCCACCTATTCGGACAACCTGTTGATGCTCACGCTCAATCGTGGCGGGCCGGTTGTCTGGATA
GCGGAACCGGATGCAGCCAGGGCCGGCATTGCCGATAATGACTGGGTGGAGATCTATAACTCCAACGGCG
CCATCGTGGCCCGTGCCGTAGTTTCGCAGCGCATGAGGGAGGGAACAACCTTCATGTACCACGCACAGGA
AAAGATCGTGAACACGCCGGGCTCGCCCCTGACCGGGCAACGCGGTGGCATTCACAACTCCGTCACCCGC
GTCATCACCAAGCCTACGCACATGATTGGCGGTTATGCCCATCAGGCTTACGGCTTCAACTATTACGGGA
CCGTCGGCTCCAACCGCGACGAATTCGTGGTGGTGCGCAAGCTGGACAAGGTGGACTGGATGGAAGGTCC
GCTCGAAGAAGGCAACAAGTCGTCCCAGGTTAAGGAGGCAGCAGAATG
Protein Sequence 
>gi|17989295|ref|NP_541928.1| nitrate reductase alpha chain [Brucella melitensis bv. 1 str. 16M] MPQIFRLPDAGHAHEEGRPLRAGPVSCVHPTSPTIWAKATIRTGKRSASTPSPAPMSLRQGSIGFRWGDDGKWNLEEKDGKGKDVELAKSFIDKDAHDAVADVAFPYFGNLDHEHFEGTDHDSILVRKVPARTLKLKEGDVMVATVFDLFAANYGLDRGLGDENCAKSYDDGLPYTPAWAEKITGVPRAQIIAVAREFATNAEKTNGRSMVIVGAGLNHWYHMDMNYRGIINMLVMCGCVGQSGGGWSHYVGQEKLRPQTGWTALAFALDWTRPPRHMNSTSFFYAHTDQWRYETVKVQDILSPTAPEGNWDGTMMDYNIRAERMGWLPSAPQLQVNPLEVAKQAAESGKDAKDFVAGALKNGSITMSCEDPDHEANWPRNMFVWRSNLLGSSGKGHEYFLKHLLGTSNGLLGKDLGQEGAQESREAVWHEHAPEGKLDLLVTLDFRMSTTCVYSDIVLPTATWYEKNDLNTSDMHPFIHPLSSAADPAWEARSDWEIFKGIAKKFSDVAPEVLGVEKDVVLVPTLHDTAGELAQPKDVLDWKRGEVEPIPGKTMPSVVVVERDYPNLYKRYTSVGPLLDKLGNGGKGISWNTQHEVDLLAKLNGKVGEPGTSEGRPRIDTDIDATEVILSLAPETNGEVAVKAWAALSKFTGRDHTHLAIPKEDEKIRYRDIVAQPRKIISSPTWSGLESESVCYNAGYTNVHELIPWRTLTGRQQLYQDHLWMRAFGEGFCVYRPPIDTRTVSSAIRAKTDGQPHLVLNFITPHQKWGIHSTYSDNLLMLTLNRGGPVVWIAEPDAARAGIADNDWVEIYNSNGAIVARAVVSQRMREGTTFMYHAQEKIVNTPGSPLTGQRGGIHNSVTRVITKPTHMIGGYAHQAYGFNYYGTVGSNRDEFVVVRKLDKVDWMEGPLEEGNKSSQVKEAAE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The narG gene encodes for an essential component of the dissimilatory nitrate reductase complex. This complex is encoded by the narGHIJ locus, which is present in the B suis genome together with the gene of the nitrite extrusion protein, narK. The narG mutant was unable to produce nitrite from nitrate (Kohler et al., 2002). A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis xx gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG5013C, under C: Energy production and conversion
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].