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cydB from Brucella melitensis bv. 1 str. 16M

Victor ID 1383
Gene Name cydB from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1198531
NCBI Protein GI 17989104
Locus Tag BMEII0759
Protein Accession NP_541737.1
Other Database IDs UniProtKB-ID: Q8YBX7_BRUME
UniRef100: UniRef100_D0B6V5
UniRef90: UniRef90_D0B6V5
UniRef50: UniRef50_P26458
UniParc: UPI00000585E4
EMBL: AE008918
EMBL-CDS: AAL54001.1
RefSeq_NT: NC_003318.1
GenomeReviews: AE008918_GR
KEGG: bme:BMEII0759
NMPDR: fig|224914.1.peg.2819
HOGENOM: HBG413915
OMA: DLTIYNA
ProtClustDB: CLSK898928
BioCyc: BMEL224914:BMEII0759-MONOMER
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 796412
Gene Ending Position 797479
Gene Strand (Orientation) -
Protein Name CYTOCHROME D UBIQUINOL OXIDASE SUBUNIT II
DNA Sequence 
>gi|17988344:796412-797479 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
ATCAGTAAGCGTGGTTGCTCTCATCCTCGATCATGCTCTTGTCCACCTTGCCCCAAAGGACCTTATAGAC
CCATGCGGTATAGGCGACGATGATCGGAATGAAGACGACCGTTACCACCAGCATGATGAACAGCGTCTGA
TGGCTGGACGATGAATCCCAGACCGTCAGGCTCGATTGCGGATCGATCGAAGACGGCAGGATGAACGGAA
ACATCGACACGCCGACAGACGAGATGATGCCGAAGATCGAGAGTTTTCCGAAGAGGAGCGGAGCAAGTTC
ACGACCGCCGCGTAGCGTTGCGAGAACCGCGAGCGCACCGAGAATGCCAAGCGCAGGCGCGATCAGCAGG
ATCGGATAATTCGCATAGTTCGCAAACCAGGCGCCGTGATCCAGTTCCACGGTCTTTTGCAGCGGGTTGG
AAGGCCCGTCCATCACCACCGCACTGGTTATGCGATACCCCGACACCCAAAGCCAGCTTATGGCACCGGC
GACGATGTAGAGAATGACGGTCAACAGCGCCGCAACGCTGCCATAGGCCCGCGCCCGCGCCTGTATCACG
CCATCTGTCTTCAAAACGAGCCATGCCGCGCCATGCATGGTGAGCATGGTGACGGACAGGATGCCGCACA
GAAGCGCAAACGGATTGAGCAGGCCGAAGAATGAGCCTTCGTAGAAGATCTGGAGATCGCCGTTGAGCCG
GAAGGGAACCCCCTGAAGCACATTTCCAACCGCCACGCCGAAGATCAGCGCCGGCACGAAGCCGCCGATG
AACAGCGCCCAGTCCCAACTGTTGCGCCAGGTTTCTCCATCACGCTTGGAGCGGAACTTGAAGCCGACCG
GGCGCAGGATGAGCGCGAACAGGATGACGAACATCGCCAGATAGAACCCGGAGAAGGACACCGCATAAAG
CGGCGGCCAGGCGGCGAAGATCGCACCGCCGCCAAGGATCAACCAGACCTGATTGCCTTCCCAGACGGGG
CCGATTGTATTGATGACGACGCGACGCTCCACATCGGTTCTGGCAACGAAAGGCAGAAGCGTGCCGACGC
CGAGGTCGAAACCATCCA
Protein Sequence 
>gi|17989104|ref|NP_541737.1| cytochrome D ubiquinol oxidase subunit II [Brucella melitensis bv. 1 str. 16M] MDGFDLGVGTLLPFVARTDVERRVVINTIGPVWEGNQVWLILGGGAIFAAWPPLYAVSFSGFYLAMFVILFALILRPVGFKFRSKRDGETWRNSWDWALFIGGFVPALIFGVAVGNVLQGVPFRLNGDLQIFYEGSFFGLLNPFALLCGILSVTMLTMHGAAWLVLKTDGVIQARARAYGSVAALLTVILYIVAGAISWLWVSGYRITSAVVMDGPSNPLQKTVELDHGAWFANYANYPILLIAPALGILGALAVLATLRGGRELAPLLFGKLSIFGIISSVGVSMFPFILPSSIDPQSSLTVWDSSSSHQTLFIMLVVTVVFIPIIVAYTAWVYKVLWGKVDKSMIEDESNHAY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cydB is a gene that is part of the cydAB operon encoding cytochrome bd oxidase , which catalyzes an alternate terminal electron transport step in bacterial respiration. Transposon (Tn5) mutagenesis of B abortus cydB was severely attenuated for intracellular survival. Unlike the virulent strain 2308, the Brucella cydB::Tn5 mutant was severely compromised for survival in the spleens of inoculated mice (Endley et al., 2001). The cydB and cydD mutants are also defective for the intracellular growth of B abortus and B suis, suggesting that functional cytochrome bd oxidase is required for growth in an intracellular environment (Kim et al., 2003).
COG COG1294C, under C: Energy production and conversion
References
Endley et al., 2001: Endley S, McMurray D, Ficht TA. Interruption of the cydB locus in Brucella abortus attenuates intracellular survival and virulence in the mouse model of infection. Journal of bacteriology. 2001; 183(8); 2454-2462. [PubMed: 11274104].
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].