Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

xseA from Brucella melitensis bv. 1 str. 16M

Victor ID 1370
Gene Name xseA from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1198299
NCBI Protein GI 17988872
Locus Tag BMEII0527
Protein Accession NP_541505.1
Other Database IDs UniProtKB-ID: EX7L_BRUME
UniRef100: UniRef100_Q8YCK1
UniRef90: UniRef90_B2SAR1
UniRef50: UniRef50_B6IXD4
UniParc: UPI00001A9603
EMBL: AE008918
EMBL-CDS: AAL53769.1
RefSeq_NT: NC_003318.1
GenomeReviews: AE008918_GR
KEGG: bme:BMEII0527
NMPDR: fig|224914.1.peg.2587
HOGENOM: HBG634411
OMA: LVWPVKV
ProtClustDB: PRK00286
BioCyc: BMEL224914:BMEII0527-MONOMER
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 551876
Gene Ending Position 553417
Gene Strand (Orientation) +
Protein Name exodeoxyribonuclease VII large subunit
DNA Sequence 
>gi|17988344:551876-553417 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
GATGAGCATGGCCTCCGATTCGAGTTTTCCCGGCGCATCGTCGAATGTGGCCGAGTATAGCGTGTCCGAG
ATTTCCGGCGCTTTGAAGCGCACGGTTGAGGACACGTTCGGCCATGTGCGTGTGCGCGGCGAGATTTCCG
GCTATCGCGGCCCGCATTCTTCCGGCCATGCCTATTTTGCGCTGAAGGATGACCGTGCCCGGCTTGAAGC
CGTGATCTGGCGCGGCTCGATGAGCCGCCTTCGCTTCCGCCCCGAAGAGGGCATGGAGGTGATCGCCACC
GGCAAGCTCACCACCTATCCCGGTTCATCCAAATATCAGATCGTCATCGAGCAGATGGAACCCGCCGGCG
CGGGCGCGCTGATGGCGCTTCTGGAGGAGCGCAAGCAGCGCCTGGCGGCAGAAGGCCTGTTCGATCCTGC
CCTGAAACAGCTTCTGCCCTTCATGCCGCGCGTCATCGGCGTGGTGACATCTCCCACCGGCGCGGTCATC
CGCGATATCATCCATCGCATTTCCGATCGTTATCCGCTGCGCGTGATCGTCTGGCCGGTGCGCGTGCAGG
GCGATACCTGCGGGCCTGAAGTGGCAACGGCGGTGAACGGCTTCAACACCCTGCCGGATGACGGCCCCAT
TCCGCGCCCCGATGTGCTGATCGTGGCGCGCGGCGGCGGCAGTCTGGAAGATCTCTGGGGCTTTAACGAT
GAAATCGTCGTGCGGGCGGTCGCAGCTTCCCATATTCCCGTTATCTCGGCGGTCGGGCATGAAACCGACT
GGACGCTGATAGATCTTGCCGCCGACATGCGCGCGCCGACCCCCACCGGTGCTGCGGAAATGGCGGTGCC
GGTGAAGGCTGATCTTCAGGCCTCACTTGCCAGCCAGTCGGCGCGGCTTTCTTCCGCCATGTCGCGCTTT
TTCGACCAGAAGCGACAGGCGCATCGTGCTGCCGCGCGCGCCATGCCCTCTGCCGACCAGTTGCTGGCCC
TGCCGCGCCGCCGGTTCGATGAAGCGGCCTCGCGGCTTACCCGCGCACTTTTCGTCAATACGCAGAAAAA
GCGCGTCCATTTCGATGGTCATGCCCGGCAATTGTCGCCCCGGCTTTTACAGCGGCGGCTTGTGGAGCTG
GAACGCGGTGTGACGATGCTGGGCCAGCGCCTGCCGCGCGCGCTGGAAGCCTTTCTGCGCGAGCGCCGGA
CGGCTTTCACCCATCGCGCCAACCGGCTTTCGCCGGAACCCATATTGCGCCGCACACGGCTGACGGGCTC
GACCCTCGAACAGCTCGACCGCCGCCGCGATCAGGCCGTGCGGCTTCTGATCGAGCGTGTGAAGCGGCGC
AGTCAAGAACTCGACCGGTTGATGCGCACGCTTTCTTATGAAAGCGTGCTGGAACGCGGCTTTGCTGTTG
TATTCGATGCGCAGGGAAAGCCCGTCAAGCAGGCGGCGGCTGTGTCGCCAGGCGATGCGCTGTCTGTCCG
GTTCCGCGACGGTGATGTCGGGGTTGTCGCGCGCGCGGGGCTCACAATCCCCGATCCGACCAAAGGCCAG
TA
Protein Sequence 
>gi|17988872|ref|NP_541505.1| exodeoxyribonuclease VII large subunit [Brucella melitensis bv. 1 str. 16M] MSMASDSSFPGASSNVAEYSVSEISGALKRTVEDTFGHVRVRGEISGYRGPHSSGHAYFALKDDRARLEAVIWRGSMSRLRFRPEEGMEVIATGKLTTYPGSSKYQIVIEQMEPAGAGALMALLEERKQRLAAEGLFDPALKQLLPFMPRVIGVVTSPTGAVIRDIIHRISDRYPLRVIVWPVRVQGDTCGPEVATAVNGFNTLPDDGPIPRPDVLIVARGGGSLEDLWGFNDEIVVRAVAASHIPVISAVGHETDWTLIDLAADMRAPTPTGAAEMAVPVKADLQASLASQSARLSSAMSRFFDQKRQAHRAAARAMPSADQLLALPRRRFDEAASRLTRALFVNTQKKRVHFDGHARQLSPRLLQRRLVELERGVTMLGQRLPRALEAFLRERRTAFTHRANRLSPEPILRRTRLTGSTLEQLDRRRDQAVRLLIERVKRRSQELDRLMRTLSYESVLERGFAVVFDAQGKPVKQAAAVSPGDALSVRFRDGDVGVVARAGLTIPDPTKGQ
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)(UniProt: Q8FVR1).

CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates(UniProt: Q8FVR1).

SUBUNIT: Heterooligomer composed of large and small subunits (By similarity)(UniProt: Q8FVR1).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8FVR1).

SIMILARITY: Belongs to the xseA family(UniProt: Q8FVR1).

MUTATION: xseA codes for an exodeoxyribonuclease. B. melitensis xseA mutant via signature-tagged mutagenesis is attenuated in vivo in mice (Lestrate et al., 2003).
COG COG1570L, under L: Replication, recombination and repair
References
Lestrate et al., 2003: Lestrate P, Dricot A, Delrue RM, Lambert C, Martinelli V, De Bolle X, Letesson JJ, Tibor A. Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice. Infection and immunity. 2003; 71(12); 7053-7060. [PubMed: 14638795].