Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

ftcR

Victor ID 1350
Gene Name ftcR
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197929
NCBI Protein GI 17988502
Locus Tag BMEII0158
Genbank Accession NZ_GG703779
Protein Accession NP_541135
Other Database IDs UniProtKB-ID: D0B5E8_BRUME
UniRef100: UniRef100_Q2YJF8
UniRef90: UniRef90_Q2YJF8
UniRef50: UniRef50_Q2YJF8
UniParc: UPI000005838D
EMBL: GG703779
EMBL-CDS: EEW86840.1
RefSeq_NT: NC_003318.1
OMA: WANILIR
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 170441
Gene Ending Position 171124
Gene Strand (Orientation) +
Protein Name two component response regulator
Protein pI 6.15
Protein Weight 23952.3
Protein Length 227
DNA Sequence 
>gi|17988344:170441-171124 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
GATGATTGTTGTCGTTGACGACAGAGACATGGTGACTGAAGGATATTCTTCCTGGTTCGGTCGCGAAGGG
ATCACGACAACAGGTTTCACACCTACCGATTTCGATGAATGGGTCGAGAGTGTTCCTGAACAGGATATTA
TGGCGATTGAAGCCTTCCTGATTGGTGAATGCGCCGACCAGCATCGCCTCCCGGCCCGCATTCGTGAACG
CTGCAAGGCGCCTGTTATCGCCGTCAACGACCGTCCTTCGCTTGAGCATACACTTGAGCTTTTTCAATCC
GGGGTTGACGATGTGGTGCGCAAGCCCGTTCATGTCCGCGAAATTCTCGCGCGCATCAATGCGATCCGCC
GCCGTGCGGGCGCATCGGCAACCTCTGGCGCAGATGGCACGCAACTGGGGCCGATCCGTGTTTTCTCCGA
TGGCCGCGATCCGCAGATCAACGGTATCGATTTTCCGCTCCCGCGCCGTGAGCGCCGCATTCTGGAATAT
CTGATTGCCAATCGCGGCCGTCGTCTCAACAAGGTGCAGATTTTTAGTGCGATTTACGGCATTTTCGACA
GTGAAGTCGAAGAAAATGTCGTTGAAAGCCATATCAGCAAATTGCGCAAGAAATTGCGCGGACAGCTTGG
GTTCGATCCTATCGATTCCAAGCGTTTCCTGGGCTACTGCATCAATATCGAGTG
Protein Sequence 
>gi|17988502|ref|NP_541135.1| two component response regulator [Brucella melitensis bv. 1 str. 16M]
MIVVVDDRDMVTEGYSSWFGREGITTTGFTPTDFDEWVESVPEQDIMAIEAFLIGECADQHRLPARIRER
CKAPVIAVNDRPSLEHTLELFQSGVDDVVRKPVHVREILARINAIRRRAGASATSGADGTQLGPIRVFSD
GRDPQINGIDFPLPRRERRILEYLIANRGRRLNKVQIFSAIYGIFDSEVEENVVESHISKLRKKLRGQLG
FDPIDSKRFLGYCINIE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: FtcR is required in B melitensis 16M for the transcription of the fliF gene during vegetative and intracellular growth, and for the production of the two structural flagellar components FlgE and FliC during vegetative growth. A ftcR mutant has the same virulence phenotype as previously found with structural flagellar mutants. In HeLa cells and bovine macrophages, no attenuation of the ftcR mutant was observed compared to the WT parental strain. In BALB/c mice, the ftcR mutant was not attenuated after 1 week of infection but was attenuated after 4 weeks of infection. FtcR acts as a flagellar master regulator in B melitensis and perhaps in other related alpha-proteobacteria (Léonard et al., 2007).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Léonard et al., 2007: Léonard S, Ferooz J, Haine V, Danese I, Fretin D, Tibor A, de Walque S, De Bolle X, Letesson JJ. FtcR is a new master regulator of the flagellar system of Brucella melitensis 16M with homologs in Rhizobiaceae. Journal of bacteriology. 2007; 189(1); 131-141. [PubMed: 17056750].