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fliF from Brucella melitensis bv. 1 str. 16M

Victor ID 1348
Gene Name fliF from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197922
NCBI Protein GI 17988495
Locus Tag BMEII0151
Protein Accession NP_541128.1
Other Database IDs UniProtKB-ID: FLIF_BRUME
UniRef100: UniRef100_Q8YDM4
UniRef90: UniRef90_O52069
UniRef50: UniRef50_O52069
UniParc: UPI0000EADFB4
EMBL: AE008918
EMBL-CDS: AAL53392.1
EMBL-CDS: AAL53393.1
RefSeq_NT: NC_003318.1
OMA: RTIQSIS
BioCyc: BMEL224914:BMEII0151-MONOMER
BioCyc: BMEL224914:BMEII0152-MONOMER
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 163505
Gene Ending Position 164233
Gene Strand (Orientation) +
Protein Name FLAGELLAR M-RING PROTEIN FLIF
DNA Sequence 
>gi|17988344:163505-164233 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
GATGGCGGTGGTGTGGATGCAGCAGAATTTCCAGCAATTGATCGAACAGCTCAAGGGAACGCTCGGCAAG
CTTGGTGCGCGAAAGCTCATCGCGCTCGGCCTTGTAGGCGCGGCTTTGATGGGTGCGATCCTCTATACGA
GCATCTATCTGGGTCGCCCATCCTACGAGACGCTCTATGTCGGCCTTTCGCGCGATGACGTGAACCGCAT
GGGCCTTGCGCTCGGTGAAGCTGGCATTCCCTTCGACGTGAAGTCTGATGGATCCTCGATCCTCGTTCCA
ATCGGCAAGGCCGAAAACGCCCGCATGTATCTGGCCGAAAAGGGCCTGCCGACCTCGAACAATGCCGGTT
ATGAGCTGTTCGACAATATGGGGTCGCTGGGGCTTACGTCCTTTATGCAGGAGATTACCCGTGTGCGCGC
GCTCGAAGGAGAAATTGCCCGTACCATTCAGGCCATTCGCGGCGTGAAGGCTGCGCGCGTTCACATCGTT
CTGGCCGAAAAAGGCTCGTTCCGCCGCGGCGACCAGAAGCCGTCTGCCTCGGTCGTTATTCGTGCCGAAG
GCGGATTTTCCGCTGAATCGGCCCAGTCCATCCGCCAGCTGGTCGCCGCTGCCGTTCCCTCGCTCGATGC
GTCTTCCGTCACGGTGCTCGATACAAATGGCCATCTGCTGGCATCGGCTGGCGAAGGGGCCAATGGTGCG
GCTCTCATGACCGCGTCGCTTGAACAGTA
Protein Sequence 
>gi|17988495|ref|NP_541128.1| flagellar M-ring protein FLIF, partial [Brucella melitensis bv. 1 str. 16M] MAVVWMQQNFQQLIEQLKGTLGKLGARKLIALGLVGAALMGAILYTSIYLGRPSYETLYVGLSRDDVNRMGLALGEAGIPFDVKSDGSSILVPIGKAENARMYLAEKGLPTSNNAGYELFDNMGSLGLTSFMQEITRVRALEGEIARTIQAIRGVKAARVHIVLAEKGSFRRGDQKPSASVVIRAEGGFSAESAQSIRQLVAAAVPSLDASSVTVLDTNGHLLASAGEGANGAALMTASLEQ
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: The M ring may be actively involved in energy transduction (By similarity)(UniProt: Q8FUS3).

SUBUNIT: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity)(UniProt: Q8FUS3).

SUBCELLULAR LOCATION: Inner membrane; multi-pass membrane protein (By similarity)(UniProt: Q8FUS3).

SIMILARITY: Belongs to the fliF family(UniProt: Q8FUS3).

MUTATION: fliF is a gene potentially coding for the MS ring, a basal component of the flagellar system. Its mutant through signature- tagged mutagenesis is attenuated in vivo. It implicate a role for flagella in virulenc (Lestrate et al., 2003).
COG COG1766NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Lestrate et al., 2003: Lestrate P, Dricot A, Delrue RM, Lambert C, Martinelli V, De Bolle X, Letesson JJ, Tibor A. Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice. Infection and immunity. 2003; 71(12); 7053-7060. [PubMed: 14638795].