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dhbC

Victor ID 1342
Gene Name dhbC
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197848
NCBI Protein GI 17988421
Locus Tag BMEII0077
Genbank Accession AE008918
Protein Accession NP_541054
Other Database IDs UniProtKB-ID: Q8YDU7_BRUME
UniRef100: UniRef100_Q8YDU7
UniRef90: UniRef90_Q9EZ80
UniRef50: UniRef50_E1V3P0
UniParc: UPI000005833C
EMBL: AE008918
EMBL-CDS: AAL53318.1
RefSeq_NT: NC_003318.1
GenomeReviews: AE008918_GR
KEGG: bme:BMEII0077
NMPDR: fig|224914.1.peg.2136
HOGENOM: HBG405459
OMA: VTIRCAR
ProtClustDB: CLSK898676
BioCyc: BMEL224914:BMEII0077-MONOMER
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 77032
Gene Ending Position 78288
Gene Strand (Orientation) +
Protein Name isochorismate synthase
Protein pI 7.1
Protein Weight 43028.62
Protein Length 418
Protein Note synthesizes isochorismate acid from chorismate
DNA Sequence 
>gi|17988344:77032-78288 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
ATTGGGACCAATTAAATCAAGTATAAAACGTGACTGGTTCTTTCAAGTATTAATTTCGGCAACGACGCCA
AGGAGACTCCCCGTGAGAACGAGCGCCCTGAAATACCCAACTTCAGACGCAGACCATCTTATTGAAAATA
ATACTGATTTCTCGTTTGCATCCGGCAATCTGAAACTGGCGGCCAGCGGCATGCGTAAGGTGATCGCGAC
GCCTGCCATTGGCGGCAGCAACCCCGACAGCACCTTCCAGCGGGCAATTGCGCAGGCTTTCGAGCGCGCC
GCACGCGCTGGGCAGCGCAATCCGATCGTGGTGGGTGCAATCCCGTTCGACCCCGGCGAACCCTCCTGTC
TCTATGTGCCCGAGGAGATGGACTGGCAGGAGCGGGAGCCAGCCAGCGGGGCGAGCGCCGCCGCCATGCC
GCAACTGGCGGGGCAGAGAAGCGTACCGGACGAAGCGGGTTTCAAGCACGCGGTAGAACATGCCATCATC
AATTTTCGCCTTAGCGACGTGCGCAAGGCGGTGCTTTCGGTGATGCGCGAACTCACTTTCGCGGACGATA
TCGATGTCGACGCCATGCTGGCCAATCTGCGCGCGCAAAACCATGACGGCTATCAGTTTCGCGTGCCTTT
GCCCGGTGGCGGCGCATTGGTCGGTGTCAGCCCGGAACTCCTGATCCACAAGGACAAGGGAAAGATCGTA
TCCAACCCTCTGGCCGGATCGGCGAAGCGCATGGCCGACCCGGAGGCGGACAGGAAAAATGCCGATCGCC
TGGCCAAATCCGAAAAGGACCATTACGAACATCGCCTGGTGATCGAGGATATCAGAGCACGGCTTCAGCC
CATCTGCACGGAACTGGACATACCGGAACGGCCGTCGCTCATCCACACGGCAGCACTCTGGCATCTTTCG
ACCCGCATCGAGGGCCGGCTGCATGATCCCGATATGACAGCCTTGCAGCTTGCCTGCCTCATCCACCCGA
CGCCTGCCGTCTGCGGTTTCCCGACCGAGCGCGCGCGCCGCCTGATCCGCTTTGTAGAACCTTTCGAGCG
TGGATTGTTTACCGGCATGGTCGGCTGGAGCGACGCGGAAGGCAATGGCGAATGGGTCGTCACCATCCGT
TGCGGCACGGTGAAGGGCAATCTTGTGCGCCTCTTTGCCGGGGCGGGGATCGTGGAAGCCTCCAGCCCGG
ATTCCGAATGGGCCGAAGTACAGACCAAGCTTGGCACCATGCTGCGTGCCTGCGGCCTTTCGGCCTG
Protein Sequence 
>gi|17988421|ref|NP_541054.1| isochorismate synthase [Brucella melitensis bv. 1 str. 16M]
MGPIKSSIKRDWFFQVLISATTPRRLPVRTSALKYPTSDADHLIENNTDFSFASGNLKLAASGMRKVIAT
PAIGGSNPDSTFQRAIAQAFERAARAGQRNPIVVGAIPFDPGEPSCLYVPEEMDWQEREPASGASAAAMP
QLAGQRSVPDEAGFKHAVEHAIINFRLSDVRKAVLSVMRELTFADDIDVDAMLANLRAQNHDGYQFRVPL
PGGGALVGVSPELLIHKDKGKIVSNPLAGSAKRMADPEADRKNADRLAKSEKDHYEHRLVIEDIRARLQP
ICTELDIPERPSLIHTAALWHLSTRIEGRLHDPDMTALQLACLIHPTPAVCGFPTERARRLIRFVEPFER
GLFTGMVGWSDAEGNGEWVVTIRCGTVKGNLVRLFAGAGIVEASSPDSEWAEVQTKLGTMLRACGLSA
Molecule Role Virulence factor
Molecule Role Annotation FUNCTIONAL GROUP: Metal acquisition (Delrue et al., 2004).

FUNCTION: Sideophore sysnhesis, Fe3+ uptake (Delrue et al., 2004).

MUTATION: Attenuated in Pregant goat, but not in Mice, IFN-/-Mice, Macrophages, Trophoblastes (Delrue et al., 2004).
COG COG1169HQ, under H: Coenzyme transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism
References
Delrue et al., 2004: Delrue RM, Lestrate P, Tibor A, Letesson JJ, De Bolle X. Brucella pathogenesis, genes identified from random large-scale screens. FEMS microbiology letters. 2004; 231(1); 1-12. [PubMed: 14979322].