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gltD from Brucella melitensis bv. 1 str. 16M

Victor ID 1339
Gene Name gltD from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197811
NCBI Protein GI 17988384
Locus Tag BMEII0040
Protein Accession NP_541017.1
Other Database IDs UniProtKB-ID: Q8YDY4_BRUME
UniRef100: UniRef100_Q8YDY4
UniRef90: UniRef90_B2SCM2
UniRef50: UniRef50_B2SCM2
UniParc: UPI0000058317
EMBL: AE008918
EMBL-CDS: AAL53281.1
RefSeq_NT: NC_003318.1
HSSP: P55038
GenomeReviews: AE008918_GR
KEGG: bme:BMEII0040
NMPDR: fig|224914.1.peg.2099
HOGENOM: HBG313993
OMA: WMAARQA
ProtClustDB: CLSK2299055
BioCyc: BMEL224914:BMEII0040-MONOMER
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 40540
Gene Ending Position 45261
Gene Strand (Orientation) -
Protein Name GLUTAMATE SYNTHASE [NADPH] LARGE CHAIN
DNA Sequence 
>gi|17988344:40540-45261 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
CTTACTCAGCCGCCACGCCGATCTGCATGCGCTCCATCTCTTCCAGAGCGCGGCGATATTCCACCGGCAT
GACCTTCACGAATTTCGGGCGATAGCTTTCCCAATTGTCGAGAATGTCTTTTGCGCGCGTCGAACCCGTA
TAGTGCAGGTGGTTGGCGATTAGCTGCACCAGACGCTCCTCATCATGATGGGTCATGTTGGCGGAAACGT
CCACACGGCCCTTGTGCATGAGATCGCCGCCATGGTGATGCAGCTTTTCCAGAATGTCGTCTTCTTCCGG
CACCGGCTCCAGCTCGACCATCGCCATGTTGCAACGCTGCGCGAAATCGCCTTCCTCATCAAGCACATAG
GCGACGCCGCCCGACATGCCCGCCGCGAAATTGCGCCCCGTCTGCCCGATCACGACAACCACGCCGCCGG
TCATATATTCGCAGCCGTGGTCGCCCACACCTTCGACAACCGTAACCGCACCGGAGTTGCGCACGGCGAA
ACGCTCGCCCGCAACGCCGCGGAAATAGCACTCGCCTTCAAGCGCGCCGTAGAGCACCGTATTGCCGACG
ATGATCGAATCCTCGGCGACGATGCGCGTGTCTTCCGGCGGGCGCACCACGATGCGGCCACCTGAAAGGC
CCTTGCCGATATAATCATTGCCGTCACCGATCAGTTCAAACGAGATGCCGCGTGCGAGGAAGGCACCGAA
GGACTGGCCAGCCGTACCGCGAAGCGTGACGGAGATGGTGTCTTCCGGCAGGCCCTTGTGGCGGAAACGC
TTGGCCACTTCGCCCGAGAGCATTGCGCCTGCGGAACGATCCACATTCTTGATCTCCACGTCGATCTTGA
CCGGCTGGCGTTCTTCGAGCGCAGGCGCGGCCAATTCGATCAGCTTGCGATCCAGAATATCGTCGATCGG
GTGGTGCTGGCGCTCGGTCCAGTAGATTTCGTGCTTCTCGGCCTCCGGCTTGTAGAAGATGCGGCTGAAA
TCCAGCCCTTTCGCCTTCCAGTGGTCGATCATCGCCTGCTTTTCCAGAAGCTCGGTTTCACCGATGATCT
GTTCCAGCCGGGTGAAACCCATCTGGGCCAAAAGCGCGCGCACTTCTTCCGCCAGATAGAAGAAGAAGTT
GATGACGTGTTCCGGCGTGCCCTTGAAACGCTTGCGTAAGACGGGATCCTGCGTCGCCACGCCGACGGGG
CAGGTGTTCAGATGGCACTTGCGCATCATGATGCAGCCAGCCGCAATCAGCGGAGCGGTCGAGAAACCGA
ACTCGTCAGCCCCGAGCAGCGCGCCGATGACCACGTCGCGCCCGGTGCGCAAGCCGCCATCGACCTGAAG
CGCCACGCGGGAGCGAAGCCCGTTCAGCACCAGCGTCTGGTGGGTTTCGGCAAGGCCGATTTCCCACGGG
GAACCGGCGTGCTTCAGCGAGGTGAGCGGTGAAGCGCCCGTGCCGCCATCATAGCCCGACACGGTGATAT
GGTCGGCGCGCGCCTTGGCGACACCGGCTGCAACCGTGCCCACGCCCACTTCCGACACCAGCTTGACCGA
AATATCGGCTGCCGGATTGACGTTTTTCAGGTCGTAGATGAGCTGCGCCAGATCTTCAATCGAGTAGATG
TCATGGTGCGGCGGCGGCGAAATGAGGCCAACACCCGGCGTGGAGTGGCGGGTCTTGGCGATGGTCGCAT
CGACCTTGTGCCCCGGAAGCTGGCCGCCTTCGCCGGGCTTTGCGCCCTGCGCAACCTTGATCTGGATCAG
ATCGGAATTGACGAGATATTCCGTCGTCACACCGAAACGGCCCGAGGCCACCTGCTTGATTGCCGAGCGT
TCCGGGTTCGCCGTGCCATCCGGCAGCGGGTAGAAACGATCCGGCTCCTCGCCGCCCTCGCCGGTGTTCG
ACTTGCCGCCAATGGCGTTCATCGCGCGGGCAAGCGTGGTATGCGCCTCTCTGGAGATCGAGCCGAAGGA
CATGGCGCCGGTTGAGAACCGCTTGACGATATCCGTTGCCGGCTCCACCTCATCGATGGAAACGGGCTTC
AGGCCACGTTCCTCGGCAAAGCGGATATTGAACAGGCCGCGAATGGTCTTGGCCTGCGACGACTTGGCGT
CGAGCATCCTCGTATATTCGGTGAACGTGTCTGGATTGGACGTGCGCACCGCATGTTGCAGCTTTGCCAC
CGCATCCGGCGACCACATATGCGCCTCGCCGCGCATACGATAGGCATATTCGCCGCCGACTTCGAGCGCG
TTCAGAAGAACGGGATCATTGCCGAAAGCATCGGTGTGACGGCGCACGGTTTCTTCCGCGATCTCGTCGA
GGCCAACGCCTTCGATGGTCGTGGCGGTGCCGAAGAAGAACTTGTCCACGAAATCCGTCCTGACGCCGAC
CGCATCGAAAATCTGCGCGCCGCAATAGGACTGATAGGTCGAGATACCCATCTTGGACATGACCTTGAGG
ATGCCCTTGCCAATCGACTTGATGTAGCGCTTGACCACTTCATGCTCGTCGACTTCCGGCGGAAATTCGC
GGCGGCGATGCATGTCGAGCAGCGTGTCGAAGGCGAGATAGGGATTGATCGCTTCGGCGCCATAGCCTGC
GAGGCAGGCAAAATGATGCACTTCGCGCGGCTCGCCCGATTCCACCACAAGACCGACCGAGGTGCGAAGA
CCCTTGCGGATCAGGTGATGGTGCACGGCAGCCGTCGCCAGCAGGGCCGGGATCGGAATACGGTCCGGCC
CGACCTGGCGGTCGGAGAGGATGACGATGTTATAGCCGCCATGAACGGCTGCTTCCGCGCGGTCGCACAG
ACGCTCGATGGCGCCATGCATACCGGTCGCGCCCTCGCCCGTATTATAGGTGATGTCGAGCGTCTTGGTA
TCGAAGCGGTCTTCCGTGTGGCCGATAGAACGGATCTTTTCCAGATCGCCATTGGTCAGGATGGGCTGGC
GCACTTCCAGACGCTTGCGGCGCGAGGCGCCGACAAGATCGAAGATGTTTGGACGCGGGCCAATGAAGGA
GACGAGGCTCATCACCAGTTCCTCGCGGATCGGATCGATCGGCGGGTTCGTCACCTGTGCGAAGTTCTGC
TTGAAATAGGTGTAAAGCAGCTTCGACTTGTCGGACATGGCCGAAATTGGCGTATCGGTGCCCATGGAGC
CGATGGCTTCCTGACCCGTGGTCGCCATCGGCGCCATCAGGAACTTGGTATCTTCCTGCGTATAGCCGAA
GGCCTGCTGGCGGTCGAGCAGGCTCACATCCTTGCGCAGCGCACGCGGCTCGACCGGGTTGAGGTCTTCC
AGAATGAGCTGCGTATTGGCAAGCCACTGCTTGTAAGGGTGCTTCTGCGCGATCTGCGACTTGATTTCCT
CATCGGAGATGATGCGGCCTTCTTCCATGTCGATCAGCAGCATGCGGCCCGGCTGAAGACGCCACTTCCT
GACGATCTTTTTTTCATCGACCGGCAGGACGCCTGCTTCCGAAGCCAGAATGACGAAATCGTCTTCCGTC
ACGATATAGCGTGCAGGCCGCAGGCCGTTGCGGTCCAGCATCGCGCCGATCTGGCGGCCATCGGTGAAGG
CGACAGCGGCAGGGCCATCCCACGGCTCCATGAGTGCTGCATGATATTCGTAGAACGCGCGGCGCTCATC
CGACATCAGCTTGTTGCCCGACCATGCTTCCGGGATCAGCATCATCATGGCATGTGCAAGGCTGTAGCCG
CCCTGATGCAGGAATTCGAGCGCATTGTCGAAACAGGCCGTATCCGACTGGCCCTCATAGGAAATTGGCC
AGAGCTTGGAAATATCGTTGCCGAACAGTTCGCTATCGACCGAAGCCTGGCGCGCCGCCATCCGGTTGAC
ATTGCCGCGCAGCGTGTTGATTTCGCCGTTATGGGCGACCATGCGGTAGGGGTGGGCAAGACGCCAGGAC
GGAAAGGTGTTGGTGGAAAAACGCTGGTGCACCAGCGCCACCGCGCTTTCAAAGCGGGGGTCTTTCAAGT
CCAGATAATAAGCGCCGACCTGATAGGCCAGGAACATGCCCTTATAGACCACCGTGCGGGCCGACATGGA
CACGACATAGAAACCCTTATCGTCGCCGTCATTCTCCTGATAGATGCGGTTGGAGATGACCTTGCGCAGC
ACGAACAGGCGGCGCTCGAAATCGTCGTCGGTTTCCAGCATCGGGCTGCGCCCGATGAAGACCTGCATAT
GGAACGGCTCGGTGGCCGCGATATGCGGAGCCTTGGAAAGCGAAGAATTATCGACCGGCACTTCGCGGAA
GCCGATGAAGGTCTGGCCTTCGGCGGCGATCACTTCCCTGACGATCTCTTCCGCATGGGCGCGCAGATCC
GGGTCGCGCGGCATGAAAATATAGCCGACGCCATAGTGACCCGGCTGCGGCAGGTCTATGCCCTGACGCG
CCATTTCCTCGCGAAAGAAGCGATCTGGAATCTGCACCAGAATGCCCGCACCGTCGCCCATCAGCGGATC
GGCGCCGACAGCACCACGATGGGTGAGGTTTTCCAGCATCTTCAGGCCGTTTTCCACGACCACATGTGAT
TTCCTGCCCTTCATATGGGCGATGAAGCCGACGCCGCACGCATCATGCTCGTTGCGCGGATCATAAAGGC
CTTGAGCCGGCGGAACACCCGCAGCCTTGGTTTTTCGCGTCGTTCGGGTGGAAGCCGTCGTCGCAGCTTT
GACCGCTTCGTTCTGTACGTTGTGAGAAACCA
Protein Sequence 
>gi|17988384|ref|NP_541017.1| glutamate synthase [NADPH] large chain [Brucella melitensis bv. 1 str. 16M] MVSHNVQNEAVKAATTASTRTTRKTKAAGVPPAQGLYDPRNEHDACGVGFIAHMKGRKSHVVVENGLKMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMARQGIDLPQPGHYGVGYIFMPRDPDLRAHAEEIVREVIAAEGQTFIGFREVPVDNSSLSKAPHIAATEPFHMQVFIGRSPMLETDDDFERRLFVLRKVISNRIYQENDGDDKGFYVVSMSARTVVYKGMFLAYQVGAYYLDLKDPRFESAVALVHQRFSTNTFPSWRLAHPYRMVAHNGEINTLRGNVNRMAARQASVDSELFGNDISKLWPISYEGQSDTACFDNALEFLHQGGYSLAHAMMMLIPEAWSGNKLMSDERRAFYEYHAALMEPWDGPAAVAFTDGRQIGAMLDRNGLRPARYIVTEDDFVILASEAGVLPVDEKKIVRKWRLQPGRMLLIDMEEGRIISDEEIKSQIAQKHPYKQWLANTQLILEDLNPVEPRALRKDVSLLDRQQAFGYTQEDTKFLMAPMATTGQEAIGSMGTDTPISAMSDKSKLLYTYFKQNFAQVTNPPIDPIREELVMSLVSFIGPRPNIFDLVGASRRKRLEVRQPILTNGDLEKIRSIGHTEDRFDTKTLDITYNTGEGATGMHGAIERLCDRAEAAVHGGYNIVILSDRQVGPDRIPIPALLATAAVHHHLIRKGLRTSVGLVVESGEPREVHHFACLAGYGAEAINPYLAFDTLLDMHRRREFPPEVDEHEVVKRYIKSIGKGILKVMSKMGISTYQSYCGAQIFDAVGVRTDFVDKFFFGTATTIEGVGLDEIAEETVRRHTDAFGNDPVLLNALEVGGEYAYRMRGEAHMWSPDAVAKLQHAVRTSNPDTFTEYTRMLDAKSSQAKTIRGLFNIRFAEERGLKPVSIDEVEPATDIVKRFSTGAMSFGSISREAHTTLARAMNAIGGKSNTGEGGEEPDRFYPLPDGTANPERSAIKQVASGRFGVTTEYLVNSDLIQIKVAQGAKPGEGGQLPGHKVDATIAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVNPAADISVKLVSEVGVGTVAAGVAKARADHITVSGYDGGTGASPLTSLKHAGSPWEIGLAETHQTLVLNGLRSRVALQVDGGLRTGRDVVIGALLGADEFGFSTAPLIAAGCIMMRKCHLNTCPVGVATQDPVLRKRFKGTPEHVINFFFYLAEEVRALLAQMGFTRLEQIIGETELLEKQAMIDHWKAKGLDFSRIFYKPEAEKHEIYWTERQHHPIDDILDRKLIELAAPALEERQPVKIDVEIKNVDRSAGAMLSGEVAKRFRHKGLPEDTISVTLRGTAGQSFGAFLARGISFELIGDGNDYIGKGLSGGRIVVRPPEDTRIVAEDSIIVGNTVLYGALEGECYFRGVAGERFAVRNSGAVTVVEGVGDHGCEYMTGGVVVVIGQTGRNFAAGMSGGVAYVLDEEGDFAQRCNMAMVELEPVPEEDDILEKLHHHGGDLMHKGRVDVSANMTHHDEERLVQLIANHLHYTGSTRAKDILDNWESYRPKFVKVMPVEYRRALEEMERMQIGVAAE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gltD encodes the small subunit of glutamate synthase. It is required for B. abortus growth as shown in signature-tagged transposon mutagenesis. It suggests that glutamate may serve as carbon and/or nitrogen sources during growth of B abortus (Hong et al., 2000).
COG COG0069E, under E: Amino acid transport and metabolism
References
Hong et al., 2000: Hong PC, Tsolis RM, Ficht TA. Identification of genes required for chronic persistence of Brucella abortus in mice. Infection and immunity. 2000; 68(7); 4102-4107. [PubMed: 10858227].