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virB8 from Brucella melitensis bv. 1 str. 16M

Victor ID 1334
Gene Name virB8 from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197803
NCBI Protein GI 17988376
Locus Tag BMEII0032
Protein Accession NP_541009.1
Other Database IDs UniProtKB-ID: D0B5R4_BRUME
UniRef100: UniRef100_Q2YJ78
UniRef90: UniRef90_Q2YJ78
UniRef50: UniRef50_Q2YJ78
UniParc: UPI000005830F
EMBL: GG703779
EMBL-CDS: EEW86956.1
RefSeq_NT: NC_003318.1
OMA: LEMSDES
Taxonomy ID 224914
Chromosome No II
Gene Starting Position 31477
Gene Ending Position 32196
Gene Strand (Orientation) +
Protein Name VirB8
DNA Sequence 
>gi|17988344:31477-32196 Brucella melitensis bv. 1 str. 16M chromosome chromosome II, complete sequence
CATGTTTGGACGCAAACAATCTCCACAGAAATCAGTAAAGAACGGGCAGGGCAATGCGCCTTCGGTATAT
GACGAAGCGTTGAACTGGGAGGCCGCGCACGTCCGGCTGGTCGAAAAATCCGAACGCCGCGCGTGGAAAA
TCGCCGGGGCTTTCGGCACCATTACCGTGCTGCTCGGGATCGGCATCGCCGGGATGTTACCGCTAAAGCA
ACATGTGCCCTACCTGGTGCGCGTCAACGCACAGACAGGTGCGCCTGATATCCTGACCTCGCTCGACGAG
AAGAGTGTCAGCTACGACACTGTAATGGATAAATACTGGCTCTCGCAGTACGTGATAGCGCGTGAAACCT
ACGACTGGTACACGCTGCAAAAGGACTACGAAACCGTAGGCATGTTGTCGTCGCCGTCCGAAGGGCAGAG
CTATGCAAGCCAGTTCCAGGGCGATAAGGCGCTTGACAAGCAATATGGCTCAAATGTGCGCACATCGGTA
ACGATCGTAAGCATCGTGCCGAACGGCAAGGGCATCGGCACGGTGCGCTTTGCGAAGACGACAAAGCGCA
CCAACGAGACCGGTGATGGCGAAACAACGCACTGGATCGCCACCATTGGCTACCAATACGTCAATCCCTC
TTTGATGTCGGAATCGGCCCGCCTGACAAACCCGCTGGGTTTCAATGTCACGAGCTATCGCGTTGATCCA
GAAATGGGAGTGGTGCAATG
Protein Sequence 
>gi|17988376|ref|NP_541009.1| VirB8 [Brucella melitensis bv. 1 str. 16M] MFGRKQSPQKSVKNGQGNAPSVYDEALNWEAAHVRLVEKSERRAWKIAGAFGTITVLLGIGIAGMLPLKQHVPYLVRVNAQTGAPDILTSLDEKSVSYDTVMDKYWLSQYVIARETYDWYTLQKDYETVGMLSSPSEGQSYASQFQGDKALDKQYGSNVRTSVTIVSIVPNGKGIGTVRFAKTTKRTNETGDGETTHWIATIGYQYVNPSLMSESARLTNPLGFNVTSYRVDPEMGVVQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virB8 mutant was attenuated by a mini-Tn5 transposon mutagenesis (Foulongne et al., 2000). Attenuated non-polar virB2, virB4, virB8, virB9 and virB10 Brucella mutants are capable of penetrating cells as the same rate as the virulent wild-type Brucella, transit through EEA1-positive early compartments and then localize in LAMP1-positive compartments at early times of infection (Gorvel and Moreno, 2002).
COG COG3736U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].
Gorvel and Moreno, 2002: Gorvel JP, Moreno E. Brucella intracellular life: from invasion to intracellular replication. Veterinary microbiology. 2002; 90(1-4); 281-297. [PubMed: 12414149].