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pgm from Brucella melitensis bv. 1 str. 16M

Victor ID 1317
Gene Name pgm from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197597
NCBI Protein GI 17988169
Locus Tag BMEI1886
Protein Accession NP_540803.1
Other Database IDs UniProtKB-ID: Q8YEJ2_BRUME
UniRef100: UniRef100_D0B4C2
UniRef90: UniRef90_B2S7V9
UniRef50: UniRef50_C5DGF0
UniParc: UPI0000058241
EMBL: AE008917
EMBL-CDS: AAL53067.1
RefSeq_NT: NC_003317.1
HSSP: P00949
GenomeReviews: AE008917_GR
KEGG: bme:BMEI1886
NMPDR: fig|224914.1.peg.1885
HOGENOM: HBG286308
OMA: HDQKPGT
ProtClustDB: PRK07564
BioCyc: BMEL224914:BMEI1886-MONOMER
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1936858
Gene Ending Position 1938558
Gene Strand (Orientation) +
Protein Name phosphoglucomutase
DNA Sequence 
>gi|17986284:1936858-1938558 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
CTTGTCTTGCAATGACCGCAAACACCGACAAGGTGCACGGTGCCAACCGATTGAAACGAACGGGAACAAC
ATGACCGTCAAGACCATTGCGACCACGCCATACCAGGATCAACAGCCGGGCACTTCGGGCTTGCGCAAGA
AGGTTCCGGTTTTCCAGCAGCCCAATTATGCAGAAAATTTCATCCAGTCGATCTTCGACGTGCTGGAGGG
GTTCAAGGGCAAGACGCTCGTGGTTGGCGGCGACGGACGCTTTTATAACCGCGAGGTGATCCAGAAGCTT
ATCAAGATCGCAGCCGCCAACGGTTTTGGCCGTATCATGGTGGGACAGGGCGGCATTCTTTCCACGCCAG
CCGCCTCCAACATGATCCGCAAGTACAAAGCCTTCGGTGGCATGATCCTTTCGGCCAGCCACAATCCGGG
CGGGCCTACGCAGGATTTCGGCATCAAGTACAATATCGGCAATGGTGGACCGGCACCCGAAAAGATCACC
GAAGCGATCTTCGCCCGCTCAAAGGTGATCGACCAGTATAAAATTGCAGATGCAGCCGATATCGATATCG
ACAAGATCGGCACAAGCAAGATCGGCGATACCGAGGTGGTCATCTTCGATCCGGTGGCCGATTATGCTGA
ATTGATGGAAAGCCTGTTCGATTTCGCCGCCATCCGCGCCATGATAAAAGGCGGCTTCCAGATGAAGTTC
GACGCCATGCATGCGGTGACCGGGCCTTATGCCAAGGAAATCTTCGAGCGCCACCTCGGTGCGCCCGAAG
GCAGCGTCGTCAATTTCGTGCCCCTGCCGGATTTCGGTGGCCATCACCCGGATCCAAACCTCGTCTATGC
CAAGGATCTCTACGATCTTCTGATGTCCAGCCATGCGCCGGATTTTGGCGCCGCCTCCGACGGCGATGGC
GATCGCAACCTCATTCTCGGGCGCGGTATCTTCATCACGCCGTCAGATTCGCTTGCCATGCTGGCCGCAA
ATGCCCATCTGGCGCCGGGCTATAAAGGCGGTATCAAGGGCATTGCCCGTTCCATGCCGACGAGCGCCGC
CGCCGACCGCGTGGCGGAAAAACTCGGTATCGGCATGTATGAAACCCCGACCGGCTGGAAATTCTTCGGC
AATCTTCTCGACAGCGGCAAGGTGACGATCTGCGGCGAGGAAAGCTCCGGCACCGGCTCCGACCATGTGC
GCGAAAAAGATGGTTTGTGGGCCGTTCTGCTCTGGCTCAACATTCTGGCGGTGCGCAAGGAAAGTGTGAA
GGCAATCGCGGACGACCATTGGGCACGTTTCGGGCGCAATTATTACACTCGCCACGACTATGAAGCCGTC
GATTCCGATATTGCGACGAAGCTGGTGGCTGACCTGCGCGGCAAGCTTGCCGGCCTGCCCGGCACGAGCG
TCAATGGCCTCAGGATCGAAAAGGCCGACGACTTCGCCTATCATGATCCCGTTGATGGCTCGACCAGCGA
ACATCAGGGCATCCGCATCTATTTTGAAGGAGGTGCGCGCATCGTGCTTCGCCTGTCCGGTACCGGGACG
TCAGGCGCGACCATCCGCATCTATATCGAACGCTATGAAGCCGATCCTGCAAAACATAATCTCGACACGC
AGGCAACGCTGGCCCCACTGATCGACGCGGCTGAACAGATCGCCGAAGTAAAAAAACGCAGCGGGCGGAC
AGAGCCGTCGGTGGTTACTTG
Protein Sequence 
>gi|17988169|ref|NP_540803.1| phosphoglucomutase [Brucella melitensis bv. 1 str. 16M] MSCNDRKHRQGARCQPIETNGNNMTVKTIATTPYQDQQPGTSGLRKKVPVFQQPNYAENFIQSIFDVLEGFKGKTLVVGGDGRFYNREVIQKLIKIAAANGFGRIMVGQGGILSTPAASNMIRKYKAFGGMILSASHNPGGPTQDFGIKYNIGNGGPAPEKITEAIFARSKVIDQYKIADAADIDIDKIGTSKIGDTEVVIFDPVADYAELMESLFDFAAIRAMIKGGFQMKFDAMHAVTGPYAKEIFERHLGAPEGSVVNFVPLPDFGGHHPDPNLVYAKDLYDLLMSSHAPDFGAASDGDGDRNLILGRGIFITPSDSLAMLAANAHLAPGYKGGIKGIARSMPTSAAADRVAEKLGIGMYETPTGWKFFGNLLDSGKVTICGEESSGTGSDHVREKDGLWAVLLWLNILAVRKESVKAIADDHWARFGRNYYTRHDYEAVDSDIATKLVADLRGKLAGLPGTSVNGLRIEKADDFAYHDPVDGSTSEHQGIRIYFEGGARIVLRLSGTGTSGATIRIYIERYEADPAKHNLDTQATLAPLIDAAEQIAEVKKRSGRTEPSVVT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Brucella pgm encodes the phosphoglucomutase. The B. abortus pgm mutant (B2211) lacks the O antigen. However, the core region of the mutant LPS migrated in Tricine-PAGE electrophoresis in a position that was indistinguishable from that of the wild type core. Although the exponential intracellular replication of the pgm mutant was delayed by approximately 20 h with respect to that of the wild type, the high number of recoverable bacteria at 48 h postinfection indicates that mutant strain B2211 replicates inside HeLa host cells (Ugalde et al., 2000).

B abortus phosphoglucomutase (pgm) insertional mutants were attenuated in vivo but not in vitro (Ko and Splitter, 2003).
COG COG0033G, under G: Carbohydrate transport and metabolism
References
Ko and Splitter, 2003: Ko J, Splitter GA. Molecular host-pathogen interaction in brucellosis: current understanding and future approaches to vaccine development for mice and humans. Clinical microbiology reviews. 2003; 16(1); 65-78. [PubMed: 12525425].
Ugalde et al., 2000: Ugalde JE, Czibener C, Feldman MF, Ugalde RA. Identification and characterization of the Brucella abortus phosphoglucomutase gene: role of lipopolysaccharide in virulence and intracellular multiplication. Infection and immunity. 2000; 68(10); 5716-5723. [PubMed: 10992476].