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metH from Brucella melitensis bv. 1 str. 16M

Victor ID 1306
Gene Name metH from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197470
NCBI Protein GI 17988042
Locus Tag BMEI1759
Protein Accession NP_540676.1
Other Database IDs UniProtKB-ID: Q8YEW8_BRUME
UniRef100: UniRef100_Q8YEW8
UniRef90: UniRef90_B0CJ47
UniRef50: UniRef50_B3QGP3
UniParc: UPI00000581C3
EMBL: AE008917
EMBL-CDS: AAL52940.1
RefSeq_NT: NC_003317.1
HSSP: P13009
GenomeReviews: AE008917_GR
KEGG: bme:BMEI1759
NMPDR: fig|224914.1.peg.1758
HOGENOM: HBG289648
OMA: YVTDASR
ProtClustDB: PRK09490
BioCyc: BMEL224914:BMEI1759-MONOMER
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1802107
Gene Ending Position 1805892
Gene Strand (Orientation) -
Protein Name B12-dependent methionine synthase
DNA Sequence 
>gi|17986284:1802107-1805892 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
GTCAGGCCGCTTCGTCTTTCGATGCCCCAGGGACATAATTGAGGATCGGGGTGAGCCAGCGCTCCACAGC
CTCCACATCCATGTCCTTGCGCCGGGCATAATCCTCGACCTGATCGCGCTCCACCTTTGCCACACCGAAA
TAATAGCTTTCAGGGTGACCGATATAGAGACCCGACACCGAGGAGCCGGGCCACATGGCGTAGCTTTCGG
TAAGCTCCACGCCGGTATTGGCGGTGGCATCGAGCAGGCGGAACAAGGTGGTCTTTTCCGTATGATCGGG
CTGGGCCGGATAGCCCGGCGCCGGGCGGATGCCCTTATATGGCTCGCTGATCAGTTCTTCCGGCGTAAAG
GCTTCATCCGGCGCATAGGCCCAGAATTCCTTGCGCACACGCTCATGCATCAGTTCCGCGAAGGCTTCCG
CGAAACGATCGGCAAGCGCCTTCACAAGAATGGCGGAATAATCATCATTGGCGCGTTCAAAACGCTCTGC
GATAGCAATCTCGCCAATGCCCGCCGTCACGACAAAACCGCCAACATAATCCTGTTTGCCGCTTTCGACA
GGCGCCACAAAATCCGCCATGGCGACATTCGGGCGGCCATCGCGCTTGGTAAGCTGCTGGCGAAGCGTGA
ACAGGGTGGCAAGCTCCTCCTTGCGGCTTTCATCCGTAAAGAGGCGGATATCATCGCCCACCGCATTGGC
AGGCCAGAAGCCGACCACCGCCCGCGGGGTGAACCATTTCTCATCGATGATCTTCCGGAGCATCGCTTGC
GCATCCGCCCAGAGCTGGCGCGCCGCCTCACCCTGCTTTTCATCTTCGAGAATAGCCGGATAGCGGCCCC
TCAGTTCCCAGGTCTGGAAGAACGGGGTCCAGTCGATATAGCGCGCGATTTCCGCCAGATCATAGGTTTC
AAAAACCTTCGTTCCGGTGAAGGTCGGCTTCACCGGCTCGTAGTTTTCCCAGTCGAGCTGATGCGGATTG
GCGCGCGCGCGGGCAATTGGCAGGCGCTGTTTTTCAGCCTCGTTGCGGGCATGGGCAGCAGCCACCTTGG
CATATTCGTTGCGTAAACCGTCGATATAGGCCTGCTTGCCCTCCGGCGACAGGAGGTTTGACACGACCCC
CACCGCACGACTTGCATCCACGACATAGACAGCCTGCCCGCGCTCGTAACGCGAATGGATTTTCACCGCC
GTATGAACACGGCTCGTCGTCGCACCGCCAATCAAAAGCGGAATATCGAAGCCCTCGCGCTCCATTTCGG
CGGCGACATGCGCCATCTCATCAAGCGAAGGCGTGATGAGGCCGGAAAGGCCGATGATATCCACCTTTTC
ATCGCGCGCCACCTGCAGGATTTTCTGCGAGGGCACCATGACGCCAAGATCGATGATTTCATAATTATTG
CAGGCCAGAACCACGCCCACGATATTCTTGCCGATATCGTGCACATCGCCCTTGACGGTCGCCATCAGCA
CCTTGCCCGCACTCTGGCGGCCCTCGCCGCCATTGAGGCGCTTTTCCTCTTCCATGAAGGGCAGCAGCAC
GGCCACGGCCTGCTTCATCACGCGGGCAGATTTCACCACCTGCGGCAGAAACATCTTGCCGGAACCGAAC
AGGTCGCCGACCACATTCATGCCTGCCATCAGCGGCCCTTCGATCACATGCAACGGGCGCTCGGCAGCAA
GGCGCGCCTCTTCCGTATCGGCCTCGATATATTCGGTGATGCCGTTGACCAGCGCATGTTCAAGCCGCTT
TTCGACCGGCCATTCGCGCCAGCTCAAATCCTGCGTCCGCGCTTCCCTGGAGCCGGAATCACGGAACCGT
TCGGCAATTTCCAGAAGCCGTTCGGTTGCGCTTTCGCCCGTTTTTGTGGGGCGGTTCAGCACCACATCCT
CGCAAGCCTCACGCAGTTCAGCGTCGATCGTGTCATAGACCGCAAGCTGGCCCGCATTGACGATGCCCAT
ATCCATGCCCGCCTGAATGGCGTGGTAGAGGAAAACGGCATGCATCGCCTCACGCACCGGCTCATTGCCG
CGGAAGGAGAACGAGAGGTTGGAAACGCCGCCGGAAATATGGACATGCGGCAGTGTGCGGACGATTTCAC
GCGTGGCCTCGATGAAATCGACGCCGTAATTATTGTGTTCCTCGATGCCGGTCGCGACCGCAAAAATATT
CGGATCGAAAATGATGTCTTCCGGCGGGAAACCCACCTGTTCGGTCAGGATTTTATAGGCGCGGGTGCAG
ATTTCGATCTTGCGGGCCTGCGTATCCGCCTGTCCGGTTTCATCGAACGCCATGATGACCACAGCGGCAC
CATAGGCACGCACCAGCCGCGCATGGTGAAGAAAGGCTTCCTCACCCTCTTTCAGCGAGATGGAATTGAC
GACTGCCTTGCCCTGAACGCATTTCAGGCCAGCCTCGATCACTTCCCATTTGGAGCTGTCGAGCATGATC
GGCACGCGGGCGATATCCGGCTCGGCGGCAATAAGGTTCAAAAACTCGACCATGGCCTTTTCGGAATCGA
TCAGGCCTTCATCCATGTTGATATCGATGATCTGGGCGCCGTTGGCCACCTGATCGCGCGCAACATCGAG
CGCAGCCGCGAAATCGCCGGCCTTGACGAGCTTGCGGAAGCGGGCCGAGCCGGTGACATTGGTGCGCTCG
CCGATATTGACGAAAGGAATATCCTTGGTGAGCGTAAAGGGCTCAAGGCCGGAAAGGCGCATCAGCGGCG
GCACTTTTGCGGGCTTGCGTGGCTCATATTTCGCGACGGCTTGCGCGATGGCGCGAATATGGTCAGGCGT
GGAGCCGCAGCAGCCGCCAACAACATTGACCAGCCCGTCGCGAGCAAAGCCCTCGATCTGCGCGGCCATG
GCTTCCGGCGTTTCATCATACTGGCCGAATTCGTTCGGAAGGCCGGCATTGGGATAGGCGCAGATAAAGG
TGTCGGCAATGCCCGACAATTCATCCAGATGCGCACGCATGGCATTGGCGCCGAGGGCGCAATTCAGTCC
GATGGTGAACGGTCTTGCATGGCGCAGTGAATACCAGAAGGCCGTCGGCGTCTGGCCGGAAAGCGTGCGC
CCGGAAAGATCGGTGATCGTACCGGAGATCATGACCGGAAGGCGAACACCCTTTTCGGCAAAGACTTCCT
CGGTCGCGAACACAGCCGCCTTGGCGTTCAGCGTATCGAAAATGGTTTCGATCAGGATGATGTCGGAACC
GCCATCGATCAGGCCGCGAATCTGTTCGGAATAGGCAATGCGCACATCATCGAAAGTGACGGCGCGAAAG
CCCGGATTGTTCACATCCGGGGACAGCGAGGCGGTGCGGTTCGTCGGCCCCAGTGCGCCCGCGACAAAGC
GGCGGCGGCCGTCCTTCTGCTCGGCGCGCAAGGCTGCGCGGCGGGCAAGGCGTGCGCCATCGCGATTGAG
ATCATAGACCATCGCCTCCATGCCATAATCGGCCTGCGCGATGGAAGTGGAGGAGAAAGTATTGGTTTCG
AGAATATCCGCGCCCGCCATGGCATAGGCATAGTGGATTTCCTCAATGGCTTTCGGCTGGGTCAAGGTCA
GAAGATCGTTATTGCCCTGAAGCTGGCAGTCACAGGTGGCGAAACGATCGCCGCGAAAATGCTCTTCATG
GAAACCCAGGCCCTGAATCTGCGTACCCATGGCGCCGTCGAGGATCAGGATGCGCTCGCGCGCCGCCTGG
GTCAGTGCCGCCAGCACTTCCGAACCGTCCGGCTTTGCCGCCGTTGCACCAAAAAGATCGTCAAGGGAAG
ACGCCA
Protein Sequence 
>gi|17988042|ref|NP_540676.1| B12-dependent methionine synthase [Brucella melitensis bv. 1 str. 16M] MASSLDDLFGATAAKPDGSEVLAALTQAARERILILDGAMGTQIQGLGFHEEHFRGDRFATCDCQLQGNNDLLTLTQPKAIEEIHYAYAMAGADILETNTFSSTSIAQADYGMEAMVYDLNRDGARLARRAALRAEQKDGRRRFVAGALGPTNRTASLSPDVNNPGFRAVTFDDVRIAYSEQIRGLIDGGSDIILIETIFDTLNAKAAVFATEEVFAEKGVRLPVMISGTITDLSGRTLSGQTPTAFWYSLRHARPFTIGLNCALGANAMRAHLDELSGIADTFICAYPNAGLPNEFGQYDETPEAMAAQIEGFARDGLVNVVGGCCGSTPDHIRAIAQAVAKYEPRKPAKVPPLMRLSGLEPFTLTKDIPFVNIGERTNVTGSARFRKLVKAGDFAAALDVARDQVANGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPIMLDSSKWEVIEAGLKCVQGKAVVNSISLKEGEEAFLHHARLVRAYGAAVVIMAFDETGQADTQARKIEICTRAYKILTEQVGFPPEDIIFDPNIFAVATGIEEHNNYGVDFIEATREIVRTLPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDTIDAELREACEDVVLNRPTKTGESATERLLEIAERFRDSGSREARTQDLSWREWPVEKRLEHALVNGITEYIEADTEEARLAAERPLHVIEGPLMAGMNVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPFMEEEKRLNGGEGRQSAGKVLMATVKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPSQKILQVARDEKVDIIGLSGLITPSLDEMAHVAAEMEREGFDIPLLIGGATTSRVHTAVKIHSRYERGQAVYVVDASRAVGVVSNLLSPEGKQAYIDGLRNEYAKVAAAHARNEAEKQRLPIARARANPHQLDWENYEPVKPTFTGTKVFETYDLAEIARYIDWTPFFQTWELRGRYPAILEDEKQGEAARQLWADAQAMLRKIIDEKWFTPRAVVGFWPANAVGDDIRLFTDESRKEELATLFTLRQQLTKRDGRPNVAMADFVAPVESGKQDYVGGFVVTAGIGEIAIAERFERANDDYSAILVKALADRFAEAFAELMHERVRKEFWAYAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTLFRLLDATANTGVELTESYAMWPGSSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDVEAVERWLTPILNYVPGASKDEAA
Molecule Role Virulence factor
Molecule Role Annotation FUNCTIONAL GROUP: a.a. metabolism, Synthesis (Delrue et al., 2004).

FUNCTION: Met. synthesis (Delrue et al., 2004).

MUTATION: Attenuated in Mice, Macrophages, HeLa (Delrue et al., 2004).
COG COG1410E, under E: Amino acid transport and metabolism
References
Delrue et al., 2004: Delrue RM, Lestrate P, Tibor A, Letesson JJ, De Bolle X. Brucella pathogenesis, genes identified from random large-scale screens. FEMS microbiology letters. 2004; 231(1); 1-12. [PubMed: 14979322].