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hisD from Brucella melitensis bv. 1 str. 16M

Victor ID 1303
Gene Name hisD from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197379
NCBI Protein GI 17987951
Locus Tag BMEI1668
Protein Accession NP_540585.1
Other Database IDs UniProtKB-ID: D0B4X9_BRUME
UniRef100: UniRef100_Q8YF59
UniRef90: UniRef90_Q2YPB8
UniRef50: UniRef50_Q46WL2
UniParc: UPI0000058168
EMBL: GG703778
EMBL-CDS: EEW88453.1
RefSeq_NT: NC_003317.1
OMA: LLPEMPR
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1719545
Gene Ending Position 1720837
Gene Strand (Orientation) +
Protein Name histidinol dehydrogenase
DNA Sequence 
>gi|17986284:1719545-1720837 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
CATGGTCACAACGCTCAGACAGACCGACCCTGATTTTGAACAGAAGTTTGCGGCCTTCCTCTCCGGCAAG
CGCGAGGTTTCGGAAGATGTGGACCGTGCCGTGCGGGAAATCGTGGATCGTGTACGCCGCGAGGGTGACA
GCGCGCTGCTCGATTATTCACGCCGCTTCGACCGGATCGATCTGGAAAAGACCGGCATTGCCGTCACCGA
GGCCGAGATCGATGCCGCATTCGATGCCGCTCCCGCCTCCACCGTCGAAGCATTGAAGCTTGCGCGCGAC
CGTATCGAAAAGCACCATGCTCGCCAGTTGCCGAAGGACGACCGCTATACGGATGCGCTTGGCGTCGAGC
TTGGCTCGCGCTGGACGGCCATCAAGGCTGTCGGCCTCTATGTGCCTGGCGGCACGGCCAGCTATCCAAG
TTCCGTTCTGATGAATGCGATGCCCGCCAAGGTCGCAGGCGTGGACCGCATCGTCATGGTGGTGCCCGCA
CCCGATGGCAATCTCAATCCGCTGGTGCTGGTGGCAGCCCGCCTTGCAGGCGTGTCGGAGATTTACCGCG
TCGGCGGCGCGCAGGCCATTGCCGCCCTTGCCTATGGCACCGAAACGATCCGTCCCGTCGCCAAGATCGT
CGGCCCCGGCAATGCCTATGTGGCAGCGGCAAAGCGCATCGTATTCGGAACGGTCGGCATCGACATGATC
GCCGGGCCATCCGAAGTGCTGATCGTGGCCGACAAGGACAATAACCCGGACTGGATCGCCGCCGATCTTC
TGGCACAGGCCGAGCACGATACGGCCGCGCAATCCATCCTGATGACCAATGACGAGGCCTTTGCCCACGC
GGTGGAAGAAGCGGTCGAACGGCAGCTTCACACCCTGGCGCGCACTGAAACGGCTTCCGCAAGCTGGCGC
GATTTCGGTGCGGTCATTCTGGTCAAGGATTTCGAGGACGCAATTCCGCTTGCCAACCGTATTGCGGCCG
AGCATCTGGAAATCGCCGTGGCCGATGCGGAGGCGTTCGTACCGCGCATCCGCAATGCCGGTTCCATATT
CATTGGCGGTTATACACCGGAAGTGATCGGCGATTATGTGGGGGGCTGCAACCATGTGCTGCCAACGGCG
CGCTCTGCCCGTTTCTCCTCCGGCCTTTCGGTGCTCGATTATATGAAGCGCACCTCGCTTCTCAAGCTGG
GCTCCGAGCAGCTTCGCGCACTTGGACCGGCTGCGATCGAGATTGCACGCGCCGAGGGTCTCGATGCCCA
TGCCCAATCCGTCGCCATTCGTCTGAACCTATG
Protein Sequence 
>gi|17987951|ref|NP_540585.1| histidinol dehydrogenase [Brucella melitensis bv. 1 str. 16M] MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIKAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAHAQSVAIRLNL
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine (By similarity)(UniProt: Q8G2R2).

CATALYTIC ACTIVITY: L-histidinol + 2 NAD(+) = L-histidine + 2 NADH(UniProt: Q8G2R2).

COFACTOR: Binds 1 zinc ion per subunit (By similarity)(UniProt: Q8G2R2).

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9 [final step](UniProt: Q8G2R2).

SIMILARITY: Belongs to the histidinol dehydrogenase family(UniProt: Q8G2R2).

MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis hisD gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0141E, under E: Amino acid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].