Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

pgi from Brucella melitensis bv. 1 str. 16M

Victor ID 1301
Gene Name pgi from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197347
NCBI Protein GI 17987919
Locus Tag BMEI1636
Protein Accession NP_540553.1
Other Database IDs UniProtKB-ID: D0B508_BRUME
UniRef100: UniRef100_C0RH03
UniRef90: UniRef90_B2S928
UniRef50: UniRef50_A9M7X1
UniParc: UPI000005814A
EMBL: GG703778
EMBL-CDS: EEW88482.1
RefSeq_NT: NC_003317.1
OMA: MRDWFSK
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1686967
Gene Ending Position 1688616
Gene Strand (Orientation) -
Protein Name glucose-6-phosphate isomerase
DNA Sequence 
>gi|17986284:1686967-1688616 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
GTCAAGCTTTCCTTCGCGCATGCAGATGCGCGACAAGCCCTTGCGTGGAAGCGTCGCGACCACTCGCCCC
TTCCTTGCCCGATACAACCGGCAAAAGTTCCGTCGCCAGTTCCTTACCCAGTTCCACGCCCCATTGATCG
AAGGCATTGATGCCGAAAATCTGCGCTTCGACGAAAACACGATGTTCGTAAAGCGCGATCAGGCGACCCA
GCGTATAGGGGTCGAGCATGTCATGGATGAGCGTCAGGGATGGGCGGTTGCCGGAAAAGACGCGGTGCGG
GGCAATGCGCTCCACTTGCGACGCAGGCAGGTTCTTTGCCTGCAACTGCGCACGCGCCTCGTCCAGCGTG
CGGCCTTTCATCAGGGCTTCGGACTGGGCAAGGCAGTTTGCCATCAGCATTTCATGCTGGTGATCCAGTG
TCGGCTCGTGGCCCTTGGCCGCCACGATGAATTCCAGCGGGATCGTATCGGTTCCCTGATGCAGAAGCTG
GAAAAAGGCGTGCTGGCCATTGGTGCCGGGCTCACCCCAGACAACGGGGCCGGTTGGGCCGGAAACCGGC
TTGCCATCCAGCGTCACGCTCTTGCCGTTCGATTCCATATCGAGCTGCTGCAAATAGGCCGGGAGGCGCG
AAAGGCGCTGGTCATAAGGAATGATGGCGCGGCTGCCATAACCGCAGATTGCGCGATGCCAATAGCCGAT
GAGGCCGAGCATGACGGGCAGGTTCTTTTCCAGTGGCGCATCGCGGAAATGCACATCCATGGCGTGTGCG
CCCGCAAGGAACTTGCGGAAATTATCCGGGCCGACGGCGATCATCACCGGCAGGCCGATGGCCGACCAGA
CCGAATAACGCCCGCCAACCCAGTCCCAGAAGCCGAAAACACGATCTTCAGGAATGCCGAAGGCCGCAAC
CTTGTCGAGCGCAGTGGAAACGGCAGCAAAATGCGCGCCCACCGCCGCCTCGCCCAGGGTGTCTGCCACC
CATTTGCGCGCCGTCTGCGCGTTCGTCATGGTTTCAATGGTCGTAAAAGTCTTCGACGCGACAATGATAA
GCGTCGATGCCGGATCAAGCGGCGAAAGCGTGTCGGCAATATGCGCGCCATCGATATTGGAAACGAAATG
CGCGCGTGGCTCATCATGATAGGGCGCAAGCGCCAGCGTCGCCATGACAGGCCCCAGATCGGAACCGCCA
ATGCCGATATTCACGATATCGGTAATCTTCCGGCCGGTCGCGCCCTTCAACGCGCCGGACCGGATGCCAT
CCGCAAAAGCGGCCATGCGGTCGAGCACATGTTTCACATCCGGCAGTACATTATGCCCGTCAACCAGCAC
TTCCTTCGAGGACGTGTCGCGCAGCGCCACATGCAGAACGGCGCGGTCTTCGGTATTGTTGATATGCTCG
CCCGCGAACATGGCGGCGCGGCGCCCTTCCACATCGGCAGCGACGGCCAGCTCTTTCAACAGCGCCATGG
TCTCGTCGTTAACCCGGCACTTCGACCAGTCGAACAGAAGATCATCCAGGCAGAGCGAATATCGCCCGAA
CCGGCCGGGGTCGGCGCTGAATGCCGCGCGCATATCGCGCGGGGCCGATTCCGCCCAATGCTTTTTCAGC
TTTGCGACCGTTGCTTCAAGCTTCGTCGCGTCTCTTGCCA
Protein Sequence 
>gi|17987919|ref|NP_540553.1| glucose-6-phosphate isomerase [Brucella melitensis bv. 1 str. 16M] MARDATKLEATVAKLKKHWAESAPRDMRAAFSADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHDEPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRKA
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: D-glucose 6-phosphate = D-fructose 6-phosphate(UniProt: Q8G2N3).

PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2(UniProt: Q8G2N3).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8G2N3).

SIMILARITY: Belongs to the GPI family(UniProt: Q8G2N3).

MUTATION: B. suis pgi is a gene identified by signature-tagged mutagenesis. The mutant is attenuated inside THP1 macrophages. The mutation of the pgi gene could also affect the biosynthesis of the bacterial peptidoglycan (Foulongne et al., 2000).
COG COG0166G, under G: Carbohydrate transport and metabolism
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].