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pyrD from Brucella melitensis bv. 1 str. 16M

Victor ID 1300
Gene Name pyrD from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197322
NCBI Protein GI 17987894
Locus Tag BMEI1611
Protein Accession NP_540528.1
Other Database IDs UniProtKB-ID: D0B532_BRUME
UniRef100: UniRef100_C0RH28
UniRef90: UniRef90_B2S953
UniRef50: UniRef50_A5EA61
UniParc: UPI0000058131
EMBL: GG703778
EMBL-CDS: EEW88506.1
RefSeq_NT: NC_003317.1
OMA: AALNRMG
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1658174
Gene Ending Position 1659268
Gene Strand (Orientation) +
Protein Name dihydroorotate dehydrogenase 2
DNA Sequence 
>gi|17986284:1658174-1659268 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
AATGAGTGGGCTTTTTGAAACTCTGGGGCGGCGCGCCCTCTTCACCTTCGATGCGGAACAGGCACACGGC
CTTTCCATCACCGGGCTGAAAACCGGGATCGTCACTTGCCGCACGCCCGAAGATCCGGCCCTTTCGGTAA
AGGTGGCGGGGCTGAAATTTCCCAATCCGCTCGGCATGGCTGCCGGTTACGACAAGAATGCCGAAGTGCC
GGATGCGCTGCTGAAGCTTGGATTCGGCTTTGCGGAAGTCGGCACACTGACCCCCCGCCCGCAAAGCGGC
AATCCGCGCCCGCGCATTTTCCGACTTGTGGACGACAAGGCCGTCATCAACCGCCTCGGCTTCAACAATG
AGGGCCATGAAGCCGCCTTCAAGCGTCTTTCCAGGCGCGCAGGCAAGAGCGGCATTGTCGGCGTCAACAT
CGGCGCGAACAAGGATGCCGAAGACCGGATCGCGGATTATGTGGCCGGTATCCGCCGCTTCTATCAGCTG
GCGCGCTATTTCACGGTCAATATTTCCTCACCCAACACGCCGGGGCTGCGCAATCTCCAGGCGCGCGAGG
CCCTGCACGAGCTTTTGAGCCGTGTTCTGGAAGCGCGCGACGAGGAGGGAAATATGTGCACGCTGAAGCG
GCCCGTTTTCCTGAAGATTGCGCCTGATCTCACCGATGAGGAACTGGACGATATCGCCGCCGAAGCAGAT
GCGCAGAAGCTGGACGGCATCATTGTTTCCAACACGACACTATCGCGAAGCGGGCTTAAAAATCCCGAAA
ACAGCAATGAAACCGGCGGGCTTTCCGGTGCGCCGCTGTTTGAACGCTCGACCGTGGTTCTGGCGCGGAT
GCGCGAGCGCGTCGGCCCCGATATGCCGCTGATCGGCGTGGGCGGCATCGACAGTGCCGAAACGGCGCTG
GCCAAGATCAAGGCAGGCGCCGATCTGGTGCAGCTTTATAGCGGGCTGATCTATCGCGGCCCCGGCCTTC
CGGGTGAAATCCTGCGCGGCCTTTCCACGGCAATCAAGTATGAAGGCGTTTCCAGCATTGCTGAATTGCG
CGACCGTGACACAAAGGAATGGGCCGCACGCAAACTTATATCTTA
Protein Sequence 
>gi|17987894|ref|NP_540528.1| dihydroorotate dehydrogenase 2 [Brucella melitensis bv. 1 str. 16M] MSGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMAAGYDKNAEVPDALLKLGFGFAEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHEAAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFYQLARYFTVNISSPNTPGLRNLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGIIVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAETALAKIKAGADLVQLYSGLIYRGPGLPGEILRGLSTAIKYEGVSSIAELRDRDTKEWAARKLIS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: B. suis pyrD mutation study indicated that pyrimidine synthesis pathway contributes to intracellular growth (Kim et al., 2003).
COG COG0167F, under F: Nucleotide transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].