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bacA from Brucella melitensis bv. 1 str. 16M

Victor ID 1297
Gene Name bacA from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197264
NCBI Protein GI 17987836
Locus Tag BMEI1553
Protein Accession NP_540470.1
Other Database IDs UniProtKB-ID: D0B589_BRUME
UniRef100: UniRef100_D0B589
UniRef90: UniRef90_C0RH86
UniRef50: UniRef50_Q08120
UniParc: UPI00000580F7
EMBL: GG703778
EMBL-CDS: EEW88563.1
RefSeq_NT: NC_003317.1
OMA: TMRFSST
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1597280
Gene Ending Position 1598527
Gene Strand (Orientation) -
Protein Name transport protein
DNA Sequence 
>gi|17986284:1597280-1598527 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
ATCAGCCCGCCCCTGGTTCGAGATTGATCCGATCCACCGCCTGTAGCGGCTCGCCATGAATGGCTGCCTC
AAAGGCGCGAAGGCGCTTGTAGATCGACAGAAGCTCGATGATCGTCGTCCATGAATTGACCAGATACTGG
AACGATCCGCGCACCTGATCGAACACGTTGGTAATCTGGCTCATCAGGCCAAGCGTTAGCTTGTCCGCGA
CAATCGACGGGATCAGGATGATGAGCGGAAAGATATTGTCCACCTGCAAATAGAAAATGCGCGCCACATT
GAAATAGACATAGTGGAAATAAAGCCGGAAATAATTGTGCCGGACATTCTTGAACAGTTCGCGCATCGTG
ATCGGTTCAGCACGGTCGGCATGGTCTTCGCCATAGACGAGTTCCTTACGGTAGGCGGCCTCGACCCGCT
GGTTGTTGAACTCCAGACCGGGCAGCTTGATGCCCACCAGCGCCAGGAAGCCGGTGCCGAACAGCGCCCA
GATGACCGCCGCCCAGACCAGCGCATGGGGAACATAGCCGATGATCGGCAGCGTGCTGACCTTTTGGGAA
AAGGTGAACAGGACGGGCAGGAAGGCGATGAGGGTCATGACGGATTTCACGAGGCTGACGCCCAGCTGTT
CCAGCGTGGTGGAAAAGCGCATCGTATCTTCCTGCACACGCTGGGCCGCACCCTCGATATGGCGCAATTT
CGGCCAATGGCTCATGTAATAATCGTTCATCGCCGTGCGCCAGCGGAAGATATAATGGCTGACGAAGAAG
AGGTTCAGCACGCCAATGGTGATGGCGAGGAAAGCAATGCCTGCAAAATCGGCCAGCCCCCAGTAGAATT
CCGCAGCCGAGACCGCGCCGGGCGTCGTCAGCCCCTTCTGCACCATATCGTAGAACGGGCCATACCAAGT
ATTGATTGCCACACTCACCTGAACGTTGAAATAGGTGGCGAACAGAATGAGGGCAGAACCGAGGATTGAC
CATCTCTGCCAGGGATGTGGGGAAAAACGCACCCAGAAGCCATAAAAGGCGAAGGTAATGACGGCGAAAT
AAATATAGAACCAGAGGAAGGGCCGCGACCAGAACACATGCGCGCCAATGAGAGGCGCGGCATCGCTTGC
GGCTGGCGCAAGGCCGAACACGCTGCCCAGATTTTCACCGCCCATATACCAGCCAAGAACTGCGAGCAGG
GTCCACAAAAGTGCAGATATGAAGAACAGTTTCGGACGGGGGAAAAATGACGCAAACA
Protein Sequence 
>gi|17987836|ref|NP_540470.1| transporter [Brucella melitensis bv. 1 str. 16M] MFASFFPRPKLFFISALLWTLLAVLGWYMGGENLGSVFGLAPAASDAAPLIGAHVFWSRPFLWFYIYFAVITFAFYGFWVRFSPHPWQRWSILGSALILFATYFNVQVSVAINTWYGPFYDMVQKGLTTPGAVSAAEFYWGLADFAGIAFLAITIGVLNLFFVSHYIFRWRTAMNDYYMSHWPKLRHIEGAAQRVQEDTMRFSTTLEQLGVSLVKSVMTLIAFLPVLFTFSQKVSTLPIIGYVPHALVWAAVIWALFGTGFLALVGIKLPGLEFNNQRVEAAYRKELVYGEDHADRAEPITMRELFKNVRHNYFRLYFHYVYFNVARIFYLQVDNIFPLIILIPSIVADKLTLGLMSQITNVFDQVRGSFQYLVNSWTTIIELLSIYKRLRAFEAAIHGEPLQAVDRINLEPGAG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: B abortus bacA mutant exhibited decreased survival in macrophages and greatly accelerated clearance from experimentally infected mice compared to the virulent parental strain (LeVier et al., 2000). R meliloti bacA gene encodes a putative cytoplasmic membrane transport protein required for symbiosis (LeVier et al., 2000). The BacA protein is essential for the long-term survival of Sinorhizobium meliloti and Brucella abortus within acidic compartments in plant and animal cells , respectively. Mutation study showed that B. abortus BacA affects the distribution of LPS fatty acids, including a very-long-chain fatty acid thought to be unique to the alpha-proteobacteria(Ferguson et al., 2002).
COG COG1133I, under I: Lipid transport and metabolism
References
Ferguson et al., 2002: Ferguson GP, Roop RM 2nd, Walker GC. Deficiency of a Sinorhizobium meliloti BacA mutant in alfalfa symbiosis correlates with alteration of the cell envelope. Journal of bacteriology. 2002; 184(20); 5625-5632. [PubMed: 12270820].
LeVier et al., 2000: LeVier K, Phillips RW, Grippe VK, Roop RM 2nd, Walker GC. Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival. Science (New York, N.Y.). 2000; 287(5462); 2492-2493. [PubMed: 10741969].