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aroC from Brucella melitensis bv. 1 str. 16M

Victor ID 1294
Gene Name aroC from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197217
NCBI Protein GI 17987789
Locus Tag BMEI1506
Protein Accession NP_540423.1
Other Database IDs UniProtKB-ID: D0B1N8_BRUME
UniRef100: UniRef100_B2S9R7
UniRef90: UniRef90_B2S9R7
UniRef50: UniRef50_Q2Y7L8
UniParc: UPI00000580C8
EMBL: GG703778
EMBL-CDS: EEW88610.1
RefSeq_NT: NC_003317.1
OMA: SRFTTQR
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1553675
Gene Ending Position 1554769
Gene Strand (Orientation) -
Protein Name chorismate synthase
DNA Sequence 
>gi|17986284:1553675-1554769 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
GTCAGACGCGGCCAGTCTGGCCGCGGTGGCGCAGATAGTGATCGGCAATGGCGCAGGCAACCATGGCCTC
ACCGATCGGCACGGCGCGGATGCCCACGCACGGATCGTGACGGCCCCTCGTCATCACATCAACCTCATTG
CCGTCCTTATCGATGGAACGGCGCGGCGTGAGGATCGATGACGTTGGCTTGACCGCAAAACGCGCCACCA
CCGGCGCGCCCGTTGCTATGCCGCCCAGAACACCGCCCGCATGATTGGAAAGAAAAATCGGCTTGCCGTC
ATTGCCCATGCGCATTTCATCGGCATTTTCCTCGCCGGTGAGGCGCGCAGCCTCGAAGCCATTGCCGATT
TCCACGCCCTTCACGGCGTTGATCGACATGAGATAGCTCGCGATATCCTGATCCAGCTTGCCGTAGATCG
GCGCACCGATGCCAGCCGGTACACCCTCGGCCACGATTTCGATGATCGCACCGACCGATGAGCCGTTCTT
GCGGATACCGTCGAGATAGTCGGCGAAAACCTCCACCGAACCGGCATCCGGCGTGAAGAAGGGATTATTG
TCCACTTCCGCCCAGTTCCAGCGGCTGCGGTCGATATCGTGCGCACCGATGGAAACGAGTGCGCCCCTGA
CTTCCAGTCCCGGAACGACCTTGCGGGCAATGGCACCCGCCGCCACACGCGCCGCCGTTTCGCGTGCGGA
AGACCGTCCGCCGCCGCGATAATCACGAATGCCATATTTCACATCATAGGCGTAATCGGCATGGCCGGGA
CGGTATTGCCGGGCGATCTCGCCATAATCCTTGGAACGCTGATCGGTATTTTCGATCATCATGGAGATGG
GCGTGCCGGTGGTGGTCATGGTCACACCATCCTCGCCCAGAAGCACGCCGGAAAGCACGCGCACCTGATC
CGGCTCGCGGCGCTGCGTGGTATATTTCGACTGGCCCGGCTTGCGCTTGTCGAGAAAGGACTGGATTTCG
GCTTCGGTGAAGGTAATTCCGGGGGGGCAGCCATCCACGACGCAACCAAGCGCCAGACCGTGGCTTTCGC
CCCAAGTGGTTACGCGGAACAGATGACCGAAACTATTATGAGACA
Protein Sequence 
>gi|17987789|ref|NP_540423.1| chorismate synthase [Brucella melitensis bv. 1 str. 16M] MSHNSFGHLFRVTTWGESHGLALGCVVDGCPPGITFTEAEIQSFLDKRKPGQSKYTTQRREPDQVRVLSGVLLGEDGVTMTTTGTPISMMIENTDQRSKDYGEIARQYRPGHADYAYDVKYGIRDYRGGGRSSARETAARVAAGAIARKVVPGLEVRGALVSIGAHDIDRSRWNWAEVDNNPFFTPDAGSVEVFADYLDGIRKNGSSVGAIIEIVAEGVPAGIGAPIYGKLDQDIASYLMSINAVKGVEIGNGFEAARLTGEENADEMRMGNDGKPIFLSNHAGGVLGGIATGAPVVARFAVKPTSSILTPRRSIDKDGNEVDVMTRGRHDPCVGIRAVPIGEAMVACAIADHYLRHRGQTGRV
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate(UniProt: P63608).

COFACTOR: Reduced flavin (By similarity)(UniProt: P63608).

PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 7 [final step](UniProt: P63608).

PATHWAY: Context: Aromatic amino acids biosynthesis(UniProt: P63608).

SUBUNIT: Homotetramer (By similarity)(UniProt: P63608).

SIMILARITY: Belongs to the chorismate synthase family(UniProt: P63608).

MUTATION: The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was highly attenuated in it issue culture (THP1 macrophages and HeLa cells) and murine virulence models (Foulongne et al., 2001).
COG COG0082E, under E: Amino acid transport and metabolism
References
Foulongne et al., 2001: Foulongne V, Walravens K, Bourg G, Boschiroli ML, Godfroid J, Ramuz M, O'Callaghan D. Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models. Infection and immunity. 2001; 69(1); 547-550. [PubMed: 11119550].