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spotT from Brucella melitensis bv. 1 str. 16M

Victor ID 1274
Gene Name spotT from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1197007
NCBI Protein GI 17987579
Locus Tag BMEI1296
Protein Accession NP_540213.1
Other Database IDs UniProtKB-ID: RSH_BRUME
UniRef100: UniRef100_Q8YG65
UniRef90: UniRef90_A5VPI9
UniRef50: UniRef50_A5VPI9
UniParc: UPI000164916A
EMBL: AE008917
EMBL-CDS: AAL52477.1
RefSeq_NT: NC_003317.1
HSSP: Q54089
GenomeReviews: AE008917_GR
KEGG: bme:BMEI1296
NMPDR: fig|224914.1.peg.1295
HOGENOM: HBG594146
ProtClustDB: CLSK864835
BioCyc: BMEL224914:BMEI1296-MONOMER
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1342358
Gene Ending Position 1344640
Gene Strand (Orientation) -
Protein Name GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE
DNA Sequence 
>gi|17986284:1342358-1344640 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
CCTATCCGTTCACACGCTTTGCGCTGCTGACGCTCGCGCTTTCTTTCAATTGAGAGATGATGCGATTGAG
ATGCTTGAGGTCCCAGACCTCTACATCGATAATCATTTCCGTAAAATCGGGCGCCGTGCGCACCATGGAG
AGATTGTGGATATTGGCATCATTTGCCGCCGCAATCTGGGCAATTTCCGCCAAAGAGCCGGGCGAGTTGA
TTGCCGATACGCTGATGCGCGCGGGGAAACGCTCGCTCATCTGGTCATCGATATCCCAGCGCACGTCGAT
CCAGCGCTCCGGCTGATCGTCATAGGCCGTCAGTGCGGGCGACTGGATGGGATAGATCGTGATGCCTGCG
CCGGGCTGCAAGATGCCCACGATGCGGTCGCCCGGCACGGCCCCTTCCGGCGCAAAACGCACAGGCAGGT
CCGGATTGGTTCCGCGAATGGGCAGTGCGCGCTTGCCGGGCTTCGGCGTCGTTGCCGCCGGATCAACCTT
GGCAGCAGCACCCTCGCCTCCTTCCGGCACCTTGAAGATCATGCCAGCGGCGTTCTGGATATTGAACCAG
CCCTTCTCGCCAGCCTTGGCAGGATTGTTCTGCGTGGTGACGCGAGTGTCCTGATAATCGGGATAGACGG
CCTTCACCACATCGGTCGAGGGCAGTTCCCCACGCCCGACGGCTGCAAGCACGTCTTCCACATCCTTGCG
CGCCAGACGCGGCAGGCCAGGCTTCAAAATGTCCTTGCTGAACGGTTTGCCCGCGCGCTCAAAGGCACGC
TCCAGAATTCGCATCCCGAGGCCGGAATATTGCTTGCGCACGGCAGAGCGTGTGGCGCGGCGGATGGCCG
CGCGCGCCTTGCCGGTTGCAACCAGCGATTCCCAGGCGGCGGGCGGAACCTGCGCCTTGGAGCGGATAAT
ATCCACTTCGTCGCCATTCTTGAGTTCCGTCATCAAGGGCATGATGCGGCCATTGACTTTCGCGCCCACG
CAGCTGTCGCCAATATCGGTGTGAACGGCATAGGCAAAATCAATAGGCGTCGCGCCGCGCGGCAGCGCGA
TCAGCCTGCCTTTCGGCGTGAAGCAGAAGACCTGATCTTGAAACAGTTCAAGCTTGGTGTGTTCCAGAAA
TTCTTCAGGATTGTCGCCCTCAGACAATTGCTCGATGGTCTGGCGCAGCCATGCATAGGCGTTGGTCTCG
GTCGAAATCTTGTGCGGGTTGTTGGCGCTGCCACGATCCTTGTAAATGGAGTGGGCCGCCACGCCGAATT
CAGCGATCTCATCCATTTCGCGCGTGCGAATCTGCAATTCGATACGCTGGCGCGACGGGCCGATGATGGT
GGTATGGATGGAGCGATAATCGTTCTGCTTCGGCGTCGAGATATAATCCTTGAACCGTCCCGGAACCATG
GACCATGTGGTGTGGATCAGGCCAAGCGCACGATAGCAATCCTGCACCGTATCGACCATGACGCGGAAGC
CGAAAATGTCGGAAAGCTGCTCGAAGGAAAGGCCCTTGCTCTCCATCTTGCGGAAAACCGACCATGGCTT
CTTCTGGCGGCTTTTCACGCTGGCCTTGATGCCGTTCTTCTCGAAAATTTCAGAGAGATCCGTTTCGATC
TTCTGCAAAAGACCGCGGTTCTTTTCCAGAAGCTCGGCAAGCCTGTCGGTGACGGCTCGCCATGCATCGG
GATTGATATAGCGGAAAGCCAGCTCCTCCAGCTCCTCACGCATATCCTGCATACCCATGCGGCCAGCGAG
CGGCGCATAAATATCCATGGTCTCCTCGGCAATACGCAGGCGCTTGTCTTCGCGCATCACGCCGAGCGTA
CGCATATTGTGGAGACGGTCGGCAAGCTTTACCAGAAGAACGCGCACGTCCTCTGAAATCGCCAGCAGAA
GTTTACGCAGGTTTTCCGCCTGGACAGCCTTCTTGGAAACGAGATCGAGTTTCTTGAGCTTGGTCAGCCC
CTCGACAAGCTTGCCGATTTCCGGCCCGAAAAGCTGGTCGATTTCCTGCCGGGTGGCCGTGGTATCCTCG
ATCGTGTCGTGCAGAAGCGCGATGGCGATTGTCGCCTCGTCCAAATGCATATCTGTTAGAATAGCCGCCA
CTTCCAGCGGATGGGAGAAATAGGGATCGCCGGAAGCCCGCTTCTGACTGCGGTGTTTCTGCATGGCATA
AACATATGCCTTGTTAAGAAGCGCCTCGTTCACATCAGGCTTGTATCGCTGCACACGCTCCACAAGCTCA
TATTGGCGCATCATCTGCCGAAACTCCCTCGAACCGAAACACA
Protein Sequence 
>gi|17987579|ref|NP_540213.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Brucella melitensis bv. 1 str. 16M] MCFGSREFRQMMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHRSQKRASGDPYFSHPLEVAAILTDMHLDEATIAIALLHDTIEDTTATRQEIDQLFGPEIGKLVEGLTKLKKLDLVSKKAVQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLGVMREDKRLRIAEETMDIYAPLAGRMGMQDMREELEELAFRYINPDAWRAVTDRLAELLEKNRGLLQKIETDLSEIFEKNGIKASVKSRQKKPWSVFRKMESKGLSFEQLSDIFGFRVMVDTVQDCYRALGLIHTTWSMVPGRFKDYISTPKQNDYRSIHTTIIGPSRQRIELQIRTREMDEIAEFGVAAHSIYKDRGSANNPHKISTETNAYAWLRQTIEQLSEGDNPEEFLEHTKLELFQDQVFCFTPKGRLIALPRGATPIDFAYAVHTDIGDSCVGAKVNGRIMPLMTELKNGDEVDIIRSKAQVPPAAWESLVATGKARAAIRRATRSAVRKQYSGLGMRILERAFERAGKPFSKDILKPGLPRLARKDVEDVLAAVGRGELPSTDVVKAVYPDYQDTRVTTQNNPAKAGEKGWFNIQNAAGMIFKVPEGGEGAAAKVDPAATTPKPGKRALPIRGTNPDLPVRFAPEGAVPGDRIVGILQPGAGITIYPIQSPALTAYDDQPERWIDVRWDIDDQMSERFPARISVSAINSPGSLAEIAQIAAANDANIHNLSMVRTAPDFTEMIIDVEVWDLKHLNRIISQLKESASVSSAKRVNG
Molecule Role Virulence factor
Molecule Role Annotation FUNCTIONAL GROUP: Regulation (Delrue et al., 2004).

FUNCTION: ppGpp synthetase (Delrue et al., 2004).

MUTATION: Attenuated in Macrophages, HeLa (Delrue et al., 2004).
COG COG0317TK, under T: Signal transduction mechanisms; K: Transcription
References
Delrue et al., 2004: Delrue RM, Lestrate P, Tibor A, Letesson JJ, De Bolle X. Brucella pathogenesis, genes identified from random large-scale screens. FEMS microbiology letters. 2004; 231(1); 1-12. [PubMed: 14979322].