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purM from Brucella melitensis bv. 1 str. 16M

Victor ID 1269
Gene Name purM from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1196951
NCBI Protein GI 17987523
Locus Tag BMEI1240
Protein Accession NP_540157.1
Other Database IDs UniProtKB-ID: D0B2E1_BRUME
UniRef100: UniRef100_C0RI52
UniRef90: UniRef90_A6X235
UniRef50: UniRef50_A6X235
UniParc: UPI0000057FC1
EMBL: GG703778
EMBL-CDS: EEW88863.1
RefSeq_NT: NC_003317.1
OMA: HYDLAGF
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1288821
Gene Ending Position 1289900
Gene Strand (Orientation) +
Protein Name phosphoribosylaminoimidazole synthetase
DNA Sequence 
>gi|17986284:1288821-1289900 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
CATGACCATGGAAAACAAGCCCGCCGGCCAAAACGGCCTGACCTATGCGCAGGCTGGTGTTGATATCGAT
GCCGGCAACCTGATGGTCGAAAAGATCAAGCCATTGGTGCGCTCGACACGCCGCCCCGGTGCGGATGGCG
AAATCGGCGGGTTCGGCGGTTTGTTCGATCTCAAGGCTGCGGGCTTCAAGGGTCCGGTTCTGGTTGCGGC
CAATGATGGTGTCGGCACCAAGCTCAAGATCGCTATTGATGCGGATATCCATGATACTGTCGGCATCGAT
CTCGTGGCGATGTGCGTGAACGATCTGGTCGTGCAGGGCGCGGAACCGCTTTTCTTTCTTGATTATTACG
CCACCGGCAAGCTTTCGCCGGATCAGGGCGTCGCGATCGTTTCGGGCATCGCGGAAGGCTGCCGTCAGGC
GGGCTGCGCACTGATCGGCGGTGAGACGGCGGAAATGCCGGGCATGTATCGCGACGGCGATTACGATCTT
GCAGGTTTTGCCGTGGGCGCAGCAGAACGTGACCGCCTGCTGCCGCGCGGCGATATTGCCGAAGGCGACA
TCATTCTGGGCCTTGCTTCCTCGGGCGTTCATTCCAACGGCTTCTCGCTTGTGCGCCGCATCGTCGAGCT
TTCCGGCCTCGGCTGGAAGTCGCAGGCCCCTTTCCAACCGGGCGCAACGCTCGGTGAAGCCCTGCTCACC
CCGACGCGGATTTACGTCAAGCCGCTGCTCGCCGCCATCCGTGCCTGCGACGGCATCAAGGCGCTGGCGC
ATATTACAGGCGGCGGCTTCCCCGACAATATTCCCCGCGTCCTGCCGAAAGGCCTGGCTGCGGAGATTGA
TCTTCCGGCCATTGCAGTCCCGCCGGTTTTCTCCTGGCTTGCCAAGACTGGCAATGTCGAACCGAATGAA
ATGCTGCGCACCTTCAATTGCGGCATCGGCATGATTGCGGTCGTCAATCCGGCAAAGGTCGATGAAGTGA
TCGCAGCACTTGCAGCCGAAGGCGAAAAGGTCGTTACACTCGGCCGCATGACCCGGCGTGAGAAAGACGG
CGTCATCTACAAGGGCCAGCTCGCACTATG
Protein Sequence 
>gi|17987523|ref|NP_540157.1| phosphoribosylaminoimidazole synthetase [Brucella melitensis bv. 1 str. 16M] MTMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAAGFKGPVLVAANDGVGTKLKIAIDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAAERDRLLPRGDIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVKPLLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVEPNEMLRTFNCGIGMIAVVNPAKVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole(UniProt: Q8G1K5).

PATHWAY: Nucleotide biosynthesis; IMP biosynthesis; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2(UniProt: Q8G1K5).

PATHWAY: Context: Purine biosynthesis(UniProt: Q8G1K5).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8G1K5).

SIMILARITY: Belongs to the AIR synthase family(UniProt: Q8G1K5).

MUTATION: B. abortus purM gene is essential for intracellular growth in HeLa cells as shown from transposon mutagenesis study (Kim et al., 2003).
COG COG0150F, under F: Nucleotide transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].