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glnA from Brucella melitensis bv. 1 str. 16M

Victor ID 1255
Gene Name glnA from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1196690
NCBI Protein GI 17987262
Locus Tag BMEI0979
Protein Accession NP_539896.1
Other Database IDs UniProtKB-ID: D0B345_BRUME
UniRef100: UniRef100_D0B345
UniRef90: UniRef90_A9MB20
UniRef50: UniRef50_P00964
UniParc: UPI0000057EBD
EMBL: GG703778
EMBL-CDS: EEW89117.1
RefSeq_NT: NC_003317.1
OMA: FAEGTMF
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 1019822
Gene Ending Position 1021231
Gene Strand (Orientation) +
Protein Name GLUTAMINE SYNTHETASE
DNA Sequence 
>gi|17986284:1019822-1021231 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
AATGACGACTGCCAACGATATTCTGAAACAGATCAAAGATAACGACGTCAAGTTCGTCGACCTTCGCTTC
ACCGATCCGAAGGGCAAGCTCCATCACGTTACGATGGATATCGGCCTCGTGGACGAAGACATGTTCGTCG
ACGGTGTCATGTTCGACGGCTCTTCGATCGCAGGCTGGAAGGCCATCAACGAATCCGACATGGTTTTGAT
GCCCGATCCGGAAACGGCTCATATCGACCCGTTCTTCGCCCAGTCCACGCTTGTCATTCTCTGCGATATC
CTTGAGCCGCTTTCCGGCGAAAGCTACAGCCGTGATCCGCGTACGACTGCCAAGAAGGCCGAAGCCTATC
TGAAATCGCTCGGCATTGGCGATACGGTCTATGTCGGCCCGGAAGCCGAATTCTTCGTCTTCGACGATGT
GAAGTTCAAGGCCGATCCGTTCAATACGGGCTTCAAGCTCGATAGCGCCGAATTGCCATCCAACGACGAC
ACCGATTATGAAACCGGCAATCTCGGCCATCGTCCGCGCGTCAAGGGCGGCTATTTCCCCGTTCCGCCAA
TCGACAGCTTGCAGGACATGCGTTCCGAAATGCTGACCGTGCTCTCGGAAATGGGTGTGACGGTTGAAAA
GCACCACCATGAAGTCGCTTCCGCGCAGCACGAACTGGGCACGAAATTCGACACGCTGGTGCGCAACGCC
GACAAGATGCAGATTCAGAAATATGTCGTGCATCAGGTTGCCAATGCCTATGGCAAAACGGCAACCTTCA
TGCCGAAGCCGGTCTTTGGCGACAATGGCTCCGGCATGCATGTTCACTTCTCGATCTGGAAAGACGGCAA
GCCGACCTTCGCAGGCAATGAATATGCTGGTCTGTCGGAAAACTGCCTCTACTTCATTGGCGGCGTCATC
AAGCACGCAAAAGCTGTGAATGCCTTCACCAACCCGTCCACCAACTCCTACAAGCGTCTGGTGCCGGGCT
ATGAAGCGCCTGTTCTGCTGGCCTATTCCGCACGCAACCGTTCGGCTTCCTGCCGCATTCCATTCGGCTC
CTCGCCGAAATCGAAGCGTCTCGAATTCCGCTTCCCGGATCCGTCCGCCAACCCTTATCTCTGCTTCTCG
GCCCTTCTGATGGCGGGCCTTGACGGCATCAAGAACAAGATCCATCCGGGCCAGGCCATGGACAAGGATC
TCTACGACCTGCCGCCGAAGGAACTGAAGCAGATTCCGACCGTCTGCGGCTCCCTGCGTGAAGCTCTACA
GTCGCTCGACAAGGATCGTGAATTCCTCAAGGCTGGCGGCGTGTTCTCCGACGACCAGATCGACAGCTTC
ATCGAGCTGAAAATGGCTGAAGTGATGCGTTTTGAAATGACGCCGCACCCGGTCGAGTTCGATATGTATT
ACTCGGTATA
Protein Sequence 
>gi|17987262|ref|NP_539896.1| glutamine synthetase [Brucella melitensis bv. 1 str. 16M] MTTANDILKQIKDNDVKFVDLRFTDPKGKLHHVTMDIGLVDEDMFVDGVMFDGSSIAGWKAINESDMVLMPDPETAHIDPFFAQSTLVILCDILEPLSGESYSRDPRTTAKKAEAYLKSLGIGDTVYVGPEAEFFVFDDVKFKADPFNTGFKLDSAELPSNDDTDYETGNLGHRPRVKGGYFPVPPIDSLQDMRSEMLTVLSEMGVTVEKHHHEVASAQHELGTKFDTLVRNADKMQIQKYVVHQVANAYGKTATFMPKPVFGDNGSGMHVHFSIWKDGKPTFAGNEYAGLSENCLYFIGGVIKHAKAVNAFTNPSTNSYKRLVPGYEAPVLLAYSARNRSASCRIPFGSSPKSKRLEFRFPDPSANPYLCFSALLMAGLDGIKNKIHPGQAMDKDLYDLPPKELKQIPTVCGSLREALQSLDKDREFLKAGGVFSDDQIDSFIELKMAEVMRFEMTPHPVEFDMYYSV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis glnA gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0174E, under E: Amino acid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].