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uppS from Brucella melitensis bv. 1 str. 16M

Victor ID 1246
Gene Name uppS from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1196538
NCBI Protein GI 17987110
Locus Tag BMEI0827
Protein Accession NP_539744.1
Other Database IDs UniProtKB-ID: D0B993_BRUME
UniRef100: UniRef100_Q57CY1
UniRef90: UniRef90_Q57CY1
UniRef50: UniRef50_Q8G0D9
UniParc: UPI0000057E25
EMBL: GG703780
EMBL-CDS: EEW86749.1
RefSeq_NT: NC_003317.1
OMA: RVRWAGR
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 849740
Gene Ending Position 850504
Gene Strand (Orientation) +
Protein Name UNDECAPRENYL PYROPHOSPHATE SYNTHETASE
DNA Sequence 
>gi|17986284:849740-850504 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
CATGTCCGATCCGCGCCACATAGCCATTATCATGGATGGCAACGGCCGTTGGGCTAAGGCGCGCGGCTTG
CCGCGCAGCGCGGGGCACCGCGCGGGCGTGGAGGCCTTGCGGGAGATCGTGCGGGCCGCGGGAGATCGCG
GCCTCGGCTATCTTACGCTTTTTGCTTTCTCTTCCGAAAACTGGACCCGTCCGAGCGGCGAGGTCAGCGA
TCTTCTGGGGCTTTTGAAGCTCTTCATCCGGCGCGATCTGGCAGAGCTTCACCGCAACAATGTGCGTGTC
AATATTATCGGCGAGCGGGCGGAGCTCGCAGCCAATATCCGTGCACTGTTGAACGAAGCGGAATCGCTTA
CCCATCGCAATACCGGCCTCAATCTCGTGATTGCCTTCAATTACGGTTCACGCGATGAGATTGTTCGTGC
GGTCAGAAGCCTTGCGCGCGATGTCGCCGCCGGGCTTCTTGATCCATCCTCGATCTCGGCGGAGCTTGTT
TCCGCTAATCTTGATACGGCGGGAATACCTGATCCCGACCTCATCATCCGCACCAGTGGCGAGATGCGGC
TTTCCAACTTTCTTCTCTGGCAGGCTGCCTATTCCGAGTTTCTCTTTCTGCCATGTCACTGGCCGGATTT
CCGGCCGGCCGACCTTGATGCGGCCTATGAAACGTTCCGGCAGCGCGAGCGTCGTTTTGGCGGTGTGGAG
CCGCGCGCCAGTGCGGATGCCGAAGAAGAAATATTATGCCCTTCGACCAAGGGAGCGGCAGTCTA
Protein Sequence 
>gi|17987110|ref|NP_539744.1| undecaprenyl pyrophosphate synthase [Brucella melitensis bv. 1 str. 16M] MSDPRHIAIIMDGNGRWAKARGLPRSAGHRAGVEALREIVRAAGDRGLGYLTLFAFSSENWTRPSGEVSDLLGLLKLFIRRDLAELHRNNVRVNIIGERAELAANIRALLNEAESLTHRNTGLNLVIAFNYGSRDEIVRAVRSLARDVAAGLLDPSSISAELVSANLDTAGIPDPDLIIRTSGEMRLSNFLLWQAAYSEFLFLPCHWPDFRPADLDAAYETFRQRERRFGGVEPRASADAEEEILCPSTKGAAV
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide (By similarity)(UniProt: Q8G0D9).

CATALYTIC ACTIVITY: Di-trans,poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans,poly-cis-undecaprenyl diphosphate(UniProt: Q8G0D9).

COFACTOR: Magnesium (By similarity)(UniProt: Q8G0D9).

SUBUNIT: Homodimer (By similarity)(UniProt: Q8G0D9).

SIMILARITY: Belongs to the UPP synthetase family(UniProt: Q8G0D9).

MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis uppS gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0020I, under I: Lipid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].