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bicA

Victor ID 1234
Gene Name bicA
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1196316
NCBI Protein GI 17986888
Locus Tag BMEI0605
Genbank Accession AE008917
Protein Accession NP_539522
Other Database IDs UniProtKB-ID: D0B8M5_BRUME
UniRef100: UniRef100_D0B8M5
UniRef90: UniRef90_B2S6M5
UniRef50: UniRef50_B2S6M5
UniParc: UPI0000057D47
EMBL: GG703780
EMBL-CDS: EEW86531.1
RefSeq_NT: NC_003317.1
OMA: AVQMSLL
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 632193
Gene Ending Position 633464
Gene Strand (Orientation) +
Protein Name bicyclomycin resistance protein
Protein pI 10.71
Protein Weight 42665.55
Protein Length 423
DNA Sequence 
>gi|17986284:632193-633464 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
CATGGCTTCCAGTCTTGTGCGCAATGCCATTGTTCTTGGCCTTCTTTCGGCCATCGGTCCTTTTGCGATT
GATATGTATCTACCGGCCCTGCCGACCATTGCCACCGATCTGCGGGCGGAAACCGGCGCGGTGCAGATGA
GCCTGCTCGCCTTCTTTCTGGCACTGGCGCTGGCGCAGCTTTTCTGCGGGCCCCTGTCCGATATGGTCGG
GCGTAAACTGCCGCTTTATGGCGGGCTGGTGCTCTTCGCCATAGGCAGCATCGGTTCGGCGCTTGCGGCC
AATATCGACGTGCTGGTGCTGTTCCGTTTCATCCAGGGATTGGGGGCTGCGGCAGGCATGGTGATACCGC
GCGCCATCGTGCGCGATCTTCATACGGGTGTCGAGGCCGCGCGCCTTATGTCGCTTTTGATGCTGGTCTT
TTCGATTTCGCCGATTCTGGCCCCGCTGACTGGCTCCATCATCATAAGCTTTTTCGGCTGGCGCGGGGTT
TTCTGGGCCGTGTTGCTTGCCGCCGGCATCGGCATCATACTGGTTGCGACCGCGCAGAAGGAAACGCGCA
GCGTCGAGGCGCGGCTTGAGAGCAATATCAGCAGCGCATTGCGCGGTTACGGGCGGCTGTTGAAGGACCG
TCATTTCCTCGGCCTCGTCTTCGTGGGCGGTTTCGGTCTTGCGTCCTTGTTCGTTTATCTGGCGAATTCC
GCCTTCGTGCTGATCGACCATTATGGCCTGACACCGATACAATATGCCGTGGCATTTTCCGCCAATGCCG
TGTCGTTCTTCGGCGTTTCGCAGCTCAACGGCTGGCTTGGCGCGCGTTTCGGCCTTGGCCGGGTGATGCG
CTTTGCTGCTTGCGGCTTTGCCGCAGCAATGCTTGCCATGTTCGCGGCGGCGCTGATGGGGCATCAATCA
ACTCTGGTTGGTCGCAAGCTTCCTCTTTGTCGGTTACGGCTTCCTTGGGCTGGTTATTCCAGCTACGGCG
GTGCTGGCGCTCGAAGAACACGGCGAGATTGCCGGAACGGCATCTGCATTGATGGGCACGCTTCACTTCG
TCATTGGTGGCGTGGCGATTGGTATTGTCGGAGCCTATTCCGATGGCACGGCGCTGCCGATGATTGGCGG
CATCACCGGCTGTGCGCTGGCGGCGTTCGTGCTGGCGCAGATCGTCCTTGCCCGCAAGTCGAGAAAGCGC
GGCAGAGCAACGGCGGCAGCCTGATTTTCAGGGGAAATGAAGTGGAGGCTTCTGTTGCCAGGTGCCTCCG
AACCCCGCCTTA
Protein Sequence 
>gi|17986888|ref|NP_539522.1| bicyclomycin resistance protein [Brucella melitensis bv. 1 str. 16M]
MASSLVRNAIVLGLLSAIGPFAIDMYLPALPTIATDLRAETGAVQMSLLAFFLALALAQLFCGPLSDMVG
RKLPLYGGLVLFAIGSIGSALAANIDVLVLFRFIQGLGAAAGMVIPRAIVRDLHTGVEAARLMSLLMLVF
SISPILAPLTGSIIISFFGWRGVFWAVLLAAGIGIILVATAQKETRSVEARLESNISSALRGYGRLLKDR
HFLGLVFVGGFGLASLFVYLANSAFVLIDHYGLTPIQYAVAFSANAVSFFGVSQLNGWLGARFGLGRVMR
FAACGFAAAMLAMFAAALMGHQSTLVGRKLPLCRLRLPWAGYSSYGGAGARRTRRDCRNGICIDGHASLR
HWWRGDWYCRSLFRWHGAADDWRHHRLCAGGVRAGADRPCPQVEKARQSNGGSLIFRGNEVEASVARCLR
TPP
Molecule Role Virulence factor
Molecule Role Annotation FUNCTIONAL GROUP: "Classical virulence factors", Secretion of transport system, Transpter (Delrue et al., 2004).

FUNCTION: Macrolide efflux (Delrue et al., 2004).

MUTATION: Attenuated in Macrophages (Delrue et al., 2004).
COG COG2814G, under G: Carbohydrate transport and metabolism
References
Delrue et al., 2004: Delrue RM, Lestrate P, Tibor A, Letesson JJ, De Bolle X. Brucella pathogenesis, genes identified from random large-scale screens. FEMS microbiology letters. 2004; 231(1); 1-12. [PubMed: 14979322].