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carAB

Victor ID 1232
Gene Name carAB
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1196237
NCBI Protein GI 161511156
Locus Tag BMEI0526
Genbank Accession NZ_GG703780
Protein Accession NP_539443
Other Database IDs UniProtKB-ID: D0B9U7_BRUME
UniRef100: UniRef100_B2S6U9
UniRef90: UniRef90_B2S6U9
UniRef50: UniRef50_B2S6U9
UniParc: UPI0000126F33
EMBL: GG703780
EMBL-CDS: EEW86453.1
RefSeq_NT: NC_003317.1
OMA: FTYPELG
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 547377
Gene Ending Position 548600
Gene Strand (Orientation) -
Protein Name carbamoyl phosphate synthase small subunit
Protein pI 5.82
Protein Weight 40361.19
Protein Length 407
Protein Note catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
DNA Sequence 
>gi|17986284:547377-548600 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
TTCAGGCAGCCTGTTCGCGCTCCGGCAGAGGAGCCTGGCCTTTCCTCTCGCGGATGAGATTGATGAACCG
GCGGAACAGATAGTGCGAATCCTGCGGGCCGGGGGAGGCTTCCGGGTGATGCTGCACGGAGAAGACTGGC
TTGCCGACGACACGCAGGCCGCAATTGGTGCCGTCGAAGAGCGACACATGGGTTTCCTCGACATTTTCCG
GCAGCGAGTCCGAATCAACTGCGAAACCGTGATTCATCGAGACGATTTCCACCTTGCCGGTCGTATAATC
CTTCACCGGGTGGTTTGCACCGTGATGGCCCTGATGCATCTTTTCCGTGCGTCCGCCGAGCGCCAGCGCC
AGCATCTGGTGGCCGAGGCAGATGCCGAAAAGGGGAATGCCGGTTTCCACCAGCTTGCCGATGGTCGGCA
CGGCATATTCGCCCGTTGCCGCCGGATCGCCGGGACCATTGGACAGGAAAACGCCATCGGGATTATGCGC
CAGAACGTCTTCGGCTGTTGCCGTGGCCGGTAAAACCGTGACCTTTGCGCCAAGCCCGGTCAGAAGGCGC
AGAATATTGCGCTTCACACCGAAATCGAGAGCGACGACGTGATATTGCGGTGCGTCCTGTTCGCCATAGC
CGTCCTGGAGTGTCCATGGCAGTTCCTTCCAGACGAGGCTCTGGCCGATGGTGACATCCTTGGCGAGATC
GAGATTTTCAAGGCCGCACCAGTTGGCGGCGCGCGCTTTCAGGGCGTCGAGATCGAAATTTCCGTTCGGG
TCATGCGCGATAACGGCGTTTTGCGCGCCACGCTCGCGGATGAGGGCGGTGAGGGCGCGGGTGTCGATGC
CGGCAAGCGCAATGATTCCGCGATGCTTGAGCCAGCTATCGAGGTCTTTTGCGGCACGGAAATTCGAGGG
TGCGGTGATGTCTGCCTTGAAGATCGCGCCGACTGCGCCGTGGCGGTTGGCGGGTGTCAGATCTTCGATA
TCTTCGGCATTGGCGCCGACATTGCCGATATGTGGGAAAGTGAAGGTGACGATCTGTCCGGCATAGGACG
GGTCGGTCAGTATTTCCTCATAGCCGGTGAGAGCGGTGTTGAAGACGACTTCGGCCTCAACCGCGCCGGT
CGCGCCCAGGCCCTTGCCTTCGATCACGGTTCCATCGGCGAGGACGAGAACGGCGGTTCGCTTCTGAACG
GTCCAGGGTGCTGTTTTCGGGGTCGTTTCAGTCA
Protein Sequence 
>gi|161511156|ref|NP_539443.2| carbamoyl phosphate synthase small subunit [Brucella melitensis bv. 1 str. 16M]
MTETTPKTAPWTVQKRTAVLVLADGTVIEGKGLGATGAVEAEVVFNTALTGYEEILTDPSYAGQIVTFTF
PHIGNVGANAEDIEDLTPANRHGAVGAIFKADITAPSNFRAAKDLDSWLKHRGIIALAGIDTRALTALIR
ERGAQNAVIAHDPNGNFDLDALKARAANWCGLENLDLAKDVTIGQSLVWKELPWTLQDGYGEQDAPQYHV
VALDFGVKRNILRLLTGLGAKVTVLPATATAEDVLAHNPDGVFLSNGPGDPAATGEYAVPTIGKLVETGI
PLFGICLGHQMLALALGGRTEKMHQGHHGANHPVKDYTTGKVEIVSMNHGFAVDSDSLPENVEETHVSLF
DGTNCGLRVVGKPVFSVQHHPEASPGPQDSHYLFRRFINLIRERKGQAPLPEREQAA
Molecule Role Virulence factor
Molecule Role Annotation FUNCTIONAL GROUP: a.a. metabolism, Synthesis (Delrue et al., 2004).

FUNCTION: Clut. and pyr. Syntheis (Delrue et al., 2004).

MUTATION: Attenuated in Macrophages (Delrue et al., 2004).
References
Delrue et al., 2004: Delrue RM, Lestrate P, Tibor A, Letesson JJ, De Bolle X. Brucella pathogenesis, genes identified from random large-scale screens. FEMS microbiology letters. 2004; 231(1); 1-12. [PubMed: 14979322].