Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

macA from Brucella melitensis bv. 1 str. 16M

Victor ID 1220
Gene Name macA from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1196070
NCBI Protein GI 17986642
Locus Tag BMEI0359
Protein Accession NP_539276.1
Other Database IDs UniProtKB-ID: D0BAB4_BRUME
UniRef100: UniRef100_D0BAB4
UniRef90: UniRef90_D0BAB4
UniRef50: UniRef50_C3ME72
UniParc: UPI0000057C52
EMBL: GG703781
EMBL-CDS: EEW86290.1
RefSeq_NT: NC_003317.1
OMA: ARIDMIQ
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 370348
Gene Ending Position 371574
Gene Strand (Orientation) +
Protein Name periplasmic component of efflux system
DNA Sequence 
>gi|17986284:370348-371574 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
GGTGCTTAAATCTAGTGATTCTTCTCAATTAGGCCAGCAACCGGCATCGGCCCGCAAACGCGCCAAAGGA
AAGCGCCGCTGGTGGCTCTGGCTTTCAGCCGCCGCCATCATCATCGGCGCGGGCTGGTACTTCTACGGCT
CTTATAAGGCTGACGGCGAGAAGAGCAGCTATCTTGCGGAGACTGTCACCCGTGGTGACATCGAAAACGC
CATCACCGCCGTCGGCACGCTGAGCGCATTGCGCAGCGTCAACGTTGGCGCGCAGGTTTCCGGCCAGTTG
AAAAGCGTGAAGGTGGAAGTGGGCGATCACGTCAAACAAGGCCAGCTCATTGCCGAAATCGATCCTTCAC
CGTTTGAAAAGAAGGTGGAGATCGCAGGCGCCCAGCTCGACAATCTGAAAGCCCAATTGCTCAGCAAGGA
CGCACAACTGACGCTGAAGAAGCTCAATGCCGCGCGGCAGAAATCCCTCCTCGCCACACGCGGCGTCTCG
CAGGCGACCGTCGATCAGGCCAATGCCGATCTTTTAATGGCCGAAGCGGAGGTAAAGGCGCTCAACGCAC
AAATCCGCCAGCAGGAAGCACAGCTTGCAAGCGACAAGGTCGATCTCGGCTACACCTCCATCTATAGCCC
CATGGAAGGCACGGTCGTTGACGAGGCTGCCAAGGAAGGCGAAACGCTCAATGCCGTGCAGAGCGCACCC
ACCATTGTCACGGTCGCAGACCTGAAAGTAATGACGGTGGAAGCACAGGTTTCGGAAGCCGACATTTCCA
AGCTGAAGCCGGGAATGCCTGTCTATTTCACGCTGCTTGGCCAGCCCGACAAGCGTTTTACCGGCACGCT
TCGCCAGATCAAGCCGACACCTGCGACAGATAACAATGTCGTTCTCTATTATGCCCTGTTCGACGTGCCG
AACCCGACTGGCGAATTGATGATCGACATGAGTGCGCAGGTCTATTTCGTTCTGGGTGAGGCGAAGGACG
TGCTCGTTGTCCCCACGGCAGCCCTTACTGACAAGCAGAAAGGCGGCAAGCCGCAAGTCACCGTCAAGGT
GGCCGACGAGAGCGGTACCCTCGTGGAGCGCCCGGTCAAGGTCGGCGTGCGCAACCGCGTGCTGGCCGAA
ATCCAGAGCGGGCTTGAGGAAGGCGATCGCGTGGTTGTCACCGCCGCCACCGGCAATGGCGCAGCGGGAG
GCGAACGCGGACGCAGACCCAGTATGCGCTTCTTCTG
Protein Sequence 
>gi|17986642|ref|NP_539276.1| periplasmic protein of efflux system [Brucella melitensis bv. 1 str. 16M] MLKSSDSSQLGQQPASARKRAKGKRRWWLWLSAAAIIIGAGWYFYGSYKADGEKSSYLAETVTRGDIENAITAVGTLSALRSVNVGAQVSGQLKSVKVEVGDHVKQGQLIAEIDPSPFEKKVEIAGAQLDNLKAQLLSKDAQLTLKKLNAARQKSLLATRGVSQATVDQANADLLMAEAEVKALNAQIRQQEAQLASDKVDLGYTSIYSPMEGTVVDEAAKEGETLNAVQSAPTIVTVADLKVMTVEAQVSEADISKLKPGMPVYFTLLGQPDKRFTGTLRQIKPTPATDNNVVLYYALFDVPNPTGELMIDMSAQVYFVLGEAKDVLVVPTAALTDKQKGGKPQVTVKVADESGTLVERPVKVGVRNRVLAEIQSGLEEGDRVVVTAATGNGAAGGERGRRPSMRFF
Molecule Role Virulence factor
Molecule Role Annotation FUNCTIONAL GROUP: "Classical virulence factors", Secretion of transport system, Transpter (Delrue et al., 2004).

FUNCTION: Macrolide efflux (Delrue et al., 2004).

MUTATION: Attenuated in Mice, Macrophages, HeLa (Delrue et al., 2004).
COG COG0845M, under M: Cell wall/membrane/envelope biogenesis
References
Delrue et al., 2004: Delrue RM, Lestrate P, Tibor A, Letesson JJ, De Bolle X. Brucella pathogenesis, genes identified from random large-scale screens. FEMS microbiology letters. 2004; 231(1); 1-12. [PubMed: 14979322].