Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

pyc from Brucella melitensis bv. 1 str. 16M

Victor ID 1212
Gene Name pyc from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1195978
NCBI Protein GI 17986550
Locus Tag BMEI0266
Protein Accession NP_539184.1
Other Database IDs UniProtKB-ID: D0BA19_BRUME
UniRef100: UniRef100_D1EZS9
UniRef90: UniRef90_A6WXY5
UniRef50: UniRef50_A6UE85
UniParc: UPI0000057BF7
EMBL: GG703781
EMBL-CDS: EEW86195.1
RefSeq_NT: NC_003317.1
OMA: DIVQSQI
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 276057
Gene Ending Position 279533
Gene Strand (Orientation) +
Protein Name pyruvate carboxylase
DNA Sequence 
>gi|17986284:276057-279533 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
CTTGTCTTTCGCTCCAAAGCCTATCTCGAAAATTCTGGTCGCCAACCGATCTGAAATCGCAATTCGCGTA
TTCCGCGCCGCCAATGAGCTGGGGCTCAAAACGGTGACCATATGGGCTGAGGAAGACAAGCTTTCTCTGC
ATCGCTTCAAGGCGGACGAAAGCTATCAGGTCGGTCGCGGACCGCACCTGGATCGCGATCTTGGCCCCAT
TGAAAGCTATCTTTCCATTGACGAAATCATCCGCGTTGCCAAGCTTTCGGGCGCCGATGCGATCCATCCA
GGTTACGGTCTCCTGTCGGAAAGCCCGGAATTTGCCGAAGCCTGCGCGGAAAACGGTATCGTCTTCATCG
GGCCGAAGCCGGAAACCATGCGCCGCCTCGGCAACAAGGTCGCCGCGCGCAATCTCGCTATCGAGATTGG
CGTGCCGGTGGTGCCTGCCACCGATCCGCTGCCGGATGATATGGATGAGGTGAAGAAGCTTGCCGCCCAG
ATCGGCTATCCGCTGATGCTGAAAGCAAGCTGGGGCGGCGGCGGCCGCGGTATGCGCGCCATCCGGGCTG
AAGCCGATCTTGCCCGCGAGGTGATGGAAGCCAAGCGCGAGGCCAAGGCGGCCTTTGGCAAGGATGAAGT
TTATCTCGAAAAGCTGGTGGAGCGTGCCCGCCATGTCGAAGTGCAGATATTGGGCGATACGTACGGCAAT
GCGGTCCATCTTTTTGAGCGTGACTGCTCCATCCAGCGCCGTAACCAGAAGGTCGTGGAGCGCGCGCCTG
CACCCTATCTCAACGATGCGCAGCGCCGCGAGCTGGCCGATTATGGCCTGAAGATCGCGCATGCCACCGA
TTATATCGGTGCTGGCACGGTTGAGTTCCTCATGGATGCCGATACCGGCAAGTTCTATTTCATCGAGGTC
AATCCACGCATTCAGGTGGAGCATACGGTCACGGAAGAAGTGACCGGCATCGATATCGTCAAGGCGCAGA
TCCATATTCTGGAAGGCTTTGCCATCGGCACGCCGGAATCGGGCGTGCCGCGCCAGGAGGATATCCGCCT
CAATGGCCACGCGCTGCAATGCCGCATCACAACGGAAGACCCGGAACAGAATTTCATCCCCGATTACGGG
CGCATTCAGGCCTATCGTTCGGCGGCGGGCTTCGGCATCCGTCTCGATGGCGGCACGGCCTATTCGGGCG
CATTCATCACCCGTTATTACGACCCGCTTCTGGTAAAGGTGACGGCATCCGGCGCGACGCCGCTTGAAGC
CATTCACCGCATGGACCGCGCCTTGCGCGAGTTCCGCATTCGCGGCGTGGCAACGAACCTCACCTTCCTC
GAAGCGATCATCAATCATCCGAAATTCCTGTCGAACGATTATACGACCCGTTTCATCGATACGACGCCGG
AATTGTTCGAGCAGATGAAGCGGCAGGATCGCGCCACCAAGCTTTTGACCTATATTGCCGATGTGACCGT
CAACGGCCATCCCGAAACCAAGGGCCGCGCGAAACCCGCCAGGGATGCTGCCAAGCCGCGCGTGCCGTGG
TTTGGCGACAAGCTGGTCGCTGACGGCACCAAACAGCTTCTGGACCAGCTTGGGCCGAAGAAGTTTGCCG
AATGGATGCGCAATGAAAAGCGCGCGCTGATTACTGATACCACCATGCGCGATGGCCACCAGTCATTGCT
TGCCACGCGCGTGCGCACCTATGATATTGCGCGGATCGCCAATGCTTACGCGCAGGCGCTGCCAAACCTG
TTCTCGCTGGAATGCTGGGGCGGGGCTACTTTCGACGTCTCCATGCGCTTCCTGACCGAAGACCCGTGGG
AGCGTCTGGCACTGGTGCGCGAAGGCGCGCCCAACCTCCTGTTGCAGATGCTTCTGCGCGGTGCGAACGG
GGTTGGCTACAAATCCTATCCGGACAATGTGGTGAAATATTTCGTGCGCGAGGCAGCGCGCGCGGGCATT
GACCTGTTCCGCGTTTTCGACAGCCTCAACTGGGTTGAGAACATGCGCGTGTCGATGGATGCGGTGCTGG
AGGAAAACAAGCTCTGTGAAGCGGCGATCTGCTATACGGGCGATATTTTGAACCCGGATCGCGCCAAATA
CGACCTTAATTATTACGTCAATCTGGCGAAGGAAGTGGAAAAGGCTGGCGCGCATATTATTGCGGTCAAG
GATATGGCGGGCTTGCTGAAGCCTGCCGCCGCGCGCGTGCTGTTCAAGGCGCTGCGCGAGGAAACCGATC
TGCCGATCCATTTCCACACACATGATACGTCGGGCATTTCGGCGGCGACCGTGCTTGCTGCAATCGATGC
GGGCGTGGATGTCGTGGATGCAGCGATGGACGCACTTTCGGGCAATACATCGCAGCCCTGCCTCGGTTCC
ATCGTTGAAGCGCTGCATGGTTCCGAGCGTGATTCGGGGCTCGACCCGGATTTGATCCGCCGTATTTCCT
TTTATTGGGAAGCGGTGCGCCATCAATATGCAGCTTTTGAAAGCGACCTCAAGGGACCGGCTTCGGAAGT
CTATCTTCACGAAATGCCGGGTGGCCAGTTCACCAATCTGAAGGAACAGGCGCGCTCGCTGGGGCTTGAA
ACGCGCTGGCATGAAGTGGCGCAGGCCTATGCCGATGTGAACCGCATGTTCGGCGATATCGTCAAGGTCA
CGCCATCCTCCAAGGTGGTGGGCGACATGGCGCTGATGATGGTTGCCCAAGACCTCACCGTTGCCGATGT
CGAGAACCCTGCCAAGGATATTGCCTTCCCGGATTCGGTGGTTTCCATGATGCGTGGCGATCTCGGCCAG
CCGCCATCCGGCTGGCCGGAAGCCTTGCAGAAAAAGGTTCTGAAAGATGAAAAGCCTTTCACCGTGCGCC
CCGGCTCGCTTCTGCCTGCCGCCGATCTCGATGCGGAACGCAAGAGCTTTGAGGACAGTGTCGGCCGCAA
GCTTTCCGATCAGGAATTTGCTTCGGCGCTGATGTATCCGAAGGTCTTCACCGATTATGCTACGGCGCAT
GAAACCTATGGTCCGACGAGCGTGCTGCCGACGCCGGTTTATTTCTACGGCCTCAAGCCGGAAGAAGAAG
TTTTTGTCGATCTGGAGCGTGGCAAGACGCTGGTGATCGTCAATCAGGCTATGAGCGAGACCGACGAGAA
GGGCATGGTGACGGTGTTCTTCGAGCTGAACGGCCAGCCGCGCCGCATCAAGGTGCCAAACCGTGCCAAG
GGTGCTTCCGGTGGTGTCCGCCGCAAGGTGGAGGCGGGCAATGACAAACAGGTCGGTGCGCCAATGCCGG
GCGTTATCTCCACCGTTGCGGTTGTGGCAGGCCAGAAGGTTACGCAGGGCGACGTGCTTCTATCCATCGA
GGCGATGAAGATGGAAACCGCCATCCATGCCGAACGCGATGGCACTATCGCGGAAGTGCTGGTCCGCCCC
GGCGAGCAGATCGACGCGAAGGATTTGCTCATCGTTTACGCCGAGTA
Protein Sequence 
>gi|17986550|ref|NP_539184.1| pyruvate carboxylase [Brucella melitensis bv. 1 str. 16M] MSFAPKPISKILVANRSEIAIRVFRAANELGLKTVTIWAEEDKLSLHRFKADESYQVGRGPHLDRDLGPIESYLSIDEIIRVAKLSGADAIHPGYGLLSESPEFAEACAENGIVFIGPKPETMRRLGNKVAARNLAIEIGVPVVPATDPLPDDMDEVKKLAAQIGYPLMLKASWGGGGRGMRAIRAEADLAREVMEAKREAKAAFGKDEVYLEKLVERARHVEVQILGDTYGNAVHLFERDCSIQRRNQKVVERAPAPYLNDAQRRELADYGLKIAHATDYIGAGTVEFLMDADTGKFYFIEVNPRIQVEHTVTEEVTGIDIVKAQIHILEGFAIGTPESGVPRQEDIRLNGHALQCRITTEDPEQNFIPDYGRIQAYRSAAGFGIRLDGGTAYSGAFITRYYDPLLVKVTASGATPLEAIHRMDRALREFRIRGVATNLTFLEAIINHPKFLSNDYTTRFIDTTPELFEQMKRQDRATKLLTYIADVTVNGHPETKGRAKPARDAAKPRVPWFGDKLVADGTKQLLDQLGPKKFAEWMRNEKRALITDTTMRDGHQSLLATRVRTYDIARIANAYAQALPNLFSLECWGGATFDVSMRFLTEDPWERLALVREGAPNLLLQMLLRGANGVGYKSYPDNVVKYFVREAARAGIDLFRVFDSLNWVENMRVSMDAVLEENKLCEAAICYTGDILNPDRAKYDLNYYVNLAKEVEKAGAHIIAVKDMAGLLKPAAARVLFKALREETDLPIHFHTHDTSGISAATVLAAIDAGVDVVDAAMDALSGNTSQPCLGSIVEALHGSERDSGLDPDLIRRISFYWEAVRHQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHEVAQAYADVNRMFGDIVKVTPSSKVVGDMALMMVAQDLTVADVENPAKDIAFPDSVVSMMRGDLGQPPSGWPEALQKKVLKDEKPFTVRPGSLLPAADLDAERKSFEDSVGRKLSDQEFASALMYPKVFTDYATAHETYGPTSVLPTPVYFYGLKPEEEVFVDLERGKTLVIVNQAMSETDEKGMVTVFFELNGQPRRIKVPNRAKGASGGVRRKVEAGNDKQVGAPMPGVISTVAVVAGQKVTQGDVLLSIEAMKMETAIHAERDGTIAEVLVRPGEQIDAKDLLIVYAE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pyc is one B. suis gene identified by signature-tagged mutagenesis. It is essential for survival and mulitplication in macrophages (Foulongne et al., 2000).
COG COG1038C, under C: Energy production and conversion
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].